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Murcko scaffold

Ring system with 4 rings and 21 atoms

36 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
36
With full pages
8
Scaffold SMILES

O=C(Nc1ccccc1)C1OC2OCOC2C2OCOC12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1OC2OCOC2C2OCOC12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

2,2,7,7-Tetramethyl-tetrahydrobis[1,3]dioxolo[4,5-b:4',5'-d]pyran-5-carboxylic acid, phenylamide chemical structure, C18H23NO6, CAS 347412-23-1
2,2,7,7-Tetramethyl-tetrahydrobis[1,3]dioxolo[4,5-b:4',5'-d]pyran-5-carboxylic acid, phenylamide
CAS 347412-23-1C18H23NO6
2,2,7,7-Tetramethyl-N-(4-methylphenyl)tetrahydro-3aH-di[1,3]dioxolo[4,5-b:4,5-d]pyran-5-carboxamide chemical structure, C19H25NO6, CAS 347412-24-2
2,2,7,7-Tetramethyl-N-(4-methylphenyl)tetrahydro-3aH-di[1,3]dioxolo[4,5-b:4,5-d]pyran-5-carboxamide
CAS 347412-24-2C19H25NO6
4,4,11,11-Tetramethyl-N-[4-(3-methylbutoxy)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C23H33NO7, CAS 1095323-51-5
4,4,11,11-Tetramethyl-N-[4-(3-methylbutoxy)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1095323-51-5C23H33NO7
N-(3-Methoxyphenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C19H25NO7, CAS 1093407-67-0
N-(3-Methoxyphenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093407-67-0C19H25NO7
N-(3-Chloro-4-fluorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C18H21ClFNO6, CAS 1093406-43-9
N-(3-Chloro-4-fluorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093406-43-9C18H21ClFNO6
4,4,11,11-Tetramethyl-N-[4-(trifluoromethoxy)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C19H22F3NO7, CAS 1095321-41-7
4,4,11,11-Tetramethyl-N-[4-(trifluoromethoxy)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1095321-41-7C19H22F3NO7
N-(4-Chlorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C18H22ClNO6, CAS 1093406-42-8
N-(4-Chlorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093406-42-8C18H22ClNO6
(5aS,8aR)-N-(3-Chloro-4-methylphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C19H24ClNO6, CAS 1093730-64-3
(5aS,8aR)-N-(3-Chloro-4-methylphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1093730-64-3C19H24ClNO6
N-(4-acetylphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C20H25NO7, CAS 1093407-66-9
N-(4-acetylphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1093407-66-9C20H25NO7
Ethyl 4-(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamido)benzoate chemical structure, C21H27NO8, CAS 1093406-40-6
Ethyl 4-(2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamido)benzoate
CAS 1093406-40-6C21H27NO8
4,4,11,11-Tetramethyl-N-[3-(trifluoromethyl)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C19H22F3NO6, CAS 1093405-84-5
4,4,11,11-Tetramethyl-N-[3-(trifluoromethyl)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093405-84-5C19H22F3NO6
N-(2-fluorophenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C18H22FNO6, CAS 1009038-96-3
N-(2-fluorophenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1009038-96-3C18H22FNO6
C18H22Fno6 chemical structure, C18H22FNO6, CAS 1008410-90-9
C18H22Fno6
CAS 1008410-90-9C18H22FNO6
N-(4-fluorophenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C18H22FNO6, CAS 1008577-26-1
N-(4-fluorophenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1008577-26-1C18H22FNO6
N-(3-Acetylphenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C20H25NO7, CAS 1093684-00-4
N-(3-Acetylphenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093684-00-4C20H25NO7
N-(2,5-Difluorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C18H21F2NO6, CAS 1095762-80-3
N-(2,5-Difluorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1095762-80-3C18H21F2NO6
N-(3,4-Difluorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C18H21F2NO6, CAS 1294455-27-8
N-(3,4-Difluorophenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1294455-27-8C18H21F2NO6
N-(2,5-dimethylphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C20H27NO6, CAS 1008274-97-2
N-(2,5-dimethylphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1008274-97-2C20H27NO6
4,4,11,11-Tetramethyl-N-[2-(trifluoromethyl)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C19H22F3NO6, CAS 1093407-91-0
4,4,11,11-Tetramethyl-N-[2-(trifluoromethyl)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093407-91-0C19H22F3NO6
2,2,7,7-Tetramethyl-N-(2-(methylthio)phenyl)tetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C19H25NO6S, CAS 1008577-21-6
2,2,7,7-Tetramethyl-N-(2-(methylthio)phenyl)tetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1008577-21-6C19H25NO6S
N-(5-chloro-2-methoxyphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C19H24ClNO7, CAS 1093407-93-2
N-(5-chloro-2-methoxyphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1093407-93-2C19H24ClNO7
N-(2,4-Dimethoxyphenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C20H27NO8, CAS 1093407-96-5
N-(2,4-Dimethoxyphenyl)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093407-96-5C20H27NO8
4,4,11,11-Tetramethyl-N-[4-(propan-2-yl)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide chemical structure, C21H29NO6, CAS 1093407-97-6
4,4,11,11-Tetramethyl-N-[4-(propan-2-yl)phenyl]-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecane-8-carboxamide
CAS 1093407-97-6C21H29NO6
N-(4-ethoxyphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide chemical structure, C20H27NO7, CAS 1093407-99-8
N-(4-ethoxyphenyl)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-5-carboxamide
CAS 1093407-99-8C20H27NO7