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Murcko scaffold

N''-Cyclohexyl-N-quinolin-4(1H)-ylidene-N'-1,3-thiazol-2-ylguanidine scaffold

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
20
With full pages
1
Scaffold SMILES

c1ccc2c(NC(=NC3CCCCC3)Nc3nccs3)ccnc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N''-Cyclohexyl-N-quinolin-4(1H)-ylidene-N'-1,3-thiazol-2-ylguanidine page
Murcko scaffold c1ccc2c(NC(=NC3CCCCC3)Nc3nccs3)ccnc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

Timegadine chemical structure, C20H23N5S, CAS 71079-19-1
Timegadine
CAS 71079-19-1C20H23N5S
N''-Cyclohexyl-N-(2-methylquinolin-4(1H)-ylidene)-N'-(4-methyl-1,3-thiazol-2-yl)guanidine chemical structure, C21H25N5S, CAS 71079-20-4
N''-Cyclohexyl-N-(2-methylquinolin-4(1H)-ylidene)-N'-(4-methyl-1,3-thiazol-2-yl)guanidine
CAS 71079-20-4C21H25N5S
Guanidine, N-cyclohexyl-N'-(4,5-dimethyl-2-thiazolyl)-N''-(2-methyl-4-quinolinyl)- chemical structure, C22H27N5S, CAS 71079-21-5
Guanidine, N-cyclohexyl-N'-(4,5-dimethyl-2-thiazolyl)-N''-(2-methyl-4-quinolinyl)-
CAS 71079-21-5C22H27N5S
4-Thiazolecarboxylic acid, 2-(((cyclohexylamino)((2-methyl-4-quinolinyl)amino)methylene)amino)-, ethyl ester chemical structure, C23H27N5O2S, CAS 71079-22-6
4-Thiazolecarboxylic acid, 2-(((cyclohexylamino)((2-methyl-4-quinolinyl)amino)methylene)amino)-, ethyl ester
CAS 71079-22-6C23H27N5O2S
5-Thiazolecarboxylic acid, 2-(((cyclohexylamino)((2-methyl-4-quinolinyl)amino)methylene)amino)-, ethyl ester chemical structure, C23H27N5O2S, CAS 71079-23-7
5-Thiazolecarboxylic acid, 2-(((cyclohexylamino)((2-methyl-4-quinolinyl)amino)methylene)amino)-, ethyl ester
CAS 71079-23-7C23H27N5O2S
4-Thiazolecarboxylic acid, 2-(((cyclohexylamino)((2-methyl-4-quinolinyl)amino)methylene)amino)- chemical structure, C21H23N5O2S, CAS 71079-24-8
4-Thiazolecarboxylic acid, 2-(((cyclohexylamino)((2-methyl-4-quinolinyl)amino)methylene)amino)-
CAS 71079-24-8C21H23N5O2S
5-Thiazolecarboxylic acid, 2-((N-cyclohexyl-N'-(2-methyl-4-quinolyl)amidino)amino)-, dihydrate chemical structure, C21H23N5O2S, CAS 71079-25-9
5-Thiazolecarboxylic acid, 2-((N-cyclohexyl-N'-(2-methyl-4-quinolyl)amidino)amino)-, dihydrate
CAS 71079-25-9C21H23N5O2S
N''-(2,3-Dimethylcyclohexyl)-N-(2-methylquinolin-4(1H)-ylidene)-N'-1,3-thiazol-2-ylguanidine--hydrogen chloride (1/1) chemical structure, C22H28ClN5S, CAS 71079-61-3
N''-(2,3-Dimethylcyclohexyl)-N-(2-methylquinolin-4(1H)-ylidene)-N'-1,3-thiazol-2-ylguanidine--hydrogen chloride (1/1)
CAS 71079-61-3C22H28ClN5S
N''-Cyclohexyl-N-quinolin-4(1H)-ylidene-N'-1,3-thiazol-2-ylguanidine chemical structure, C19H21N5S, CAS 71079-76-0
