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Murcko scaffold

Ring system with 4 rings and 27 atoms

16 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 27
Chemicals: 16
With full pages: 1

Scaffold SMILES

O=C(C=Cc1cn(-c2ccccc2)nc1-c1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1cn(-c2ccccc2)nc1-c1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-[3-(3-Bromo-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-1-(4-chlorophenyl)-2-propen-1-one chemical structure, C25H18BrClN2O2, CAS 313273-05-1

3-[3-(3-Bromo-4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-1-(4-chlorophenyl)-2-propen-1-one

CAS 313273-05-1C₂₅H₁₈BrClN₂O₂

(2E)-3-(1,3-Diphenyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one chemical structure, C25H20N2O2, CAS 1264279-98-2

(2E)-3-(1,3-Diphenyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one

CAS 1264279-98-2C₂₅H₂₀N₂O₂

(E)-3-(1,3-Diphenylpyrazol-4-yl)-1-phenylprop-2-en-1-one chemical structure, C24H18N2O, CAS 905441-76-1

(E)-3-(1,3-Diphenylpyrazol-4-yl)-1-phenylprop-2-en-1-one

CAS 905441-76-1C₂₄H₁₈N₂O

1-(4-Chlorophenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-propen-1-one chemical structure, C24H17ClN2O, CAS 312601-53-9

1-(4-Chlorophenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-propen-1-one

CAS 312601-53-9C₂₄H₁₇ClN₂O

3-(1,3-Diphenyl-1H-pyrazol-4-yl)-1-(4-methylphenyl)-2-propen-1-one chemical structure, C25H20N2O, CAS 1228954-06-0

3-(1,3-Diphenyl-1H-pyrazol-4-yl)-1-(4-methylphenyl)-2-propen-1-one

CAS 1228954-06-0C₂₅H₂₀N₂O

(2E)-3-[3-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-1-phenyl-2-propen-1-one chemical structure, C25H20N2O2, CAS 1498233-87-6

(2E)-3-[3-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-1-phenyl-2-propen-1-one

CAS 1498233-87-6C₂₅H₂₀N₂O₂

(E)-1-(4-Chlorophenyl)-3-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2-propen-1-one chemical structure, C24H16Cl2N2O, CAS 1239732-62-7

(E)-1-(4-Chlorophenyl)-3-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2-propen-1-one

CAS 1239732-62-7C₂₄H₁₆Cl₂N₂O

(2E)-3-[3-(4-Ethoxyphenyl)-1-phenylpyrazol-4-yl]-1-phenylprop-2-en-1-one chemical structure, C26H22N2O2, CAS 313273-36-8

(2E)-3-[3-(4-Ethoxyphenyl)-1-phenylpyrazol-4-yl]-1-phenylprop-2-en-1-one

CAS 313273-36-8C₂₆H₂₂N₂O₂

(E)-1-(3-Bromo-4-methoxyphenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-propen-1-one chemical structure, C25H19BrN2O2, CAS 312601-67-5

(E)-1-(3-Bromo-4-methoxyphenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-propen-1-one

CAS 312601-67-5C₂₅H₁₉BrN₂O₂

(E)-1-(4-Chlorophenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-propen-1-one chemical structure, C25H19ClN2O, CAS 313362-44-6

(E)-1-(4-Chlorophenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]-2-propen-1-one

CAS 313362-44-6C₂₅H₁₉ClN₂O

(2E)-1-(4-Methoxyphenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one chemical structure, C26H22N2O2, CAS 313362-07-1

(2E)-1-(4-Methoxyphenyl)-3-[3-(4-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one

CAS 313362-07-1C₂₆H₂₂N₂O₂

1-(4-Bromophenyl)-3-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one chemical structure, C24H16BrFN2O, CAS 2205929-94-6

1-(4-Bromophenyl)-3-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-en-1-one

CAS 2205929-94-6C₂₄H₁₆BrFN₂O

(2E)-2-Benzoyl-3-[3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enenitrile chemical structure, C27H21N3O3, CAS 957035-20-0

(2E)-2-Benzoyl-3-[3-(3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]prop-2-enenitrile

CAS 957035-20-0C₂₇H₂₁N₃O₃

(E)-3-(1,3-Diphenylpyrazol-4-yl)-1-(2-methoxyphenyl)prop-2-en-1-one chemical structure, C25H20N2O2, CAS 391868-49-8

(E)-3-(1,3-Diphenylpyrazol-4-yl)-1-(2-methoxyphenyl)prop-2-en-1-one

CAS 391868-49-8C₂₅H₂₀N₂O₂

(Z)-3-[3-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-1-[3-(trifluoromethyl)phenyl]-2-propen-1-one chemical structure, C27H21F3N2O3, CAS 956923-16-3

(Z)-3-[3-(3,4-Dimethoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]-1-[3-(trifluoromethyl)phenyl]-2-propen-1-one

CAS 956923-16-3C₂₇H₂₁F₃N₂O₃

1-(2-Aminophenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)prop-2-en-1-one chemical structure, C24H19N3O, CAS 917980-77-9

1-(2-Aminophenyl)-3-(1,3-diphenyl-1H-pyrazol-4-yl)prop-2-en-1-one

CAS 917980-77-9C₂₄H₁₉N₃O