Murcko scaffold
Cyclohexanecarboxamide, N-(2-phenylethyl)- scaffold
51 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 17
- Chemicals
- 51
- With full pages
- 9
Scaffold SMILES
O=C(NCCc1ccccc1)C1CCCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 51 chemicals
![2-{[4-(Methylethyl)cyclohexyl]carbonylamino}-3-phenylpropanoic acid chemical structure, C19H27NO3, CAS 491828-09-2](/s/OELFLUMRDSZNSF-UHFFFAOYSA-N.svg)
2-{[4-(Methylethyl)cyclohexyl]carbonylamino}-3-phenylpropanoic acid
CAS 491828-09-2C19H27NO3
ent-Nateglinide
CAS 105816-05-5C19H27NO3
N-(Cyclohexanecarbonyl)-2-methoxy-O,5-dimethyltyrosine
CAS 7149-84-0C19H27NO5
N-(Cyclohexanecarbonyl)-2-methoxy-O,3-dimethyltyrosine
CAS 7149-87-3C19H27NO5
2-(Cyclohexanecarbonylamino)-3-(2,4-dimethoxy-6-methylphenyl)propanoic acid
CAS 7149-89-5C19H27NO5
(1S,2R)-2-(Phenethylcarbamoyl)cyclohexane-1-carboxylic acid
CAS 1164489-38-6C16H21NO3
![N-[2-(4-Sulfamoylphenyl)ethyl]cyclohexanecarboxamide chemical structure, C15H22N2O3S, CAS 5092-65-9](/s/IPFNJTPHAHOBCA-UHFFFAOYSA-N.svg)
N-[2-(4-Sulfamoylphenyl)ethyl]cyclohexanecarboxamide
CAS 5092-65-9C15H22N2O3S
![N-[2-(3-Chlorophenyl)ethyl]cyclohexanecarboxamide chemical structure, C15H20ClNO, CAS 544432-85-1](/s/OQUZICRBFICEIY-UHFFFAOYSA-N.svg)
N-[2-(3-Chlorophenyl)ethyl]cyclohexanecarboxamide
CAS 544432-85-1C15H20ClNO
Cyclohexanecarboxamide, N-(2-phenylethyl)-
CAS 53182-00-6C15H21NO
N-(Cyclohexylcarbonyl)-D-phenylalanine
CAS 85856-40-2C16H21NO3
![2-{[(2-Phenylpropyl)amino]carbonyl}cyclohexanecarboxylic acid chemical structure, C17H23NO3, CAS 1005138-04-4](/s/INZTYXSLGLFGIE-UHFFFAOYSA-N.svg)
2-{[(2-Phenylpropyl)amino]carbonyl}cyclohexanecarboxylic acid
CAS 1005138-04-4C17H23NO3
![2-{[(2-Phenylethyl)amino]carbonyl}cyclohexanecarboxylic acid chemical structure, C16H21NO3, CAS 331987-60-1](/s/ZVGKSRYCAMAYDG-UHFFFAOYSA-N.svg)
2-{[(2-Phenylethyl)amino]carbonyl}cyclohexanecarboxylic acid
CAS 331987-60-1C16H21NO3
![Cyclohexanecarboxylic acid, 2-[[[2-(4-methoxyphenyl)ethyl]amino]carbonyl]- chemical structure, C17H23NO4, CAS 313392-85-7](/s/SBACHGGZEYMQAB-UHFFFAOYSA-N.svg)
Cyclohexanecarboxylic acid, 2-[[[2-(4-methoxyphenyl)ethyl]amino]carbonyl]-
CAS 313392-85-7C17H23NO4
N-(Cyclohexylcarbonyl)phenylalanine
CAS 103678-63-3C16H21NO3
![4-Butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]cyclohexanecarboxamide chemical structure, C21H33NO3, CAS 714261-71-9](/s/KNKJYKPIXNVBEW-UHFFFAOYSA-N.svg)
4-Butyl-N-[2-(3,4-dimethoxyphenyl)ethyl]cyclohexanecarboxamide
CAS 714261-71-9C21H33NO3
![4-Butyl-N-[2-(4-sulfamoylphenyl)ethyl]cyclohexane-1-carboxamide chemical structure, C19H30N2O3S, CAS 714262-24-5](/s/VDTCNNSUNUDGJZ-UHFFFAOYSA-N.svg)
4-Butyl-N-[2-(4-sulfamoylphenyl)ethyl]cyclohexane-1-carboxamide
CAS 714262-24-5C19H30N2O3S
N-Cyclohexanoyl dopamine
CAS 42600-76-0C15H21NO3
![N-[2-Hydroxy-2-(4-nitrophenyl)ethyl]cyclohexanecarboxamide chemical structure, C15H20N2O4, CAS 325744-02-3](/s/ITBMODOIDNVECA-UHFFFAOYSA-N.svg)
N-[2-Hydroxy-2-(4-nitrophenyl)ethyl]cyclohexanecarboxamide
CAS 325744-02-3C15H20N2O4
Nateglinide
CAS 105816-04-4C19H27NO3
N-(4-tert-Butylcyclohexane-1-carbonyl)phenylalanine
CAS 105746-46-1C20H29NO3
N-(4-Ethylcyclohexane-1-carbonyl)-D-phenylalanine
CAS 105746-45-0C18H25NO3
