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Murcko scaffold

Ring system with 4 rings and 27 atoms

47 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
47
With full pages
3
Scaffold SMILES

O=C(Nc1sc2c(c1C(=O)Nc1ccccc1)CCCC2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1sc2c(c1C(=O)Nc1ccccc1)CCCC2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

N-(2,4-Dimethoxyphenyl)-2-[(4-methylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C25H26N2O4S, CAS 433246-06-1
N-(2,4-Dimethoxyphenyl)-2-[(4-methylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433246-06-1C25H26N2O4S
2-[(4-Chlorobenzoyl)amino]-N-(2,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H23ClN2O4S, CAS 433701-25-8
2-[(4-Chlorobenzoyl)amino]-N-(2,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433701-25-8C24H23ClN2O4S
Ethyl 4-[({2-[(4-fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothien-3-yl}carbonyl)amino]benzoate chemical structure, C25H23FN2O4S, CAS 499198-29-7
Ethyl 4-[({2-[(4-fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothien-3-yl}carbonyl)amino]benzoate
CAS 499198-29-7C25H23FN2O4S
2-[(2-Chlorobenzoyl)amino]-N-(2,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H23ClN2O4S, CAS 433251-59-3
2-[(2-Chlorobenzoyl)amino]-N-(2,4-dimethoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433251-59-3C24H23ClN2O4S
N-(2,5-Dimethoxyphenyl)-2-[(2-fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H23FN2O4S, CAS 433249-20-8
N-(2,5-Dimethoxyphenyl)-2-[(2-fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433249-20-8C24H23FN2O4S
N-(2,4-Dimethoxyphenyl)-2-[(2-fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H23FN2O4S, CAS 433249-81-1
N-(2,4-Dimethoxyphenyl)-2-[(2-fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433249-81-1C24H23FN2O4S
2-[(2-Chlorobenzoyl)amino]-N-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H19ClN2O2S, CAS 328540-66-5
2-[(2-Chlorobenzoyl)amino]-N-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 328540-66-5C22H19ClN2O2S
N-(2-Methoxyphenyl)-2-[(2-methylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O3S, CAS 352226-62-1
N-(2-Methoxyphenyl)-2-[(2-methylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 352226-62-1C24H24N2O3S
N-(3-Methoxyphenyl)-2-[(4-methylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O3S, CAS 663217-70-7
N-(3-Methoxyphenyl)-2-[(4-methylbenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 663217-70-7C24H24N2O3S
2-[(3-Methoxybenzoyl)amino]-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O4S, CAS 433702-88-6
2-[(3-Methoxybenzoyl)amino]-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 433702-88-6C24H24N2O4S
N-(4-Methoxyphenyl)-2-[(4-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H21N3O5S, CAS 329066-92-4
N-(4-Methoxyphenyl)-2-[(4-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 329066-92-4C23H21N3O5S
N-(2-Methoxyphenyl)-2-[(4-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H21N3O5S, CAS 418792-71-9
N-(2-Methoxyphenyl)-2-[(4-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 418792-71-9C23H21N3O5S
N-(3-Methylphenyl)-2-[(4-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H21N3O4S, CAS 418793-53-0
N-(3-Methylphenyl)-2-[(4-nitrobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 418793-53-0C23H21N3O4S
2-Benzamido-N-(3-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H22N2O2S, CAS 5581-87-3
2-Benzamido-N-(3-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 5581-87-3C23H22N2O2S
N-(4-Acetylphenyl)-2-benzamido-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H22N2O3S, CAS 6868-96-8
N-(4-Acetylphenyl)-2-benzamido-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 6868-96-8C24H22N2O3S
2-[(2-Chlorobenzoyl)amino]-N-(4-chlorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H18Cl2N2O2S, CAS 329067-20-1
2-[(2-Chlorobenzoyl)amino]-N-(4-chlorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 329067-20-1C22H18Cl2N2O2S
2-[(4-Bromobenzoyl)amino]-N-(4-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H21BrN2O2S, CAS 312946-65-9
2-[(4-Bromobenzoyl)amino]-N-(4-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 312946-65-9C23H21BrN2O2S
2-[(4-Bromobenzoyl)amino]-N-(4-chlorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H18BrClN2O2S, CAS 312584-71-7
2-[(4-Bromobenzoyl)amino]-N-(4-chlorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 312584-71-7C22H18BrClN2O2S
N-(3-Bromophenyl)-2-[(3-chlorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C22H18BrClN2O2S, CAS 333358-85-3
N-(3-Bromophenyl)-2-[(3-chlorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 333358-85-3C22H18BrClN2O2S
2-[(4-Methylbenzoyl)amino]-N-(4-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H24N2O2S, CAS 333359-01-6
2-[(4-Methylbenzoyl)amino]-N-(4-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 333359-01-6C24H24N2O2S
2-[(3-Chlorobenzoyl)amino]-N-(2-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H21ClN2O2S, CAS 326610-98-4
2-[(3-Chlorobenzoyl)amino]-N-(2-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 326610-98-4C23H21ClN2O2S
2-Benzamido-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H22N2O3S, CAS 328278-79-1
2-Benzamido-N-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 328278-79-1C23H22N2O3S
2-[(2-Chlorobenzoyl)amino]-N-(2-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H21ClN2O3S, CAS 304451-82-9
2-[(2-Chlorobenzoyl)amino]-N-(2-methoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 304451-82-9C23H21ClN2O3S
2-[(2-Chlorobenzoyl)amino]-N-(4-ethoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C24H23ClN2O3S, CAS 330188-71-1
2-[(2-Chlorobenzoyl)amino]-N-(4-ethoxyphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 330188-71-1C24H23ClN2O3S