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Murcko scaffold

1-(Bicyclo(1.1.1)pentan-1-yl)piperazine scaffold

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
11
Chemicals
9
With full pages
1
Scaffold SMILES

C1CN(C23CC(C2)C3)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Bicyclo(1.1.1)pentan-1-yl)piperazine page
Murcko scaffold C1CN(C23CC(C2)C3)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

1-(Bicyclo(1.1.1)pentan-1-yl)piperazine chemical structure, C9H16N2, CAS 2167346-89-4
1-(Bicyclo(1.1.1)pentan-1-yl)piperazine
CAS 2167346-89-4C9H16N2
1-(Bicyclo[1.1.1]pentan-1-yl)piperazine hydrochloride chemical structure, C9H17ClN2, CAS 2187435-44-3
1-(Bicyclo[1.1.1]pentan-1-yl)piperazine hydrochloride
CAS 2187435-44-3C9H17ClN2
tert-Butyl (3-(piperazin-1-yl)bicyclo[1.1.1]pentan-1-yl)carbamate chemical structure, C14H25N3O2, CAS 2227205-14-1
tert-Butyl (3-(piperazin-1-yl)bicyclo[1.1.1]pentan-1-yl)carbamate
CAS 2227205-14-1C14H25N3O2
3-(4-Methylpiperazin-1-yl)bicyclo[1.1.1]pentan-1-amine chemical structure, C10H19N3, CAS 2227205-33-4
3-(4-Methylpiperazin-1-yl)bicyclo[1.1.1]pentan-1-amine
CAS 2227205-33-4C10H19N3
3-(4-Methylpiperazin-1-yl)bicyclo[1.1.1]pentan-1-amine dihydrochloride chemical structure, C10H21Cl2N3, CAS 2227205-34-5
3-(4-Methylpiperazin-1-yl)bicyclo[1.1.1]pentan-1-amine dihydrochloride
CAS 2227205-34-5C10H21Cl2N3
tert-Butyl 4-{bicyclo[1.1.1]pentan-1-yl}piperazine-1-carboxylate chemical structure, C14H24N2O2, CAS 2680534-60-3
tert-Butyl 4-{bicyclo[1.1.1]pentan-1-yl}piperazine-1-carboxylate
CAS 2680534-60-3C14H24N2O2
tert-Butyl 4-{3-aminobicyclo[1.1.1]pentan-1-yl}piperazine-1-carboxylate chemical structure, C14H25N3O2, CAS 2227205-38-9
tert-Butyl 4-{3-aminobicyclo[1.1.1]pentan-1-yl}piperazine-1-carboxylate
CAS 2227205-38-9C14H25N3O2
1-(3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)piperazine chemical structure, C10H15F3N2, CAS 2663696-91-9
1-(3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)piperazine
CAS 2663696-91-9C10H15F3N2
tert-Butyl 4-(3-(methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl)piperazine-1-carboxylate chemical structure, C16H26N2O4, CAS 3043903-40-5
tert-Butyl 4-(3-(methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl)piperazine-1-carboxylate
CAS 3043903-40-5C16H26N2O4