Murcko scaffold
Ring system with 5 rings and 30 atoms
41 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 30
- Chemicals
- 41
- With full pages
- 3
Scaffold SMILES
O=C1N=C(N2CCCCC2)SC1=Cc1cn(-c2ccccc2)nc1-c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 41 of 41 chemicals
![1-[(5Z)-5-{[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide chemical structure, C26H25N5O3S, CAS 1009187-98-7](/s/LRGAGQXSEIRUFN-JCMHNJIXSA-N.svg)
1-[(5Z)-5-{[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
CAS 1009187-98-7C26H25N5O3S
![1-[(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide chemical structure, C27H27N5O3S, CAS 1008883-35-9](/s/ATQCNMHMDAQGAW-KQWNVCNZSA-N.svg)
1-[(5Z)-5-{[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
CAS 1008883-35-9C27H27N5O3S
![1-[(5Z)-5-{[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide chemical structure, C29H31N5O3S, CAS 890014-96-7](/s/VIDACBZRFJQQPE-BWAHOGKJSA-N.svg)
1-[(5Z)-5-{[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
CAS 890014-96-7C29H31N5O3S
![5-{(Z)-1-[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one chemical structure, C26H26N4O2S, CAS 1009189-36-9](/s/QHZICGSPAJZEJZ-QJOMJCCJSA-N.svg)
5-{(Z)-1-[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one
CAS 1009189-36-9C26H26N4O2S
![5-((Z)-1-{1-Phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-2-piperidino-1,3-thiazol-4-one chemical structure, C27H28N4OS2, CAS 1009433-80-0](/s/ILRYYSRJWVBXPL-MOHJPFBDSA-N.svg)
5-((Z)-1-{1-Phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-2-piperidino-1,3-thiazol-4-one
CAS 1009433-80-0C27H28N4OS2
![(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(piperidin-1-yl)-1,3-thiazol-4(5H)-one chemical structure, C28H30N4OS2, CAS 1009434-55-2](/s/BSSXDAQNSOKDNL-PLRJNAJWSA-N.svg)
(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(piperidin-1-yl)-1,3-thiazol-4(5H)-one
CAS 1009434-55-2C28H30N4OS2
![(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one chemical structure, C29H32N4OS2, CAS 1008879-43-3](/s/NSDVXTDBEKNQMJ-XHPQRKPJSA-N.svg)
(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one
CAS 1008879-43-3C29H32N4OS2
![(5Z)-2-(4-Methylpiperidin-1-yl)-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-1,3-thiazol-4(5H)-one chemical structure, C28H30N4OS2, CAS 1009186-01-9](/s/BWLMRWTZNKVYID-BWAHOGKJSA-N.svg)
(5Z)-2-(4-Methylpiperidin-1-yl)-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-1,3-thiazol-4(5H)-one
CAS 1009186-01-9C28H30N4OS2
![1-[(5Z)-4-Oxo-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide chemical structure, C28H29N5O2S2, CAS 1009434-82-5](/s/FOWMMGUQOQBYTQ-ULJHMMPZSA-N.svg)
1-[(5Z)-4-Oxo-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
CAS 1009434-82-5C28H29N5O2S2
![5-((Z)-1-{3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-piperidino-1,3-thiazol-4-one chemical structure, C26H26N4OS2, CAS 1009435-12-4](/s/LRYVVVYXQBKHIZ-QJOMJCCJSA-N.svg)
5-((Z)-1-{3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-piperidino-1,3-thiazol-4-one
CAS 1009435-12-4C26H26N4OS2
![5-((Z)-1-{3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(4-methylpiperidino)-1,3-thiazol-4-one chemical structure, C27H28N4OS2, CAS 1009435-28-2](/s/MYGDEKYXSUPYEK-ULJHMMPZSA-N.svg)
5-((Z)-1-{3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(4-methylpiperidino)-1,3-thiazol-4-one
CAS 1009435-28-2C27H28N4OS2
![1-[(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide chemical structure, C29H31N5O2S2, CAS 1009186-82-6](/s/HDQTVQBJDFDVTE-BWAHOGKJSA-N.svg)
1-[(5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
CAS 1009186-82-6C29H31N5O2S2
![5-{(Z)-1-[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one chemical structure, C26H25ClN4O2S, CAS 1009435-69-1](/s/ATDFRRPWDUUNJS-KQWNVCNZSA-N.svg)
5-{(Z)-1-[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one
CAS 1009435-69-1C26H25ClN4O2S
![(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(piperidin-1-yl)-1,3-thiazol-4(5H)-one chemical structure, C27H27ClN4O2S, CAS 1009187-23-8](/s/LMJRJYLKMCDIGC-ULJHMMPZSA-N.svg)
(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(piperidin-1-yl)-1,3-thiazol-4(5H)-one
CAS 1009187-23-8C27H27ClN4O2S
![(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one chemical structure, C28H29ClN4O2S, CAS 1009435-96-4](/s/KNGDOQKFLOYANO-UQQQWYQISA-N.svg)
(5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one
CAS 1009435-96-4C28H29ClN4O2S
![1-[(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide chemical structure, C27H26ClN5O3S, CAS 1008881-19-3](/s/RJEUUTDLOHTQCJ-HAHDFKILSA-N.svg)
1-[(5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide
CAS 1008881-19-3C27H26ClN5O3S