N''-Cyclohexyl-N-quinolin-4(1H)-ylidene-N'-1,3-thiazol-2-ylguanidine
CAS 71079-76-0C19H21N5S
N''-Cyclohexyl-N-(2-ethylquinolin-4(1H)-ylidene)-N'-1,3-thiazol-2-ylguanidine chemical structure, C21H25N5S, CAS 71079-77-1
N''-Cyclohexyl-N-(2-ethylquinolin-4(1H)-ylidene)-N'-1,3-thiazol-2-ylguanidine
CAS 71079-77-1C21H25N5S
Guanidine, N-cyclohexyl-N'-(2-propyl-4-quinolinyl)-N''-2-thiazolyl- chemical structure, C22H27N5S, CAS 71079-78-2
Guanidine, N-cyclohexyl-N'-(2-propyl-4-quinolinyl)-N''-2-thiazolyl-
CAS 71079-78-2C22H27N5S
Guanidine, N-cyclohexyl-N'-(2-(1-methylethyl)-4-quinolinyl)-N''-2-thiazolyl- chemical structure, C22H27N5S, CAS 71079-79-3
Guanidine, N-cyclohexyl-N'-(2-(1-methylethyl)-4-quinolinyl)-N''-2-thiazolyl-
CAS 71079-79-3C22H27N5S
Guanidine, N-cyclohexyl-N'-(2-(2-methylpropyl)-4-quinolinyl)-N''-2-thiazolyl- chemical structure, C23H29N5S, CAS 71079-80-6
Guanidine, N-cyclohexyl-N'-(2-(2-methylpropyl)-4-quinolinyl)-N''-2-thiazolyl-
CAS 71079-80-6C23H29N5S
Guanidine, N-cyclohexyl-N'-(2,6-dimethyl-4-quinolinyl)-N''-2-thiazolyl- chemical structure, C21H25N5S, CAS 71079-82-8
Guanidine, N-cyclohexyl-N'-(2,6-dimethyl-4-quinolinyl)-N''-2-thiazolyl-
CAS 71079-82-8C21H25N5S
Guanidine, N-(7-chloro-4-quinolinyl)-N'-cyclohexyl-N''-2-thiazolyl- chemical structure, C19H20ClN5S, CAS 71079-84-0
Guanidine, N-(7-chloro-4-quinolinyl)-N'-cyclohexyl-N''-2-thiazolyl-
CAS 71079-84-0C19H20ClN5S
Guanidine, N-(3-chloro-2-methyl-4-quinolinyl)-N'-cyclohexyl-N''-2-thiazolyl- chemical structure, C20H22ClN5S, CAS 71079-85-1
Guanidine, N-(3-chloro-2-methyl-4-quinolinyl)-N'-cyclohexyl-N''-2-thiazolyl-
CAS 71079-85-1C20H22ClN5S
Guanidine, N-(4-methylcyclohexyl)-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolyl- chemical structure, C21H25N5S, CAS 71132-09-7
Guanidine, N-(4-methylcyclohexyl)-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolyl-
CAS 71132-09-7C21H25N5S
Guanidine, N-(2,3-diethylcyclohexyl)-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolyl-, monohydrochloride chemical structure, C24H32ClN5S, CAS 72042-01-4
Guanidine, N-(2,3-diethylcyclohexyl)-N'-(2-methyl-4-quinolinyl)-N''-2-thiazolyl-, monohydrochloride
CAS 72042-01-4C24H32ClN5S
Guanidine, N-cyclohexyl-N'-(6-methyl-4-quinolinyl)-N''-2-thiazolyl- chemical structure, C20H23N5S, CAS 72042-11-6
Guanidine, N-cyclohexyl-N'-(6-methyl-4-quinolinyl)-N''-2-thiazolyl-
CAS 72042-11-6C20H23N5S
N-Cyclohexyl-N'-(2-methyl-4-quinolineyl)-N''-thiazol-2-ylguanidinemonohydrochloride chemical structure, C20H24ClN5S, CAS 71080-06-3
N-Cyclohexyl-N'-(2-methyl-4-quinolineyl)-N''-thiazol-2-ylguanidinemonohydrochloride
CAS 71080-06-3C20H24ClN5S