Murcko scaffold

Ring system with 5 rings and 29 atoms

47 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 29
Chemicals: 47
With full pages: 3

Scaffold SMILES

O=S(=O)(c1ccccc1)c1nnn2c1nc(NCc1ccccc1)c1sccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=S(=O)(c1ccccc1)c1nnn2c1nc(NCc1ccccc1)c1sccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

N-(4-Fluorobenzyl)-3-tosylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892732-88-6C₂₁H₁₆FN₅O₂S₂

$N-Benzyl-10-(4-chlorobenzenesulfonyl)-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C20H14ClN5O2S2, CAS 892736-74-2$

N-Benzyl-10-(4-chlorobenzenesulfonyl)-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892736-74-2C₂₀H₁₄ClN₅O₂S₂

N-(4-Chlorobenzyl)-3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892730-07-3C₂₀H₁₄ClN₅O₂S₂

N-(4-Methylbenzyl)-3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892730-17-5C₂₁H₁₇N₅O₂S₂

N-(4-Fluorobenzyl)-3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892730-49-3C₂₀H₁₄FN₅O₂S₂

N-(1-Phenylethyl)-3-tosylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892732-35-3C₂₂H₁₉N₅O₂S₂

$10-(4-Bromobenzenesulfonyl)-N-[(4-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C21H16BrN5O3S2, CAS 892748-34-4$

10-(4-Bromobenzenesulfonyl)-N-[(4-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892748-34-4C₂₁H₁₆BrN₅O₃S₂

$10-(4-Bromobenzenesulfonyl)-N-(1-phenylethyl)-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C21H16BrN5O2S2, CAS 892748-97-9$

10-(4-Bromobenzenesulfonyl)-N-(1-phenylethyl)-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892748-97-9C₂₁H₁₆BrN₅O₂S₂

$10-(4-Bromobenzenesulfonyl)-N-[(3-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C21H16BrN5O3S2, CAS 892749-04-1$

10-(4-Bromobenzenesulfonyl)-N-[(3-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892749-04-1C₂₁H₁₆BrN₅O₃S₂

$N-Benzyl-10-(4-bromobenzenesulfonyl)-N-ethyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C22H18BrN5O2S2, CAS 892749-11-0$

N-Benzyl-10-(4-bromobenzenesulfonyl)-N-ethyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892749-11-0C₂₂H₁₈BrN₅O₂S₂

$N-[(4-Methylphenyl)methyl]-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C24H23N5O2S2, CAS 892739-79-6$

N-[(4-Methylphenyl)methyl]-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892739-79-6C₂₄H₂₃N₅O₂S₂

$N-[(4-Methoxyphenyl)methyl]-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C24H23N5O3S2, CAS 892739-49-0$

N-[(4-Methoxyphenyl)methyl]-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892739-49-0C₂₄H₂₃N₅O₃S₂

3-((4-Isopropylphenyl)sulfonyl)-N-(3-methoxybenzyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892740-03-3C₂₄H₂₃N₅O₃S₂

$N-Benzyl-N-methyl-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C24H23N5O2S2, CAS 892740-60-2$

N-Benzyl-N-methyl-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892740-60-2C₂₄H₂₃N₅O₂S₂

$N-Benzyl-N-ethyl-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C25H25N5O2S2, CAS 892740-09-9$

N-Benzyl-N-ethyl-10-[4-(propan-2-yl)benzenesulfonyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892740-09-9C₂₅H₂₅N₅O₂S₂

$10-(4-Ethylbenzenesulfonyl)-N-(1-phenylethyl)-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C23H21N5O2S2, CAS 892742-40-4$

10-(4-Ethylbenzenesulfonyl)-N-(1-phenylethyl)-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892742-40-4C₂₃H₂₁N₅O₂S₂

$N-Benzyl-10-(4-ethylbenzenesulfonyl)-N-methyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C23H21N5O2S2, CAS 892742-98-2$

N-Benzyl-10-(4-ethylbenzenesulfonyl)-N-methyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892742-98-2C₂₃H₂₁N₅O₂S₂

$10-(2,5-Dimethylbenzenesulfonyl)-N-[(4-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C23H21N5O3S2, CAS 892745-00-5$

10-(2,5-Dimethylbenzenesulfonyl)-N-[(4-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892745-00-5C₂₃H₂₁N₅O₃S₂

$10-(2,5-Dimethylbenzenesulfonyl)-N-[(3-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C23H21N5O3S2, CAS 892745-70-9$

10-(2,5-Dimethylbenzenesulfonyl)-N-[(3-methoxyphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892745-70-9C₂₃H₂₁N₅O₃S₂

$N-Benzyl-10-(2,5-dimethylbenzenesulfonyl)-N-ethyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C24H23N5O2S2, CAS 892745-77-6$

N-Benzyl-10-(2,5-dimethylbenzenesulfonyl)-N-ethyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892745-77-6C₂₄H₂₃N₅O₂S₂

$N-Benzyl-10-(2,5-dimethylbenzenesulfonyl)-N-methyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C23H21N5O2S2, CAS 892746-54-2$

N-Benzyl-10-(2,5-dimethylbenzenesulfonyl)-N-methyl-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892746-54-2C₂₃H₂₁N₅O₂S₂

N-(2-Chlorobenzyl)-3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892730-03-9C₂₀H₁₄ClN₅O₂S₂

N-(4-Chlorobenzyl)-3-[(4-methylphenyl)sulfonyl]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

CAS 892732-01-3C₂₁H₁₆ClN₅O₂S₂

$10-(4-Methylbenzenesulfonyl)-N-[(4-methylphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine chemical structure, C22H19N5O2S2, CAS 892732-27-3$

10-(4-Methylbenzenesulfonyl)-N-[(4-methylphenyl)methyl]-5-thia-1,8,11,12-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),3,7,9,11-pentaen-7-amine

CAS 892732-27-3C₂₂H₁₉N₅O₂S₂