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Murcko scaffold

Ring system with 3 rings and 18 atoms

30 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
30
With full pages
3
Scaffold SMILES

O=C(Nc1[nH]nc2c1CS(=O)C2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1[nH]nc2c1CS(=O)C2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-fluorobenzamide chemical structure, C16H18FN3O2S, CAS 958587-25-2
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-fluorobenzamide
CAS 958587-25-2C16H18FN3O2S
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3-fluorobenzamide chemical structure, C16H18FN3O2S, CAS 1007192-27-9
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3-fluorobenzamide
CAS 1007192-27-9C16H18FN3O2S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-fluorobenzamide chemical structure, C16H18FN3O2S, CAS 1020452-79-2
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-fluorobenzamide
CAS 1020452-79-2C16H18FN3O2S
N-(2-tert-Butyl-5-oxo-2,4,5,6-tetrahydro-5lambda~4~-thieno[3,4-c]pyrazol-3-yl)-3-methoxybenzamide chemical structure, C17H21N3O3S, CAS 6231-51-2
N-(2-tert-Butyl-5-oxo-2,4,5,6-tetrahydro-5lambda~4~-thieno[3,4-c]pyrazol-3-yl)-3-methoxybenzamide
CAS 6231-51-2C17H21N3O3S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,4-diethoxybenzamide chemical structure, C20H27N3O4S, CAS 1009666-71-0
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,4-diethoxybenzamide
CAS 1009666-71-0C20H27N3O4S
2-Bromo-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C16H18BrN3O2S, CAS 958587-44-5
2-Bromo-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958587-44-5C16H18BrN3O2S
3-Bromo-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C16H18BrN3O2S, CAS 958587-53-6
3-Bromo-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958587-53-6C16H18BrN3O2S
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2,6-difluorobenzamide chemical structure, C16H17F2N3O2S, CAS 1007193-48-7
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2,6-difluorobenzamide
CAS 1007193-48-7C16H17F2N3O2S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2,4-dimethoxybenzamide chemical structure, C18H23N3O4S, CAS 958587-37-6
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2,4-dimethoxybenzamide
CAS 958587-37-6C18H23N3O4S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,4,5-triethoxybenzamide chemical structure, C22H31N3O5S, CAS 958983-87-4
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,4,5-triethoxybenzamide
CAS 958983-87-4C22H31N3O5S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-ethoxybenzamide chemical structure, C18H23N3O3S, CAS 1007476-29-0
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-ethoxybenzamide
CAS 1007476-29-0C18H23N3O3S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methylbenzamide chemical structure, C17H21N3O2S, CAS 1008454-41-8
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methylbenzamide
CAS 1008454-41-8C17H21N3O2S
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3-chlorobenzamide chemical structure, C16H18ClN3O2S, CAS 1008920-70-4
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3-chlorobenzamide
CAS 1008920-70-4C16H18ClN3O2S
4-Bromo-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C16H18BrN3O2S, CAS 958708-80-0
4-Bromo-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958708-80-0C16H18BrN3O2S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-iodobenzamide chemical structure, C16H18IN3O2S, CAS 1007192-99-5
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-iodobenzamide
CAS 1007192-99-5C16H18IN3O2S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-nitrobenzamide chemical structure, C16H18N4O4S, CAS 958703-02-1
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-nitrobenzamide
CAS 958703-02-1C16H18N4O4S
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3-nitrobenzamide chemical structure, C16H18N4O4S, CAS 1007194-30-0
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3-nitrobenzamide
CAS 1007194-30-0C16H18N4O4S
4-Butoxy-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C20H27N3O3S, CAS 958703-62-3
4-Butoxy-N-(2-(tert-butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)benzamide
CAS 958703-62-3C20H27N3O3S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2,4-dichlorobenzamide chemical structure, C16H17Cl2N3O2S, CAS 1007550-90-4
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2,4-dichlorobenzamide
CAS 1007550-90-4C16H17Cl2N3O2S
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2,5-dichlorobenzamide chemical structure, C16H17Cl2N3O2S, CAS 1008656-14-1
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2,5-dichlorobenzamide
CAS 1008656-14-1C16H17Cl2N3O2S
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-chloro-6-fluorobenzamide chemical structure, C16H17ClFN3O2S, CAS 1007193-87-4
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-chloro-6-fluorobenzamide
CAS 1007193-87-4C16H17ClFN3O2S
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-5-chloro-2-nitrobenzamide chemical structure, C16H17ClN4O4S, CAS 1009506-21-1
N-(2-(tert-Butyl)-5-oxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-5-chloro-2-nitrobenzamide
CAS 1009506-21-1C16H17ClN4O4S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methyl-3-nitrobenzamide chemical structure, C17H20N4O4S, CAS 1007195-15-4
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methyl-3-nitrobenzamide
CAS 1007195-15-4C17H20N4O4S
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,5-dimethoxybenzamide chemical structure, C18H23N3O4S, CAS 1008453-32-4
N-(2-tert-Butyl-5-oxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,5-dimethoxybenzamide
CAS 1008453-32-4C18H23N3O4S