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Murcko scaffold

Ring system with 3 rings and 17 atoms

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
24
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)c1csc2c1CCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1csc2c1CCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

2-Amino-N-(4-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C15H16N2O2S, CAS 321529-87-7
2-Amino-N-(4-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 321529-87-7C15H16N2O2S
2-Amino-N-(2-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C15H16N2OS, CAS 126718-66-9
2-Amino-N-(2-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 126718-66-9C15H16N2OS
2-Amino-N-(4-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C15H16N2OS, CAS 329066-87-7
2-Amino-N-(4-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 329066-87-7C15H16N2OS
2-Amino-N-(4-chlorophenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C14H13ClN2OS, CAS 329066-94-6
2-Amino-N-(4-chlorophenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 329066-94-6C14H13ClN2OS
2-Acetamido-N-(2-chlorophenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C16H15ClN2O2S, CAS 329067-01-8
2-Acetamido-N-(2-chlorophenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 329067-01-8C16H15ClN2O2S
N-(2-Chlorophenyl)-2-(propanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C17H17ClN2O2S, CAS 329067-02-9
N-(2-Chlorophenyl)-2-(propanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 329067-02-9C17H17ClN2O2S
2-Amino-N-(2-ethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C16H18N2O2S, CAS 329068-87-3
2-Amino-N-(2-ethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 329068-87-3C16H18N2O2S
2-(Butanoylamino)-N-phenyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H20N2O2S, CAS 312946-59-1
2-(Butanoylamino)-N-phenyl-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 312946-59-1C18H20N2O2S
2-Amino-N-(2-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C15H16N2O2S, CAS 330188-63-1
2-Amino-N-(2-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 330188-63-1C15H16N2O2S
N-(2,4-Dimethylphenyl)-2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H17F3N2O2S, CAS 329068-61-3
N-(2,4-Dimethylphenyl)-2-[(trifluoroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 329068-61-3C18H17F3N2O2S
2-(2,2-Dimethylpropanoylamino)-N-(3-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C20H24N2O2S, CAS 352339-96-9
2-(2,2-Dimethylpropanoylamino)-N-(3-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 352339-96-9C20H24N2O2S
2-(2,2-Dimethylpropanoylamino)-N-(4-ethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C21H26N2O3S, CAS 329067-14-3
2-(2,2-Dimethylpropanoylamino)-N-(4-ethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 329067-14-3C21H26N2O3S
N-(4-Bromophenyl)-2-(2-methylpropanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C18H19BrN2O2S, CAS 333358-84-2
N-(4-Bromophenyl)-2-(2-methylpropanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 333358-84-2C18H19BrN2O2S
2-Amino-5,6-dihydro-N-phenyl-4H-cyclopenta(b)thiophene-3-carboxamide chemical structure, C14H14N2OS, CAS 321529-89-9
2-Amino-5,6-dihydro-N-phenyl-4H-cyclopenta(b)thiophene-3-carboxamide
CAS 321529-89-9C14H14N2OS
N-(4-Methoxyphenyl)-2-[(trichloroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C17H15Cl3N2O3S, CAS 397849-15-9
N-(4-Methoxyphenyl)-2-[(trichloroacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 397849-15-9C17H15Cl3N2O3S
2-Acetamido-N-(3-chloro-4-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C17H17ClN2O3S, CAS 681835-44-9
2-Acetamido-N-(3-chloro-4-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 681835-44-9C17H17ClN2O3S
2-Amino-N-(2,5-dimethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C16H18N2O3S, CAS 433245-33-1
2-Amino-N-(2,5-dimethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 433245-33-1C16H18N2O3S
N-(2,4-Dimethoxyphenyl)-2-[[2-(2-methylpropylamino)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C22H29N3O4S, CAS 524688-28-6
N-(2,4-Dimethoxyphenyl)-2-[[2-(2-methylpropylamino)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 524688-28-6C22H29N3O4S
4-({3-[(2-Methylphenyl)carbamoyl]-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl}amino)-4-oxobutanoic acid chemical structure, C19H20N2O4S, CAS 397857-93-1
4-({3-[(2-Methylphenyl)carbamoyl]-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl}amino)-4-oxobutanoic acid
CAS 397857-93-1C19H20N2O4S
2-Amino-N-(2,4-dimethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C16H18N2O3S, CAS 777878-99-6
2-Amino-N-(2,4-dimethoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 777878-99-6C16H18N2O3S
2-Amino-N-[3-(trifluoromethyl)phenyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C15H13F3N2OS, CAS 669740-00-5
2-Amino-N-[3-(trifluoromethyl)phenyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 669740-00-5C15H13F3N2OS
2-Amino-N-(3,4-dichlorophenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C14H12Cl2N2OS, CAS 725705-43-1
2-Amino-N-(3,4-dichlorophenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 725705-43-1C14H12Cl2N2OS
2-Amino-N-(3-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C15H16N2O2S, CAS 727656-12-4
2-Amino-N-(3-methoxyphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 727656-12-4C15H16N2O2S
2-Amino-N-(3-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide chemical structure, C15H16N2OS, CAS 330188-62-0
2-Amino-N-(3-methylphenyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
CAS 330188-62-0C15H16N2OS