Murcko scaffold
1-Benzylsulfonylpyrrolidine scaffold
42 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 15
- Chemicals
- 42
- With full pages
- 5
Scaffold SMILES
O=S(=O)(Cc1ccccc1)N1CCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 42 of 42 chemicals
1-(Benzylsulfonyl)-4-hydroxyproline
CAS 7469-25-2C12H15NO5S
1-Benzylsulfonylpyrrolidine
CAS 10321-62-7C11H15NO2S
![1-[(4-Chlorobenzyl)sulfonyl]pyrrolidine chemical structure, C11H14ClNO2S, CAS 827619-86-3](/s/VDYPIECQOSBQTB-UHFFFAOYSA-N.svg)
1-[(4-Chlorobenzyl)sulfonyl]pyrrolidine
CAS 827619-86-3C11H14ClNO2S
![1-[(2-Chlorobenzyl)sulfonyl]pyrrolidine chemical structure, C11H14ClNO2S, CAS 827621-55-6](/s/LOTMPQMAZIXJIH-UHFFFAOYSA-N.svg)
1-[(2-Chlorobenzyl)sulfonyl]pyrrolidine
CAS 827621-55-6C11H14ClNO2S
1-(((4-Hydrazinylphenyl)methyl)sulfonyl)pyrrolidine
CAS 181178-23-4C11H17N3O2S
1-Phenylmethanesulfonylpyrrolidine-2-carboxylic acid
CAS 100391-96-6C12H15NO4S
4-((1-Pyrrolidinylsulfonyl)methyl)benzenamine
CAS 334981-10-1C11H16N2O2S
1-((4-Nitrobenzyl)sulfonyl)pyrrolidine
CAS 340041-91-0C11H14N2O4S
![1-[(3-Chlorobenzyl)sulfonyl]pyrrolidine chemical structure, C11H14ClNO2S, CAS 950251-52-2](/s/GNFMRDWDCUIPHG-UHFFFAOYSA-N.svg)
1-[(3-Chlorobenzyl)sulfonyl]pyrrolidine
CAS 950251-52-2C11H14ClNO2S
![1-[(2-Fluorobenzyl)sulfonyl]pyrrolidine chemical structure, C11H14FNO2S, CAS 950232-55-0](/s/KQSDMOHFYMRFLK-UHFFFAOYSA-N.svg)
1-[(2-Fluorobenzyl)sulfonyl]pyrrolidine
CAS 950232-55-0C11H14FNO2S
1-(4-Bromobenzylsulfonyl)pyrrolidine
CAS 950255-92-2C11H14BrNO2S
![1-[(2-Chloro-6-fluorobenzyl)sulfonyl]pyrrolidine chemical structure, C11H13ClFNO2S, CAS 950244-47-0](/s/YIBZLIDFIABTNN-UHFFFAOYSA-N.svg)
1-[(2-Chloro-6-fluorobenzyl)sulfonyl]pyrrolidine
CAS 950244-47-0C11H13ClFNO2S
![1-[(3-Methylbenzyl)sulfonyl]pyrrolidine chemical structure, C12H17NO2S, CAS 950256-78-7](/s/VKPKFELOZMKSDK-UHFFFAOYSA-N.svg)
1-[(3-Methylbenzyl)sulfonyl]pyrrolidine
CAS 950256-78-7C12H17NO2S
![1-[(3-Nitrophenyl)methanesulfonyl]pyrrolidine chemical structure, C11H14N2O4S, CAS 864685-23-4](/s/XRCGXTVCSRFBJW-UHFFFAOYSA-N.svg)
1-[(3-Nitrophenyl)methanesulfonyl]pyrrolidine
CAS 864685-23-4C11H14N2O4S
![4-[(Pyrrolidine-1-sulfonyl)methyl]benzonitrile chemical structure, C12H14N2O2S, CAS 1041561-96-9](/s/JWHAMFBBZFBYKU-UHFFFAOYSA-N.svg)
4-[(Pyrrolidine-1-sulfonyl)methyl]benzonitrile
CAS 1041561-96-9C12H14N2O2S
![2-[(Pyrrolidine-1-sulfonyl)methyl]benzonitrile chemical structure, C12H14N2O2S, CAS 1036513-85-5](/s/JCEKCAOEHWSOIG-UHFFFAOYSA-N.svg)
2-[(Pyrrolidine-1-sulfonyl)methyl]benzonitrile
CAS 1036513-85-5C12H14N2O2S
(2-((Pyrrolidin-1-ylsulfonyl)methyl)phenyl)methanamine
CAS 1041567-12-7C12H18N2O2S
![Methyl 4-[(pyrrolidine-1-sulfonyl)methyl]benzoate chemical structure, C13H17NO4S, CAS 1119407-35-0](/s/MCJNVETYYAJFEL-UHFFFAOYSA-N.svg)
