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Murcko scaffold

2H-Naphth(1,8-cd)isothiazole 1,1-dioxide scaffold

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
18
With full pages
11
Scaffold SMILES

O=S1(=O)Nc2cccc3cccc1c23

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2H-Naphth(1,8-cd)isothiazole 1,1-dioxide page
Murcko scaffold O=S1(=O)Nc2cccc3cccc1c23

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2H-Naphth(1,8-cd)isothiazole-3,5-disulfonic acid, 1,1-dioxide chemical structure, C10H7NO8S3, CAS 82-65-5
2H-Naphth(1,8-cd)isothiazole-3,5-disulfonic acid, 1,1-dioxide
CAS 82-65-5C10H7NO8S3
2H-Naphth(1,8-cd)isothiazole 1,1-dioxide chemical structure, C10H7NO2S, CAS 603-72-5
2H-Naphth(1,8-cd)isothiazole 1,1-dioxide
CAS 603-72-5C10H7NO2S
5-(1,1-Dioxido-2H-naphtho[1,8-CD]isothiazol-2-yl)pentanenitrile chemical structure, C15H14N2O2S, CAS 681835-60-9
5-(1,1-Dioxido-2H-naphtho[1,8-CD]isothiazol-2-yl)pentanenitrile
CAS 681835-60-9C15H14N2O2S
2-Propyl-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide chemical structure, C13H13NO2S, CAS 445411-09-6
2-Propyl-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide
CAS 445411-09-6C13H13NO2S
3-Methylsulfonyl-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene 2,2-dioxide chemical structure, C11H9NO4S2, CAS 725717-74-8
3-Methylsulfonyl-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaene 2,2-dioxide
CAS 725717-74-8C11H9NO4S2
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-prop-2-enylacetamide chemical structure, C15H14N2O3S, CAS 565180-71-4
2-(2,2-Dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)-N-prop-2-enylacetamide
CAS 565180-71-4C15H14N2O3S
tert-Butyl 2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetate chemical structure, C16H17NO4S, CAS 571920-74-6
tert-Butyl 2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetate
CAS 571920-74-6C16H17NO4S
2-(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)acetohydrazide chemical structure, C12H11N3O3S, CAS 790271-29-3
2-(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)acetohydrazide
CAS 790271-29-3C12H11N3O3S
N-Carbamoyl-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide chemical structure, C13H11N3O4S, CAS 852131-51-2
N-Carbamoyl-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide
CAS 852131-51-2C13H11N3O4S
2-(4-Chlorobutyl)-1lambda6-naphtho[1,8-CD]isothiazole-1,1(2H)-dione chemical structure, C14H14ClNO2S, CAS 127625-85-8
2-(4-Chlorobutyl)-1lambda6-naphtho[1,8-CD]isothiazole-1,1(2H)-dione
CAS 127625-85-8C14H14ClNO2S
N-Butan-2-yl-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide chemical structure, C16H18N2O3S, CAS 565201-02-7
N-Butan-2-yl-2-(2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.04,12]dodeca-1(11),4,6,8(12),9-pentaen-3-yl)acetamide
CAS 565201-02-7C16H18N2O3S
(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)acetic acid chemical structure, C12H9NO4S, CAS 857041-85-1
(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)acetic acid
CAS 857041-85-1C12H9NO4S
2-(2-Bromoethyl)-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide chemical structure, C12H10BrNO2S, CAS 131729-17-4
2-(2-Bromoethyl)-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide
CAS 131729-17-4C12H10BrNO2S
3-(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)propanoic acid chemical structure, C13H11NO4S, CAS 848369-67-5
3-(1,1-Dioxido-2H-naphtho[1,8-cd]isothiazol-2-yl)propanoic acid
CAS 848369-67-5C13H11NO4S
2H-Naphth[1,8-cd]isothiazole-2-acetamide, N-(1,1-dimethylethyl)-I+/--methyl-, 1,1-dioxide chemical structure, C17H20N2O3S, CAS 862677-83-6
2H-Naphth[1,8-cd]isothiazole-2-acetamide, N-(1,1-dimethylethyl)-I+/--methyl-, 1,1-dioxide
CAS 862677-83-6C17H20N2O3S
N-(1-Cyano-1,2-dimethylpropyl)-2-{2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.0,4,12]dodeca-1(11),4(12),5,7,9-pentaen-3-yl}acetamide chemical structure, C18H19N3O3S, CAS 872110-27-5
N-(1-Cyano-1,2-dimethylpropyl)-2-{2,2-dioxo-2lambda6-thia-3-azatricyclo[6.3.1.0,4,12]dodeca-1(11),4(12),5,7,9-pentaen-3-yl}acetamide
CAS 872110-27-5C18H19N3O3S
6-Bromo-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide chemical structure, C10H6BrNO2S, CAS 198472-28-5
6-Bromo-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide
CAS 198472-28-5C10H6BrNO2S
2H-Naphth[1,8-cd]isothiazole-2-propanenitrile, 1,1-dioxide chemical structure, C13H10N2O2S, CAS 4825-67-6
2H-Naphth[1,8-cd]isothiazole-2-propanenitrile, 1,1-dioxide
CAS 4825-67-6C13H10N2O2S