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Murcko scaffold

Ring system with 4 rings and 27 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
9
With full pages
1
Scaffold SMILES

O=C(C=Cc1cn(-c2ccccc2)nc1-c1ccccc1)N1CCOCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1cn(-c2ccccc2)nc1-c1ccccc1)N1CCOCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

(2E)-3-(1,3-Diphenyl-1H-pyrazol-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one chemical structure, C22H21N3O2, CAS 313049-85-3
(2E)-3-(1,3-Diphenyl-1H-pyrazol-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one
CAS 313049-85-3C22H21N3O2
(Z)-2-(Morpholine-4-carbonyl)-3-[1-phenyl-3-(4-propylsulfanyl-phenyl)-1H-pyrazol-4-yl]-acrylonitrile chemical structure, C26H26N4O2S, CAS 1164497-15-7
(Z)-2-(Morpholine-4-carbonyl)-3-[1-phenyl-3-(4-propylsulfanyl-phenyl)-1H-pyrazol-4-yl]-acrylonitrile
CAS 1164497-15-7C26H26N4O2S
3-(3-(4-Butoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile chemical structure, C28H30N4O3, CAS 380593-32-8
3-(3-(4-Butoxy-3-methylphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile
CAS 380593-32-8C28H30N4O3
3-(3-(3-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile chemical structure, C27H28N4O3, CAS 380585-11-5
3-(3-(3-Methyl-4-propoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile
CAS 380585-11-5C27H28N4O3
3-(3-(4-Isopropoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile chemical structure, C26H26N4O3, CAS 380564-96-5
3-(3-(4-Isopropoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile
CAS 380564-96-5C26H26N4O3
3-(3-(4-(Ethylthio)phenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile chemical structure, C25H24N4O2S, CAS 1009186-77-9
3-(3-(4-(Ethylthio)phenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile
CAS 1009186-77-9C25H24N4O2S
(2Z)-3-[3-(4-Butoxy-3-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2-(morpholin-4-ylcarbonyl)prop-2-enenitrile chemical structure, C27H27FN4O3, CAS 956948-33-7
(2Z)-3-[3-(4-Butoxy-3-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2-(morpholin-4-ylcarbonyl)prop-2-enenitrile
CAS 956948-33-7C27H27FN4O3
2-(Morpholine-4-carbonyl)-3-(1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)acrylonitrile chemical structure, C26H26N4O3, CAS 1017490-14-0
2-(Morpholine-4-carbonyl)-3-(1-phenyl-3-(4-propoxyphenyl)-1H-pyrazol-4-yl)acrylonitrile
CAS 1017490-14-0C26H26N4O3
3-(3-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile chemical structure, C24H22N4O3, CAS 1017500-86-5
3-(3-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-2-(morpholine-4-carbonyl)acrylonitrile
CAS 1017500-86-5C24H22N4O3