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Murcko scaffold

1(3H)-Isobenzofuranone, 3-(2-oxo-2-phenylethyl)- scaffold

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
36
With full pages
11
Scaffold SMILES

O=C(CC1OC(=O)c2ccccc21)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1(3H)-Isobenzofuranone, 3-(2-oxo-2-phenylethyl)- page
Murcko scaffold O=C(CC1OC(=O)c2ccccc21)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

3-(2-Hydroxyphenacyl)phthalide chemical structure, C16H12O4, CAS 16821-00-4
3-(2-Hydroxyphenacyl)phthalide
CAS 16821-00-4C16H12O4
3-[2-(2,5-Dimethoxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one chemical structure, C18H16O5, CAS 73270-78-7
3-[2-(2,5-Dimethoxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one
CAS 73270-78-7C18H16O5
3-[2-(4-Methylphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one chemical structure, C17H14O3, CAS 69322-22-1
3-[2-(4-Methylphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one
CAS 69322-22-1C17H14O3
3-(4-Nitrophenacyl)phthalide chemical structure, C16H11NO5, CAS 69322-20-9
3-(4-Nitrophenacyl)phthalide
CAS 69322-20-9C16H11NO5
3-[2-(4-Methoxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one chemical structure, C17H14O4, CAS 55222-45-2
3-[2-(4-Methoxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one
CAS 55222-45-2C17H14O4
3-(4-Fluorophenacyl)-1,3-dihydroisobenzofuran-1-one chemical structure, C16H11FO3, CAS 55222-59-8
3-(4-Fluorophenacyl)-1,3-dihydroisobenzofuran-1-one
CAS 55222-59-8C16H11FO3
3-(2-(4-Chlorophenyl)-2-oxoethyl)-1(3H)-isobenzofuranone chemical structure, C16H11ClO3, CAS 69322-23-2
3-(2-(4-Chlorophenyl)-2-oxoethyl)-1(3H)-isobenzofuranone
CAS 69322-23-2C16H11ClO3
3-[2-(4-Chlorophenyl)-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one chemical structure, C18H15ClO5, CAS 313648-84-9
3-[2-(4-Chlorophenyl)-2-oxoethyl]-6,7-dimethoxy-2-benzofuran-1(3H)-one
CAS 313648-84-9C18H15ClO5
3-(2-(4-Fluorophenyl)-2-oxoethyl)-6,7-dimethoxyisobenzofuran-1(3H)-one chemical structure, C18H15FO5, CAS 330202-39-6
3-(2-(4-Fluorophenyl)-2-oxoethyl)-6,7-dimethoxyisobenzofuran-1(3H)-one
CAS 330202-39-6C18H15FO5
3-[2-(5-Chloro-2-hydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one chemical structure, C18H15ClO6, CAS 313231-84-4
3-[2-(5-Chloro-2-hydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one
CAS 313231-84-4C18H15ClO6
3-[2-(4-Hydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one chemical structure, C18H16O6, CAS 322669-32-9
3-[2-(4-Hydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one
CAS 322669-32-9C18H16O6
1(3H)-Isobenzofuranone, 3-(2-oxo-2-phenylethyl)- chemical structure, C16H12O3, CAS 13203-89-9
1(3H)-Isobenzofuranone, 3-(2-oxo-2-phenylethyl)-
CAS 13203-89-9C16H12O3
6,7-Dimethoxy-3-(2-(4-methoxyphenyl)-2-oxoethyl)isobenzofuran-1(3H)-one chemical structure, C19H18O6, CAS 313648-83-8
6,7-Dimethoxy-3-(2-(4-methoxyphenyl)-2-oxoethyl)isobenzofuran-1(3H)-one
CAS 313648-83-8C19H18O6
6,7-Dimethoxy-3-(2-oxo-2-phenylethyl)-2-benzofuran-1(3H)-one chemical structure, C18H16O5, CAS 302938-38-1
6,7-Dimethoxy-3-(2-oxo-2-phenylethyl)-2-benzofuran-1(3H)-one
CAS 302938-38-1C18H16O5
6,7-Dimethoxy-3-[2-(4-nitrophenyl)-2-oxoethyl]-3H-2-benzofuran-1-one chemical structure, C18H15NO7, CAS 312927-87-0
6,7-Dimethoxy-3-[2-(4-nitrophenyl)-2-oxoethyl]-3H-2-benzofuran-1-one
CAS 312927-87-0C18H15NO7
3-[2-(4-Iodophenyl)-2-oxoethyl]-3H-2-benzofuran-1-one chemical structure, C16H11IO3, CAS 378218-33-8
3-[2-(4-Iodophenyl)-2-oxoethyl]-3H-2-benzofuran-1-one
CAS 378218-33-8C16H11IO3
3-[2-(4-Hydroxy-3-iodophenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one chemical structure, C18H15IO6, CAS 337932-92-0
3-[2-(4-Hydroxy-3-iodophenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one
CAS 337932-92-0C18H15IO6
3-(2-(2,5-Dihydroxyphenyl)-2-oxoethyl)isobenzofuran-1(3H)-one chemical structure, C16H12O5, CAS 423746-49-0
3-(2-(2,5-Dihydroxyphenyl)-2-oxoethyl)isobenzofuran-1(3H)-one
CAS 423746-49-0C16H12O5
3-[2-(3-Hydroxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one chemical structure, C16H12O4, CAS 177747-89-6
3-[2-(3-Hydroxyphenyl)-2-oxoethyl]-3H-2-benzofuran-1-one
CAS 177747-89-6C16H12O4
3-(2-(4-Bromophenyl)-2-oxoethyl)isobenzofuran-1(3H)-one chemical structure, C16H11BrO3, CAS 702648-88-2
3-(2-(4-Bromophenyl)-2-oxoethyl)isobenzofuran-1(3H)-one
CAS 702648-88-2C16H11BrO3
3-(2-(4-Hydroxy-3,5-diiodophenyl)-2-oxoethyl)-6,7-dimethoxyisobenzofuran-1(3H)-one chemical structure, C18H14I2O6, CAS 330447-19-3
3-(2-(4-Hydroxy-3,5-diiodophenyl)-2-oxoethyl)-6,7-dimethoxyisobenzofuran-1(3H)-one
CAS 330447-19-3C18H14I2O6
3-[2-(5-Fluoro-2-hydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one chemical structure, C18H15FO6, CAS 375353-92-7
3-[2-(5-Fluoro-2-hydroxyphenyl)-2-oxoethyl]-6,7-dimethoxy-3H-2-benzofuran-1-one
CAS 375353-92-7C18H15FO6
3-[2-(2-Methoxyphenyl)-2-oxoethyl]-2-benzofuran-1(3H)-one chemical structure, C17H14O4, CAS 55377-56-5
3-[2-(2-Methoxyphenyl)-2-oxoethyl]-2-benzofuran-1(3H)-one
CAS 55377-56-5C17H14O4
3-(2-Oxo-2-(3,4,5-trimethoxyphenyl)ethyl)isobenzofuran-1(3H)-one chemical structure, C19H18O6, CAS 881446-59-9
3-(2-Oxo-2-(3,4,5-trimethoxyphenyl)ethyl)isobenzofuran-1(3H)-one
CAS 881446-59-9C19H18O6