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Murcko scaffold

Ring system with 5 rings and 29 atoms

6 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
29
Chemicals
6
With full pages
3
Scaffold SMILES

O=c1cc(-c2ccccc2)c2cc(C(c3ccccc3)c3cnc[nH]3)ccc2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1cc(-c2ccccc2)c2cc(C(c3ccccc3)c3cnc[nH]3)ccc2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 6 of 6 chemicals

RefChem:930522 chemical structure, C27H22Cl2N4O, CAS 192185-68-5
RefChem:930522
CAS 192185-68-5C27H22Cl2N4O
Tipifarnib chemical structure, C27H22Cl2N4O, CAS 192185-72-1
Tipifarnib
CAS 192185-72-1C27H22Cl2N4O
6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one chemical structure, C29H22ClN3O2, CAS 439153-64-7
6-((4-Chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methylquinolin-2(1H)-one
CAS 439153-64-7C29H22ClN3O2
Tipifarnib S enantiomer chemical structure, C27H22Cl2N4O, CAS 192185-71-0
Tipifarnib S enantiomer
CAS 192185-71-0C27H22Cl2N4O
Cp-609754 chemical structure, C29H22ClN3O2, CAS 1190094-64-4
Cp-609754
CAS 1190094-64-4C29H22ClN3O2
2(1H)-Quinolinone, 6-((4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methyl- chemical structure, C33H28ClN3O8
2(1H)-Quinolinone, 6-((4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-ethynylphenyl)-1-methyl-
C33H28ClN3O8