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Murcko scaffold

Ring system with 3 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
18
With full pages
11
Scaffold SMILES

O=C(Nc1[nH]nc2c1CS(=O)(=O)C2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1[nH]nc2c1CS(=O)(=O)C2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methylbenzamide chemical structure, C17H21N3O3S, CAS 449783-68-0
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methylbenzamide
CAS 449783-68-0C17H21N3O3S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-chloro-3-nitrobenzamide chemical structure, C16H17ClN4O5S, CAS 449784-39-8
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-chloro-3-nitrobenzamide
CAS 449784-39-8C16H17ClN4O5S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)benzamide chemical structure, C16H19N3O3S, CAS 681265-19-0
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)benzamide
CAS 681265-19-0C16H19N3O3S
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-fluorobenzamide chemical structure, C16H18FN3O3S, CAS 449783-88-4
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-fluorobenzamide
CAS 449783-88-4C16H18FN3O3S
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethoxybenzamide chemical structure, C18H23N3O5S, CAS 449784-47-8
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethoxybenzamide
CAS 449784-47-8C18H23N3O5S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methyl-3-nitrobenzamide chemical structure, C17H20N4O5S, CAS 449784-33-2
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-methyl-3-nitrobenzamide
CAS 449784-33-2C17H20N4O5S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2,3-dimethoxybenzamide chemical structure, C18H23N3O5S, CAS 449784-51-4
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2,3-dimethoxybenzamide
CAS 449784-51-4C18H23N3O5S
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-5-chloro-2-nitrobenzamide chemical structure, C16H17ClN4O5S, CAS 449784-29-6
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-5-chloro-2-nitrobenzamide
CAS 449784-29-6C16H17ClN4O5S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-methyl-3-nitrobenzamide chemical structure, C17H20N4O5S, CAS 449784-35-4
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-methyl-3-nitrobenzamide
CAS 449784-35-4C17H20N4O5S
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-(trifluoromethyl)benzamide chemical structure, C17H18F3N3O3S, CAS 449784-11-6
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-(trifluoromethyl)benzamide
CAS 449784-11-6C17H18F3N3O3S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3-methoxybenzamide chemical structure, C17H21N3O4S, CAS 449783-97-5
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3-methoxybenzamide
CAS 449783-97-5C17H21N3O4S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-ethoxybenzamide chemical structure, C18H23N3O4S, CAS 449784-03-6
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-ethoxybenzamide
CAS 449784-03-6C18H23N3O4S
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-nitrobenzamide chemical structure, C16H18N4O5S, CAS 449784-05-8
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-nitrobenzamide
CAS 449784-05-8C16H18N4O5S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-chloro-5-nitrobenzamide chemical structure, C16H17ClN4O5S, CAS 449784-31-0
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-2-chloro-5-nitrobenzamide
CAS 449784-31-0C16H17ClN4O5S
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-chloro-6-fluorobenzamide chemical structure, C16H17ClFN3O3S, CAS 449784-37-6
N-(2-(tert-Butyl)-5,5-dioxido-4,6-dihydro-2H-thieno[3,4-c]pyrazol-3-yl)-2-chloro-6-fluorobenzamide
CAS 449784-37-6C16H17ClFN3O3S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,4-difluorobenzamide chemical structure, C16H17F2N3O3S, CAS 893923-65-4
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-3,4-difluorobenzamide
CAS 893923-65-4C16H17F2N3O3S
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-(trifluoromethyl)benzamide chemical structure, C17H18F3N3O3S, CAS 893923-72-3
N-(2-tert-Butyl-5,5-dioxo-4,6-dihydrothieno[3,4-c]pyrazol-3-yl)-4-(trifluoromethyl)benzamide
CAS 893923-72-3C17H18F3N3O3S
N-{2-tert-Butyl-5,5-dioxo-2H,4H,6H-5lambda6-thieno[3,4-c]pyrazol-3-yl}-2-difluoromethanesulfonylbenzamide chemical structure, C17H19F2N3O5S2, CAS 893925-97-8
N-{2-tert-Butyl-5,5-dioxo-2H,4H,6H-5lambda6-thieno[3,4-c]pyrazol-3-yl}-2-difluoromethanesulfonylbenzamide
CAS 893925-97-8C17H19F2N3O5S2