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Murcko scaffold

Ring system with 3 rings and 14 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
16
With full pages
9
Scaffold SMILES

C1=CC(c2cccs2)c2c[nH]nc2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1=CC(c2cccs2)c2c[nH]nc2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

6-Amino-3-(methoxymethyl)-4-(3-methylthiophen-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H14N4O2S, CAS 5762-55-0
6-Amino-3-(methoxymethyl)-4-(3-methylthiophen-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 5762-55-0C14H14N4O2S
6-Amino-4-(5-bromothiophen-2-yl)-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C13H11BrN4OS, CAS 340812-36-4
6-Amino-4-(5-bromothiophen-2-yl)-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 340812-36-4C13H11BrN4OS
6-Amino-3-methyl-4-(thiophen-2-yl)-1H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C12H10N4OS, CAS 87736-62-7
6-Amino-3-methyl-4-(thiophen-2-yl)-1H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile
CAS 87736-62-7C12H10N4OS
6-Amino-4-(4-bromo-2-thienyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C12H9BrN4OS, CAS 293766-42-4
6-Amino-4-(4-bromo-2-thienyl)-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 293766-42-4C12H9BrN4OS
6-Amino-3-tert-butyl-4-(5-methyl-2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C16H18N4OS, CAS 309289-81-4
6-Amino-3-tert-butyl-4-(5-methyl-2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 309289-81-4C16H18N4OS
6-Amino-3-tert-butyl-4-(2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H16N4OS, CAS 313379-43-0
6-Amino-3-tert-butyl-4-(2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 313379-43-0C15H16N4OS
6-Amino-3-tert-butyl-4-(3-methyl-2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C16H18N4OS, CAS 316361-85-0
6-Amino-3-tert-butyl-4-(3-methyl-2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 316361-85-0C16H18N4OS
6-Amino-4-(3-methylthiophen-2-yl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H16N4OS, CAS 340807-50-3
6-Amino-4-(3-methylthiophen-2-yl)-3-propyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 340807-50-3C15H16N4OS
6-Amino-3-(methoxymethyl)-4-(2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C13H12N4O2S, CAS 353461-49-1
6-Amino-3-(methoxymethyl)-4-(2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 353461-49-1C13H12N4O2S
6-Amino-4-(4-bromothiophen-2-yl)-3-butyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H15BrN4OS, CAS 664999-83-1
6-Amino-4-(4-bromothiophen-2-yl)-3-butyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 664999-83-1C15H15BrN4OS
6-Amino-4-(5-chlorothiophen-2-yl)-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C13H11ClN4OS, CAS 665000-28-2
6-Amino-4-(5-chlorothiophen-2-yl)-3-ethyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 665000-28-2C13H11ClN4OS
6-Amino-3-propyl-4-(2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H14N4OS, CAS 316360-38-0
6-Amino-3-propyl-4-(2-thienyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 316360-38-0C14H14N4OS
6-Amino-3-methyl-4-(3-methylthiophen-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C13H12N4OS, CAS 309926-68-9
6-Amino-3-methyl-4-(3-methylthiophen-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 309926-68-9C13H12N4OS
6-Amino-4-(5-bromo-2-thienyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C14H13BrN4OS, CAS 315246-48-1
6-Amino-4-(5-bromo-2-thienyl)-3-propyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 315246-48-1C14H13BrN4OS
6-Amino-4-(5-bromothiophen-2-yl)-3-tert-butyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C15H15BrN4OS, CAS 340812-32-0
6-Amino-4-(5-bromothiophen-2-yl)-3-tert-butyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 340812-32-0C15H15BrN4OS
6-Amino-4-(5-bromothiophen-2-yl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C13H11BrN4O2S, CAS 6926-87-0
6-Amino-4-(5-bromothiophen-2-yl)-3-(methoxymethyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
CAS 6926-87-0C13H11BrN4O2S