Methyl 4-[(pyrrolidine-1-sulfonyl)methyl]benzoate
CAS 1119407-35-0C13H17NO4S
![4-[(Pyrrolidin-1-ylsulfonyl)methyl]benzoic acid chemical structure, C12H15NO4S, CAS 1098391-16-2](/s/LBXKCOPMMZAIMQ-UHFFFAOYSA-N.svg)
4-[(Pyrrolidin-1-ylsulfonyl)methyl]benzoic acid
CAS 1098391-16-2C12H15NO4S
3-((Pyrrolidin-1-ylsulfonyl)methyl)aniline
CAS 1095015-35-2C11H16N2O2S
![4-[(Pyrrolidin-1-ylsulfonyl)methyl]benzamide chemical structure, C12H16N2O3S, CAS 1158741-29-7](/s/UWHOBQCVFDYLHE-UHFFFAOYSA-N.svg)
4-[(Pyrrolidin-1-ylsulfonyl)methyl]benzamide
CAS 1158741-29-7C12H16N2O3S
![N,N-Dimethyl-4-[(pyrrolidin-1-ylsulfonyl)methyl]benzamide chemical structure, C14H20N2O3S, CAS 1083322-63-7](/s/RLVQDBRRUJDSII-UHFFFAOYSA-N.svg)
N,N-Dimethyl-4-[(pyrrolidin-1-ylsulfonyl)methyl]benzamide
CAS 1083322-63-7C14H20N2O3S
4-((Pyrrolidin-1-ylsulfonyl)methyl) benzenamine hydrochloride
CAS 1112206-13-9C11H17ClN2O2S
![Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1) chemical structure, C11H18ClN3O2S, CAS 334981-11-2](/s/KDPFNFGHCNPPAI-UHFFFAOYSA-N.svg)
Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1)
CAS 334981-11-2C11H18ClN3O2S
- 1-[(3-Bromophenyl)methylsulfonyl]pyrrolidine1160924-52-6C11H14BrNO2S
- (2S)-1-Benzylsulfonyl-2-(methoxymethyl)pyrrolidine89598-03-8C13H19NO3S
- (2-((Pyrrolidine-1-sulfonyl)methyl)phenyl)methanamine hydrochloride1423033-57-1C12H19ClN2O2S
- 1-((4-Fluorobenzyl)sulfonyl)-3-(methylsulfonyl)pyrrolidine1448060-36-3C12H16FNO4S2
- 1-((2-Chlorobenzyl)sulfonyl)-3-(methylsulfonyl)pyrrolidine1797639-46-3C12H16ClNO4S2
- Methyl 2-((1-(benzylsulfonyl)pyrrolidin-3-yl)thio)acetate2034472-01-8C14H19NO4S2
- Methyl 2-((1-((3-(trifluoromethyl)benzyl)sulfonyl)pyrrolidin-3-yl)thio)acetate2034578-80-6C15H18F3NO4S2
- 1-((3-Methylbenzyl)sulfonyl)-3-(methylsulfonyl)pyrrolidine1705043-43-1C13H19NO4S2
- 1-((2,5-Difluorobenzyl)sulfonyl)-3-(methylsulfonyl)pyrrolidine1705767-22-1C12H15F2NO4S2
- 3-(Methylsulfonyl)-1-((4-(trifluoromethyl)benzyl)sulfonyl)pyrrolidine1705043-62-4C13H16F3NO4S2
- 1-((2-Bromobenzyl)sulfonyl)pyrrolidine1286754-40-2C11H14BrNO2S
- 1-[(3-Methylphenyl)methanesulfonyl]-3-(methylsulfanyl)pyrrolidine2097902-35-5C13H19NO2S2
- 1-[(3-Chlorophenyl)methanesulfonyl]-3-(methylsulfanyl)pyrrolidine2097895-18-4C12H16ClNO2S2
- 3-(Methylsulfanyl)-1-{[4-(trifluoromethyl)phenyl]methanesulfonyl}pyrrolidine2320609-83-2C13H16F3NO2S2
- N-({2-[(Pyrrolidine-1-sulfonyl)methyl]phenyl}methyl)prop-2-enamide2361805-86-7C15H20N2O3S
- 2-(Azidomethyl)-1-phenylmethanesulfonylpyrrolidine3054617-51-2C12H16N4O2S
- 2-(Azidomethyl)-1-[(2-fluorophenyl)methanesulfonyl]pyrrolidine3054607-73-4C12H15FN4O2S
- 2-(Azidomethyl)-1-[(4-methylphenyl)methanesulfonyl]pyrrolidine3054607-65-4C13H18N4O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1cccs1)c1ccccc152 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals