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Murcko scaffold

Ring system with 3 rings and 19 atoms

46 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
46
With full pages
8
Scaffold SMILES

O=C1Nc2ccccc2C1=CC(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C1=CC(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 46 of 46 chemicals

5-Bromo-3-phenacylidene-1H-indol-2-one chemical structure, C16H10BrNO2
5-Bromo-3-phenacylidene-1H-indol-2-one
C16H10BrNO2
2H-Indol-2-one, 1,3-dihydro-5-methyl-3-(2-oxo-2-phenylethylidene)- chemical structure, C17H13NO2, CAS 70452-31-2
2H-Indol-2-one, 1,3-dihydro-5-methyl-3-(2-oxo-2-phenylethylidene)-
CAS 70452-31-2C17H13NO2
(3Z)-3-[2-(4-Chlorophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C16H10ClNO2, CAS 23336-93-8
(3Z)-3-[2-(4-Chlorophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
CAS 23336-93-8C16H10ClNO2
(3E)-3-Phenacylidene-1H-indol-2-one chemical structure, C16H11NO2, CAS 56680-29-6
(3E)-3-Phenacylidene-1H-indol-2-one
CAS 56680-29-6C16H11NO2
(3Z)-3-(2-Oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C16H11NO2, CAS 31541-36-3
(3Z)-3-(2-Oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one
CAS 31541-36-3C16H11NO2
(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-1H-indol-2-one chemical structure, C16H10FNO2, CAS 1512758-87-0
(3Z)-3-[2-(4-Fluorophenyl)-2-oxoethylidene]-1H-indol-2-one
CAS 1512758-87-0C16H10FNO2
2H-Indol-2-one, 3-[2-(4-fluorophenyl)-2-oxoethylidene]-1,3-dihydro- chemical structure, C16H10FNO2, CAS 98711-39-8
2H-Indol-2-one, 3-[2-(4-fluorophenyl)-2-oxoethylidene]-1,3-dihydro-
CAS 98711-39-8C16H10FNO2
(Z)-3-(2-(4-Methoxyphenyl)-2-oxoethylidene)indolin-2-one chemical structure, C17H13NO3, CAS 159862-03-0
(Z)-3-(2-(4-Methoxyphenyl)-2-oxoethylidene)indolin-2-one
CAS 159862-03-0C17H13NO3
(Z)-3-(2-(4-(2-Chloroethyl)phenyl)-2-oxoethylidene)indolin-2-one chemical structure, C18H14ClNO2, CAS 317842-32-3
(Z)-3-(2-(4-(2-Chloroethyl)phenyl)-2-oxoethylidene)indolin-2-one
CAS 317842-32-3C18H14ClNO2
3-[2-(4-Methylphenyl)-2-oxoethylidene]-2,3-dihydro-1H-indol-2-one chemical structure, C17H13NO2, CAS 637778-35-9
3-[2-(4-Methylphenyl)-2-oxoethylidene]-2,3-dihydro-1H-indol-2-one
CAS 637778-35-9C17H13NO2
(3E)-3-[2-(3,4-Dimethoxyphenyl)-2-oxoethylidene]-1H-indol-2-one chemical structure, C18H15NO4, CAS 370577-17-6
(3E)-3-[2-(3,4-Dimethoxyphenyl)-2-oxoethylidene]-1H-indol-2-one
CAS 370577-17-6C18H15NO4
(3Z)-3-[2-(4-Bromophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C16H10BrNO2, CAS 159867-42-2
(3Z)-3-[2-(4-Bromophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
CAS 159867-42-2C16H10BrNO2
(3Z)-3-[2-(3-Methoxyphenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C17H13NO3, CAS 120422-07-3
(3Z)-3-[2-(3-Methoxyphenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
CAS 120422-07-3C17H13NO3
3-(4-Bromophenacylidene)-1-methyl-2-indolinone chemical structure, C17H12BrNO2, CAS 846-98-0
3-(4-Bromophenacylidene)-1-methyl-2-indolinone
CAS 846-98-0C17H12BrNO2
(3Z)-3-[2-Oxo-2-(3,4,5-trimethoxyphenyl)ethylidene]-1H-indol-2-one chemical structure, C19H17NO5, CAS 384363-88-6
(3Z)-3-[2-Oxo-2-(3,4,5-trimethoxyphenyl)ethylidene]-1H-indol-2-one
CAS 384363-88-6C19H17NO5
3-[2-(4-Fluorophenyl)-2-oxoethylidene]-2,3-dihydro-1H-indol-2-one chemical structure, C16H10FNO2, CAS 1867188-99-5
3-[2-(4-Fluorophenyl)-2-oxoethylidene]-2,3-dihydro-1H-indol-2-one
CAS 1867188-99-5C16H10FNO2
(3Z)-1-Acetyl-3-[2-(4-nitrophenyl)-2-oxoethylidene]indol-2-one chemical structure, C18H12N2O5, CAS 5238-39-1
(3Z)-1-Acetyl-3-[2-(4-nitrophenyl)-2-oxoethylidene]indol-2-one
CAS 5238-39-1C18H12N2O5
5-Bromo-1,3-dihydro-3-[2-(3-nitrophenyl)-2-oxoethylidene]-2H-indol-2-one chemical structure, C16H9BrN2O4, CAS 258264-71-0
5-Bromo-1,3-dihydro-3-[2-(3-nitrophenyl)-2-oxoethylidene]-2H-indol-2-one
CAS 258264-71-0C16H9BrN2O4
2H-Indol-2-one, 1,3-dihydro-3-[2-(4-methylphenyl)-2-oxoethylidene]- chemical structure, C17H13NO2, CAS 66447-80-1
2H-Indol-2-one, 1,3-dihydro-3-[2-(4-methylphenyl)-2-oxoethylidene]-
CAS 66447-80-1C17H13NO2
2H-Indol-2-one, 1,3-dihydro-3-[2-(4-methoxyphenyl)-2-oxoethylidene]- chemical structure, C17H13NO3, CAS 66447-82-3
2H-Indol-2-one, 1,3-dihydro-3-[2-(4-methoxyphenyl)-2-oxoethylidene]-
CAS 66447-82-3C17H13NO3
2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-(2-oxo-2-phenylethylidene)- chemical structure, C16H10FNO2, CAS 91021-14-6
2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-(2-oxo-2-phenylethylidene)-
CAS 91021-14-6C16H10FNO2
(3E)-5-Bromo-3-phenacylidene-1H-indol-2-one chemical structure, C16H10BrNO2
(3E)-5-Bromo-3-phenacylidene-1H-indol-2-one
C16H10BrNO2
5-Bromo-3-(2-oxo-2-phenylethylidene)indolin-2-one chemical structure, C16H10BrNO2, CAS 70452-30-1
5-Bromo-3-(2-oxo-2-phenylethylidene)indolin-2-one
CAS 70452-30-1C16H10BrNO2
(3Z)-5,7-Dimethyl-3-phenacylidene-1H-indol-2-one chemical structure, C18H15NO2, CAS 70452-33-4
(3Z)-5,7-Dimethyl-3-phenacylidene-1H-indol-2-one
CAS 70452-33-4C18H15NO2