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Murcko scaffold

Ring system with 4 rings and 24 atoms

15 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
15
With full pages
3
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2ccc3ccccc3n2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(c2ccc3ccccc3n2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

(4-Quinolin-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone chemical structure, C23H25N3O4, CAS 292841-50-0
(4-Quinolin-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone
CAS 292841-50-0C23H25N3O4
(4-Chlorophenyl)-[4-(5,8-dimethoxy-4-methylquinolin-2-yl)piperazin-1-yl]methanone chemical structure, C23H24ClN3O3, CAS 717831-03-3
(4-Chlorophenyl)-[4-(5,8-dimethoxy-4-methylquinolin-2-yl)piperazin-1-yl]methanone
CAS 717831-03-3C23H24ClN3O3
2-[4-(4-Fluorobenzoyl)-1-piperazinyl]-5,8-dimethoxy-4-methylquinoline chemical structure, C23H24FN3O3, CAS 774551-45-0
2-[4-(4-Fluorobenzoyl)-1-piperazinyl]-5,8-dimethoxy-4-methylquinoline
CAS 774551-45-0C23H24FN3O3
Piperazine, 1-(2-quinolinyl)-4-(3,4,5-trimethoxybenzoyl)-, monohydrochloride chemical structure, C23H26ClN3O4, CAS 101153-56-4
Piperazine, 1-(2-quinolinyl)-4-(3,4,5-trimethoxybenzoyl)-, monohydrochloride
CAS 101153-56-4C23H26ClN3O4
[4-(4-Amino-6,7-dimethoxyquinolin-2-yl)piperazin-1-yl](phenyl)methanone chemical structure, C22H24N4O3, CAS 113704-35-1
[4-(4-Amino-6,7-dimethoxyquinolin-2-yl)piperazin-1-yl](phenyl)methanone
CAS 113704-35-1C22H24N4O3
(3-Fluorophenyl)[4-(4-methylquinolin-2-yl)piperazin-1-yl]methanone chemical structure, C21H20FN3O, CAS 929855-58-3
(3-Fluorophenyl)[4-(4-methylquinolin-2-yl)piperazin-1-yl]methanone
CAS 929855-58-3C21H20FN3O
N-(3-{[4-(4-Methylquinolin-2-yl)piperazin-1-yl]carbonyl}phenyl)acetamide chemical structure, C23H24N4O2, CAS 921115-85-7
N-(3-{[4-(4-Methylquinolin-2-yl)piperazin-1-yl]carbonyl}phenyl)acetamide
CAS 921115-85-7C23H24N4O2
1-(2-{[4-(4-Methylquinolin-2-yl)piperazin-1-yl]carbonyl}phenyl)ethanone chemical structure, C23H23N3O2, CAS 921056-82-8
1-(2-{[4-(4-Methylquinolin-2-yl)piperazin-1-yl]carbonyl}phenyl)ethanone
CAS 921056-82-8C23H23N3O2
2-[4-(4-Chlorobenzoyl)piperazin-1-yl]-4-methylquinoline chemical structure, C21H20ClN3O, CAS 920479-85-2
2-[4-(4-Chlorobenzoyl)piperazin-1-yl]-4-methylquinoline
CAS 920479-85-2C21H20ClN3O
4-Methyl-2-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]quinoline chemical structure, C24H27N3O4, CAS 920457-12-1
4-Methyl-2-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]quinoline
CAS 920457-12-1C24H27N3O4
2-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-4-methylquinoline chemical structure, C23H25N3O3, CAS 921116-49-6
2-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-4-methylquinoline
CAS 921116-49-6C23H25N3O3
2-[4-(3-Methoxybenzoyl)piperazin-1-yl]-4-methylquinoline chemical structure, C22H23N3O2, CAS 929820-84-8
2-[4-(3-Methoxybenzoyl)piperazin-1-yl]-4-methylquinoline
CAS 929820-84-8C22H23N3O2
2-[4-(4-Methoxybenzoyl)piperazin-1-yl]-4-methylquinoline chemical structure, C22H23N3O2, CAS 929835-87-0
2-[4-(4-Methoxybenzoyl)piperazin-1-yl]-4-methylquinoline
CAS 929835-87-0C22H23N3O2
N-(2-{[4-(4-Methyl-2-quinolyl)piperazino]carbonyl}phenyl)acetamide chemical structure, C23H24N4O2, CAS 929966-55-2
N-(2-{[4-(4-Methyl-2-quinolyl)piperazino]carbonyl}phenyl)acetamide
CAS 929966-55-2C23H24N4O2
2-(4-Benzoylpiperazin-1-yl)-4-methylquinoline chemical structure, C21H21N3O, CAS 449780-98-7
2-(4-Benzoylpiperazin-1-yl)-4-methylquinoline
CAS 449780-98-7C21H21N3O