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Murcko scaffold

Ring system with 4 rings and 28 atoms

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
7
With full pages
1
Scaffold SMILES

O=S(=O)(C=Cc1cn(-c2ccccc2)nc1-c1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(C=Cc1cn(-c2ccccc2)nc1-c1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

(E)-2-(Benzenesulfonyl)-3-[3-(3,4-dimethoxyphenyl)-1-phenylpyrazol-4-yl]prop-2-enenitrile chemical structure, C26H21N3O4S, CAS 956202-76-9
(E)-2-(Benzenesulfonyl)-3-[3-(3,4-dimethoxyphenyl)-1-phenylpyrazol-4-yl]prop-2-enenitrile
CAS 956202-76-9C26H21N3O4S
(E)-3-(3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(phenylsulfonyl)acrylonitrile chemical structure, C25H18ClN3O3S, CAS 957014-00-5
(E)-3-(3-(3-Chloro-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(phenylsulfonyl)acrylonitrile
CAS 957014-00-5C25H18ClN3O3S
3-(3-(3-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(phenylsulfonyl)acrylonitrile chemical structure, C28H25N3O3S, CAS 370573-09-4
3-(3-(3-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(phenylsulfonyl)acrylonitrile
CAS 370573-09-4C28H25N3O3S
2-((4-Chlorophenyl)sulfonyl)-3-(1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)acrylonitrile chemical structure, C27H22ClN3O3S, CAS 383370-60-3
2-((4-Chlorophenyl)sulfonyl)-3-(1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)acrylonitrile
CAS 383370-60-3C27H22ClN3O3S
2-((4-Chlorophenyl)sulfonyl)-3-(3-(4-isopropoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile chemical structure, C27H22ClN3O3S, CAS 378758-24-8
2-((4-Chlorophenyl)sulfonyl)-3-(3-(4-isopropoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile
CAS 378758-24-8C27H22ClN3O3S
2-((4-Chlorophenyl)sulfonyl)-3-(3-(4-ethoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile chemical structure, C27H22ClN3O3S, CAS 381206-86-6
2-((4-Chlorophenyl)sulfonyl)-3-(3-(4-ethoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile
CAS 381206-86-6C27H22ClN3O3S
2-((4-Chlorophenyl)sulfonyl)-3-(3-(4-(ethylthio)phenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile chemical structure, C26H20ClN3O2S2, CAS 1009434-04-1
2-((4-Chlorophenyl)sulfonyl)-3-(3-(4-(ethylthio)phenyl)-1-phenyl-1H-pyrazol-4-yl)acrylonitrile
CAS 1009434-04-1C26H20ClN3O2S2