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Murcko scaffold

Ring system with 5 rings and 35 atoms

13 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
35
Chemicals
13
With full pages
7
Scaffold SMILES

O=C1C(=O)N(Cc2cccnc2)C(c2ccccc2)C1=Cc1ccc(OCc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(Cc2cccnc2)C(c2ccccc2)C1=Cc1ccc(OCc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

4-[4-(Benzyloxy)-3-methylbenzoyl]-3-hydroxy-5-phenyl-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C31H26N2O4
4-[4-(Benzyloxy)-3-methylbenzoyl]-3-hydroxy-5-phenyl-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C31H26N2O4
1,5-Dihydro-3-hydroxy-4-[2-methyl-4-(phenylmethoxy)benzoyl]-5-(3-nitrophenyl)-1-(3-pyridinylmethyl)-2H-pyrrol-2-one chemical structure, C31H25N3O6
1,5-Dihydro-3-hydroxy-4-[2-methyl-4-(phenylmethoxy)benzoyl]-5-(3-nitrophenyl)-1-(3-pyridinylmethyl)-2H-pyrrol-2-one
C31H25N3O6
4-[4-(Benzyloxy)benzoyl]-3-hydroxy-5-phenyl-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C30H24N2O4
4-[4-(Benzyloxy)benzoyl]-3-hydroxy-5-phenyl-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C30H24N2O4
4-{[4-(Benzyloxy)-3-methylphenyl]carbonyl}-3-hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C31H26N2O4, CAS 497242-75-8
4-{[4-(Benzyloxy)-3-methylphenyl]carbonyl}-3-hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 497242-75-8C31H26N2O4
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3-ethoxy-4-hydroxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C33H30N2O6, CAS 488096-74-8
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3-ethoxy-4-hydroxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 488096-74-8C33H30N2O6
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(4-ethoxy-3-methoxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C34H32N2O6, CAS 488133-00-2
4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(4-ethoxy-3-methoxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 488133-00-2C34H32N2O6
4-(4-(Benzyloxy)benzoyl)-3-hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C30H24N2O4, CAS 844651-56-5
4-(4-(Benzyloxy)benzoyl)-3-hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one
CAS 844651-56-5C30H24N2O4
4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-5-(4-hydroxyphenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C31H26N2O5, CAS 488840-67-1
4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-5-(4-hydroxyphenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 488840-67-1C31H26N2O5
4-[4-(Benzyloxy)-2-methylbenzoyl]-5-(3,4-dimethoxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C33H30N2O6, CAS 497243-43-3
4-[4-(Benzyloxy)-2-methylbenzoyl]-5-(3,4-dimethoxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 497243-43-3C33H30N2O6
4-[4-(Benzyloxy)-2-methylbenzoyl]-3-hydroxy-5-(3-nitrophenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C31H25N3O6, CAS 488862-01-7
4-[4-(Benzyloxy)-2-methylbenzoyl]-3-hydroxy-5-(3-nitrophenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 488862-01-7C31H25N3O6
4-[4-(Benzyloxy)-2-methylbenzoyl]-5-(4-chlorophenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C31H25ClN2O4, CAS 497247-66-2
4-[4-(Benzyloxy)-2-methylbenzoyl]-5-(4-chlorophenyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 497247-66-2C31H25ClN2O4
4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C32H28N2O6, CAS 500274-51-1
4-(4-(Benzyloxy)-2-methylbenzoyl)-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 500274-51-1C32H28N2O6
(4E)-4-[Hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-5-(4-methylphenyl)-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C32H28N2O4, CAS 499116-00-6
(4E)-4-[Hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-5-(4-methylphenyl)-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 499116-00-6C32H28N2O4