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Murcko scaffold

Ring system with 4 rings and 23 atoms

30 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
30
With full pages
2
Scaffold SMILES

O=C(c1cc(-c2ccccc2)nc2ccccc12)N1CCC=N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc(-c2ccccc2)nc2ccccc12)N1CCC=N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[6-methyl-2-(4-propan-2-ylphenyl)quinolin-4-yl]methanone chemical structure, C25H23F4N3O2, CAS 438236-44-3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[6-methyl-2-(4-propan-2-ylphenyl)quinolin-4-yl]methanone
CAS 438236-44-3C25H23F4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-propan-2-yloxyphenyl)quinolin-4-yl]methanone chemical structure, C24H21F4N3O3, CAS 438237-35-5
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-propan-2-yloxyphenyl)quinolin-4-yl]methanone
CAS 438237-35-5C24H21F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2,4-dichlorophenyl)quinolin-4-yl]methanone chemical structure, C21H13Cl2F4N3O2, CAS 438235-46-2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2,4-dichlorophenyl)quinolin-4-yl]methanone
CAS 438235-46-2C21H13Cl2F4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-(2-phenylquinolin-4-yl)methanone chemical structure, C21H15F4N3O2, CAS 438233-16-0
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-(2-phenylquinolin-4-yl)methanone
CAS 438233-16-0C21H15F4N3O2
1-(2-Phenylquinoline-4-carbonyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-ol chemical structure, C20H14F3N3O2, CAS 305854-49-3
1-(2-Phenylquinoline-4-carbonyl)-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-ol
CAS 305854-49-3C20H14F3N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-chlorophenyl)quinolin-4-yl]methanone chemical structure, C21H14ClF4N3O2, CAS 438232-94-1
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-chlorophenyl)quinolin-4-yl]methanone
CAS 438232-94-1C21H14ClF4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-propan-2-yloxyphenyl)quinolin-4-yl]methanone chemical structure, C24H21F4N3O3, CAS 438236-55-6
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-propan-2-yloxyphenyl)quinolin-4-yl]methanone
CAS 438236-55-6C24H21F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-ethoxyphenyl)quinolin-4-yl]methanone chemical structure, C23H19F4N3O3, CAS 438233-01-3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-ethoxyphenyl)quinolin-4-yl]methanone
CAS 438233-01-3C23H19F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-ethoxyphenyl)quinolin-4-yl]methanone chemical structure, C23H19F4N3O3, CAS 438235-22-4
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-ethoxyphenyl)quinolin-4-yl]methanone
CAS 438235-22-4C23H19F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-propan-2-yloxyphenyl)quinolin-4-yl]methanone chemical structure, C24H21F4N3O3, CAS 438235-02-0
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-propan-2-yloxyphenyl)quinolin-4-yl]methanone
CAS 438235-02-0C24H21F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-methoxyphenyl)quinolin-4-yl]methanone chemical structure, C22H17F4N3O3, CAS 438234-92-5
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-methoxyphenyl)quinolin-4-yl]methanone
CAS 438234-92-5C22H17F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-bromophenyl)quinolin-4-yl]methanone chemical structure, C21H14BrF4N3O2, CAS 438233-62-6
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-bromophenyl)quinolin-4-yl]methanone
CAS 438233-62-6C21H14BrF4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-methoxyphenyl)quinolin-4-yl]methanone chemical structure, C22H17F4N3O3, CAS 438237-32-2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-methoxyphenyl)quinolin-4-yl]methanone
CAS 438237-32-2C22H17F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-[3-(2-methylpropoxy)phenyl]quinolin-4-yl]methanone chemical structure, C25H23F4N3O3, CAS 438236-03-4
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-[3-(2-methylpropoxy)phenyl]quinolin-4-yl]methanone
CAS 438236-03-4C25H23F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-ethoxyphenyl)quinolin-4-yl]methanone chemical structure, C23H19F4N3O3, CAS 438234-63-0
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-ethoxyphenyl)quinolin-4-yl]methanone
CAS 438234-63-0C23H19F4N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2,4-dimethoxyphenyl)quinolin-4-yl]methanone chemical structure, C23H19F4N3O4, CAS 438232-52-1
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2,4-dimethoxyphenyl)quinolin-4-yl]methanone
CAS 438232-52-1C23H19F4N3O4
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3,4-dimethoxyphenyl)quinolin-4-yl]methanone chemical structure, C23H19F4N3O4, CAS 438237-31-1
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3,4-dimethoxyphenyl)quinolin-4-yl]methanone
CAS 438237-31-1C23H19F4N3O4
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-propoxyphenyl)quinolin-4-yl]methanone chemical structure, C24H21F4N3O3, CAS 438234-85-6
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(3-propoxyphenyl)quinolin-4-yl]methanone
CAS 438234-85-6C24H21F4N3O3
[5-(Difluoromethyl)-5-hydroxy-3-methyl-4H-pyrazol-1-yl]-[2-(3-ethoxyphenyl)quinolin-4-yl]methanone chemical structure, C23H21F2N3O3, CAS 438227-10-2
[5-(Difluoromethyl)-5-hydroxy-3-methyl-4H-pyrazol-1-yl]-[2-(3-ethoxyphenyl)quinolin-4-yl]methanone
CAS 438227-10-2C23H21F2N3O3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-propan-2-ylphenyl)-4-quinolinyl]methanone chemical structure, C24H21F4N3O2, CAS 438236-74-9
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-propan-2-ylphenyl)-4-quinolinyl]methanone
CAS 438236-74-9C24H21F4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[6-bromo-2-(4-tert-butylphenyl)quinolin-4-yl]methanone chemical structure, C25H22BrF4N3O2, CAS 438232-55-4
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[6-bromo-2-(4-tert-butylphenyl)quinolin-4-yl]methanone
CAS 438232-55-4C25H22BrF4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-chlorophenyl)quinolin-4-yl]methanone chemical structure, C21H14ClF4N3O2, CAS 438236-42-1
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2-chlorophenyl)quinolin-4-yl]methanone
CAS 438236-42-1C21H14ClF4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-ethylphenyl)quinolin-4-yl]methanone chemical structure, C23H19F4N3O2, CAS 438234-40-3
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(4-ethylphenyl)quinolin-4-yl]methanone
CAS 438234-40-3C23H19F4N3O2
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2,4-dimethylphenyl)quinolin-4-yl]methanone chemical structure, C23H19F4N3O2, CAS 438231-55-1
[3,5-Bis(difluoromethyl)-5-hydroxy-4H-pyrazol-1-yl]-[2-(2,4-dimethylphenyl)quinolin-4-yl]methanone
CAS 438231-55-1C23H19F4N3O2