![D-Phenylalanine, N-[[cis-4-(1-methylethyl)cyclohexyl]carbonyl]-, methyl ester chemical structure, C20H29NO3, CAS 958230-60-9](/s/LUSNEIVFFXOKHW-UHFFFAOYSA-N.svg)
D-Phenylalanine, N-[[cis-4-(1-methylethyl)cyclohexyl]carbonyl]-, methyl ester
CAS 958230-60-9C20H29NO3
Nateglinide methyl ester
CAS 105746-47-2C20H29NO3
![[1(R)-trans]-alpha-[[[4-(1-Methylethyl)cyclohexyl]carbonyl]amino]benzenepropanamide chemical structure, C19H28N2O2, CAS 120927-39-1](/s/AUSHCEKRHXBBSE-OFLPRAFFSA-N.svg)
[1(R)-trans]-alpha-[[[4-(1-Methylethyl)cyclohexyl]carbonyl]amino]benzenepropanamide
CAS 120927-39-1C19H28N2O2
- N-(Cyclohexanecarbonyl)-L-tyrosine168980-16-3C16H21NO4
- Methyl N-{[1,3,4,5-tetrakis(acetyloxy)cyclohexyl]carbonyl}-L-phenylalaninate309964-74-7C25H31NO11
- N-Cyclohexanoyl tyramine727732-91-4C15H21NO2
- (1R,2S,5R)-N-[2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N,5-dimethyl-2-(1-methylethyl)cyclohexanecarboxamide943543-27-9C20H31NO3
- Nateglinide ethyl ester187728-85-4C21H31NO3
- (trans-4-Isopropylcyclohexane-1-carbonyl)-D-tyrosine183996-89-6C19H27NO4
- Nateglinide D51227666-13-8C19H27NO3
- N-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(methanesulfonamidomethyl)cyclohexane-1-carboxamide1203148-54-2C19H30N2O5S
- 4-(Methanesulfonamidomethyl)-N-[2-(4-sulfamoylphenyl)ethyl]cyclohexane-1-carboxamide1203198-19-9C17H27N3O5S2
- 4-(Ethylsulfonamidomethyl)-N-(2-methoxyphenethyl)cyclohexanecarboxamide1206987-09-8C19H30N2O4S
- N-[2-(3-Methoxyphenyl)ethyl]cyclohexanecarboxamide347975-52-4C16H23NO2
- N-[2-(3-Bromophenyl)ethyl]cyclohexanecarboxamide919347-66-3C15H20BrNO
- 4-Desisopropyl-4-ethyl Nateglinide-d51356011-67-0C18H25NO3
- N-(2-Hydroxy-2-(4-(methylthio)phenyl)ethyl)cyclohexanecarboxamide1448122-92-6C16H23NO2S
- 1-Amino-N-[2-[4-(aminosulfonyl)phenyl]ethyl]cyclohexanecarboxamide851307-71-6C15H23N3O3S
- N-((trans-4-(1-Hydroxy-1-methylethyl)cyclohexyl)carbonyl)-D-phenylalanine183996-82-9C19H27NO4
- N-((trans-4-((1R)-2-Hydroxy-1-methylethyl)cyclohexyl)carbonyl)-D-phenylalanine183996-84-1C19H27NO4
- N-((trans-4-((1S)-2-Hydroxy-1-methylethyl)cyclohexyl)carbonyl)-D-phenylalanine183996-83-0C19H27NO4
- N-((trans-4-((1S)-1,2-Dihydroxy-1-methylethyl)cyclohexyl)carbonyl)-D-phenylalanine347851-64-3C19H27NO5
- N-((trans-4-((1R)-1,2-Dihydroxy-1-methylethyl)cyclohexyl)carbonyl)-D-phenylalanine347851-65-4C19H27NO5
- N-((trans-4-(1-Methylethenyl)cyclohexyl)carbonyl)-D-phenylalanine183996-88-5C19H25NO3
- Methyl (4,4-difluorocyclohexane-1-carbonyl)-L-phenylalaninateC17H21F2NO3
- 4-Bromo-N-[(trans-4-{[(tert-butoxycarbonyl)amino]methyl}cyclohexyl)carbonyl]-L-phenylalanine1684429-13-7C22H31BrN2O5
- Methyl 2-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate2242582-46-1C17H21F2NO3
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(COc1ccccc1)Nc1ccccc1476 chemicals
O=C(NN=Cc1ccccc1)c1ccccc1265 chemicals
O=C(C=Cc1ccccc1)Nc1ccccc1175 chemicals
O=C(CCc1ccccc1)Nc1ccccc1153 chemicals
O=C(NCCc1ccccc1)c1ccccc1147 chemicals
S=C(NCc1ccccc1)Nc1ccccc1127 chemicals
O=C(CCNc1ccccc1)c1ccccc1120 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccccc196 chemicals
O=S(=O)(NCCc1ccccc1)c1ccccc183 chemicals
O=C(CNc1ccccc1)Nc1ccccc183 chemicals
O=C(CSc1ccccc1)Nc1ccccc177 chemicals
c1ccc(CCNCc2ccccc2)cc173 chemicals