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Murcko scaffold

Ring system with 4 rings and 20 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
8
With full pages
3
Scaffold SMILES

O=c1c2[nH]c3ccsc3c2cnn1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c2[nH]c3ccsc3c2cnn1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

6-(2-Fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno(2',3':4,5)pyrrolo(2,3-d)pyridazin-5-one chemical structure, C17H14FN3OS, CAS 842112-70-3
6-(2-Fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno(2',3':4,5)pyrrolo(2,3-d)pyridazin-5-one
CAS 842112-70-3C17H14FN3OS
6-[(3-Methoxyphenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone chemical structure, C18H17N3O3S2, CAS 1221186-52-2
6-[(3-Methoxyphenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone
CAS 1221186-52-2C18H17N3O3S2
6-((3-Aminophenyl)methyl)-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno(2',3':4,5)pyrrolo(2,3-d)pyridazin-5-one chemical structure, C17H16N4O2S2, CAS 1221186-53-3
6-((3-Aminophenyl)methyl)-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno(2',3':4,5)pyrrolo(2,3-d)pyridazin-5-one
CAS 1221186-53-3C17H16N4O2S2
2-Bromo-4,6-dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-5H-thieno[2',3':4,5]pyrrolo[2,3-D]pyridazin-5-one chemical structure, C17H14BrN3O2S, CAS 1222839-26-0
2-Bromo-4,6-dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-5H-thieno[2',3':4,5]pyrrolo[2,3-D]pyridazin-5-one
CAS 1222839-26-0C17H14BrN3O2S
6-(3-Hydroxybenzyl)-4-methyl-2-(methylthio)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one chemical structure, C17H15N3O2S2, CAS 1222851-21-9
6-(3-Hydroxybenzyl)-4-methyl-2-(methylthio)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one
CAS 1222851-21-9C17H15N3O2S2
6-(3-Hydroxybenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one chemical structure, C17H15N3O3S2, CAS 1222535-34-3
6-(3-Hydroxybenzyl)-4-methyl-2-(methylsulfinyl)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one
CAS 1222535-34-3C17H15N3O3S2
6-(3-Aminobenzyl)-4-methyl-2-(methylthio)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one chemical structure, C17H16N4OS2, CAS 1667722-04-4
6-(3-Aminobenzyl)-4-methyl-2-(methylthio)-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one
CAS 1667722-04-4C17H16N4OS2
6-(3-Aminobenzyl)-2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one chemical structure, C16H13BrN4OS, CAS 1667722-03-3
6-(3-Aminobenzyl)-2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one
CAS 1667722-03-3C16H13BrN4OS