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Murcko scaffold

Ring system with 4 rings and 29 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
16
With full pages
3
Scaffold SMILES

O=C(CN1C(=O)SC(=Cc2ccc(-c3ccccc3)o2)C1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)SC(=Cc2ccc(-c3ccccc3)o2)C1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-[5-[(Z)-[3-[2-(4-Fluoroanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]-2-methylbenzoic acid chemical structure, C24H17FN2O6S, CAS 592539-21-4
3-[5-[(Z)-[3-[2-(4-Fluoroanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]-2-methylbenzoic acid
CAS 592539-21-4C24H17FN2O6S
Methyl 4-{5-[(Z)-(3-{2-[(2-fluorophenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-3-methylbenzoate chemical structure, C25H19FN2O6S, CAS 432007-76-6
Methyl 4-{5-[(Z)-(3-{2-[(2-fluorophenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-3-methylbenzoate
CAS 432007-76-6C25H19FN2O6S
2-Methyl-3-{5-[(3-{2-[(4-methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid chemical structure, C25H20N2O6S, CAS 1164479-27-9
2-Methyl-3-{5-[(3-{2-[(4-methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid
CAS 1164479-27-9C25H20N2O6S
3-{5-[(3-{2-[(4-Methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid chemical structure, C24H18N2O6S, CAS 430470-21-6
3-{5-[(3-{2-[(4-Methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}benzoic acid
CAS 430470-21-6C24H18N2O6S
2-Chloro-5-[5-[(E)-[3-[2-(4-methylanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoic acid chemical structure, C24H17ClN2O6S, CAS 431914-42-0
2-Chloro-5-[5-[(E)-[3-[2-(4-methylanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoic acid
CAS 431914-42-0C24H17ClN2O6S
(E)-2-Chloro-4-(5-((2,4-dioxo-3-(2-oxo-2-(p-tolylamino)ethyl)thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid chemical structure, C24H17ClN2O6S, CAS 430471-43-5
(E)-2-Chloro-4-(5-((2,4-dioxo-3-(2-oxo-2-(p-tolylamino)ethyl)thiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid
CAS 430471-43-5C24H17ClN2O6S
2-[(5E)-5-[[5-(4-Chloro-3-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3-methylphenyl)acetamide chemical structure, C23H16ClN3O6S, CAS 431065-99-5
2-[(5E)-5-[[5-(4-Chloro-3-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3-methylphenyl)acetamide
CAS 431065-99-5C23H16ClN3O6S
2-[(5E)-5-[[5-(4-Bromophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C23H17BrN2O4S, CAS 431924-10-6
2-[(5E)-5-[[5-(4-Bromophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
CAS 431924-10-6C23H17BrN2O4S
4-{5-[(E)-(3-{2-[(3,4-Dimethylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-3-methylbenzoic acid chemical structure, C26H22N2O6S, CAS 431930-80-2
4-{5-[(E)-(3-{2-[(3,4-Dimethylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-3-methylbenzoic acid
CAS 431930-80-2C26H22N2O6S
2-[(5E)-5-[[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C22H13Cl2FN2O4S, CAS 431927-57-0
2-[(5E)-5-[[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431927-57-0C22H13Cl2FN2O4S
N-(4-Methylphenyl)-2-[(5E)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C23H17N3O6S, CAS 432008-51-0
N-(4-Methylphenyl)-2-[(5E)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 432008-51-0C23H17N3O6S
N-(2-Fluorophenyl)-2-[(5Z)-5-[[5-(2-methoxy-5-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C23H16FN3O7S, CAS 432014-98-7
N-(2-Fluorophenyl)-2-[(5Z)-5-[[5-(2-methoxy-5-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 432014-98-7C23H16FN3O7S
2-Chloro-5-{5-[(E)-(3-{2-[(3-methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}benzoic acid chemical structure, C24H17ClN2O6S, CAS 432017-78-2
2-Chloro-5-{5-[(E)-(3-{2-[(3-methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}benzoic acid
CAS 432017-78-2C24H17ClN2O6S
3-{5-[(3-{2-[(3,4-Dimethylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}-4-methylbenzoic acid chemical structure, C26H22N2O6S, CAS 1164479-41-7
3-{5-[(3-{2-[(3,4-Dimethylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}-4-methylbenzoic acid
CAS 1164479-41-7C26H22N2O6S
N-(3,4-Dimethylphenyl)-2-[(5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C24H19FN2O4S, CAS 432502-28-8
N-(3,4-Dimethylphenyl)-2-[(5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 432502-28-8C24H19FN2O4S
N-(3,4-Dimethylphenyl)-2-[(5E)-5-[[5-(4-methyl-3-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C25H21N3O6S, CAS 433238-41-6
N-(3,4-Dimethylphenyl)-2-[(5E)-5-[[5-(4-methyl-3-nitrophenyl)furan-2-yl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 433238-41-6C25H21N3O6S