![(5E)-5-[[1-Phenyl-3-(4-propoxyphenyl)pyrazol-4-yl]methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one chemical structure, C27H28N4O2S, CAS 381699-57-6](/s/JPWHAIVNGDSAHT-HKOYGPOVSA-N.svg)
(5E)-5-[[1-Phenyl-3-(4-propoxyphenyl)pyrazol-4-yl]methylidene]-2-piperidin-1-yl-1,3-thiazol-4-one
CAS 381699-57-6C27H28N4O2S
![5-{(Z)-1-[1-Phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one chemical structure, C27H28N4O2S, CAS 1009189-43-8](/s/CFBOAWKQFZJJAL-MOHJPFBDSA-N.svg)
5-{(Z)-1-[1-Phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one
CAS 1009189-43-8C27H28N4O2S
![5-{(Z)-1-[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one chemical structure, C25H24N4O2S, CAS 1009436-84-3](/s/JKPRBBCONXVSOD-JWGURIENSA-N.svg)
5-{(Z)-1-[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one
CAS 1009436-84-3C25H24N4O2S
![5-{(Z)-1-[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one chemical structure, C28H30N4O2S, CAS 1009188-49-1](/s/RDBFQXAQDLRTHE-PLRJNAJWSA-N.svg)
5-{(Z)-1-[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-piperidino-1,3-thiazol-4-one
CAS 1009188-49-1C28H30N4O2S
![Ethyl 1-[(5Z)-5-{[3-(3-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxylate chemical structure, C29H30N4O4S, CAS 1009438-34-9](/s/XUZIIDJKSUAYDN-BWAHOGKJSA-N.svg)
Ethyl 1-[(5Z)-5-{[3-(3-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxylate
CAS 1009438-34-9C29H30N4O4S
![2-(4-Methylpiperidino)-5-{(Z)-1-[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4-one chemical structure, C28H30N4O2S, CAS 1009438-50-9](/s/FPHMTWBZCMGQRO-BWAHOGKJSA-N.svg)
2-(4-Methylpiperidino)-5-{(Z)-1-[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-1,3-thiazol-4-one
CAS 1009438-50-9C28H30N4O2S
![5-{(Z)-1-[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(4-methylpiperidino)-1,3-thiazol-4-one chemical structure, C26H26N4O2S, CAS 1008884-84-1](/s/JZDGTZCHWSOEJH-KQWNVCNZSA-N.svg)
5-{(Z)-1-[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(4-methylpiperidino)-1,3-thiazol-4-one
CAS 1008884-84-1C26H26N4O2S
![N,N-Dimethyl-3-{4-[2-(4-methyl-piperidin-1-yl)-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-1-phenyl-1H-pyrazo l-3-yl}-benzenesulfonamide chemical structure, C27H29N5O3S2, CAS 1164519-90-7](/s/ZOFMHSZGAINRQK-ULJHMMPZSA-N.svg)
N,N-Dimethyl-3-{4-[2-(4-methyl-piperidin-1-yl)-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-1-phenyl-1H-pyrazo l-3-yl}-benzenesulfonamide
CAS 1164519-90-7C27H29N5O3S2
- N,N-Diethyl-3-{4-[4-oxo-2-piperidin-1-yl-4H-thiazol-(5Z)-ylidenemethyl]-1-phenyl-1H-pyrazol-3-yl}-benze nesulfonamide958984-59-3C28H31N5O3S2
- (5Z)-5-{[3-(4-Butoxy-3-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one1009436-25-2C29H31ClN4O2S
- (5Z)-2-(3-Methylpiperidin-1-yl)-5-({1-phenyl-3-[4-(propylsulfanyl)phenyl]-1H-pyrazol-4-yl}methylidene)-1,3-thiazol-4(5H)-one1008877-98-2C28H30N4OS2
- 5-{(Z)-1-[3-(3-Ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylpiperidino)-1,3-thiazol-4-one1008882-36-7C27H28N4O2S
- (5Z)-5-{[3-(3-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one1008884-76-1C29H32N4O2S
- (Z)-1-(5-((3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-oxo-4,5-dihydrothiazol-2-yl)piperidine-4-carboxamide1008881-43-3C28H28ClN5O3S
- Ethyl 1-[(5Z)-4-oxo-5-{[1-phenyl-3-(3-propoxyphenyl)-1H-pyrazol-4-yl]methylidene}-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxylate1008884-08-9C30H32N4O4S
- (5Z)-5-{[3-(3-Chloro-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one1008881-02-4C28H29ClN4O2S
- (5Z)-5-({3-[4-(Butylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-2-(3-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one955900-35-3C29H32N4OS2
- (5Z)-5-{[3-(4-Butoxy-3-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(4-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one1008881-35-3C29H31ClN4O2S
- (5Z)-5-((3-(4-Butoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-(1-piperidinyl)-1,3-thiazol-4(5H)-one378770-91-3C28H30N4O2S
- (5Z)-5-{[3-(3-Chloro-4-ethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylpiperidin-1-yl)-1,3-thiazol-4(5H)-one1009436-01-4C27H27ClN4O2S
- Ethyl 1-{(5E)-5-[(1,3-diphenyl-1H-pyrazol-4-yl)methylene]-4-oxo-4,5-dihydro-1,3-thiazol-2-YL}-4-piperidinecarboxylate623933-17-5C27H26N4O3S
- 1-[(5Z)-5-({3-[4-(Ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide1008878-93-0C27H27N5O2S2
- Ethyl 1-[(5Z)-5-{[3-(3-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxylate1008883-67-7C28H28N4O4S
- Ethyl 1-[(5Z)-5-({3-[4-(ethylsulfanyl)phenyl]-1-phenyl-1H-pyrazol-4-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxylate1009433-92-4C29H30N4O3S2
- 5-{(Z)-1-[3-(3-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2-(3-methylpiperidino)-1,3-thiazol-4-one1009436-41-2C26H26N4O2S
Related scaffolds
Same ring framework with different atoms or bond orders
