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Murcko scaffold

Ring system with 3 rings and 23 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
9
With full pages
4
Scaffold SMILES

O=C(C=CC=Cc1ccccc1)CC1C(=O)Nc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=CC=Cc1ccccc1)CC1C(=O)Nc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

3-Hydroxy-3-(2-oxo-6-phenylhexa-3,5-dienyl)-1H-indol-2-one chemical structure, C20H17NO3
3-Hydroxy-3-(2-oxo-6-phenylhexa-3,5-dienyl)-1H-indol-2-one
C20H17NO3
5-Bromo-3-hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dienyl]-1H-indol-2-one chemical structure, C20H16BrNO3, CAS 362506-69-2
5-Bromo-3-hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dienyl]-1H-indol-2-one
CAS 362506-69-2C20H16BrNO3
1-Ethyl-3-hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-1,3-dihydro-2H-indol-2-one chemical structure, C22H21NO3, CAS 1164492-12-9
1-Ethyl-3-hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-1,3-dihydro-2H-indol-2-one
CAS 1164492-12-9C22H21NO3
Ethyl {3-hydroxy-2-oxo-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C24H23NO5, CAS 369392-62-1
Ethyl {3-hydroxy-2-oxo-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-2,3-dihydro-1H-indol-1-yl}acetate
CAS 369392-62-1C24H23NO5
3-Hydroxy-1-methyl-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dienyl]indol-2-one chemical structure, C21H19NO3, CAS 1164467-83-7
3-Hydroxy-1-methyl-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dienyl]indol-2-one
CAS 1164467-83-7C21H19NO3
3-Hydroxy-5-methyl-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dienyl]-1H-indol-2-one chemical structure, C21H19NO3, CAS 1164491-44-4
3-Hydroxy-5-methyl-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dienyl]-1H-indol-2-one
CAS 1164491-44-4C21H19NO3
5-Chloro-3-hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-1,3-dihydro-2H-indol-2-one chemical structure, C20H16ClNO3, CAS 434292-49-6
5-Chloro-3-hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-1,3-dihydro-2H-indol-2-one
CAS 434292-49-6C20H16ClNO3
3-Hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C23H21NO3, CAS 434294-02-7
3-Hydroxy-3-[(3E,5E)-2-oxo-6-phenylhexa-3,5-dien-1-yl]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one
CAS 434294-02-7C23H21NO3
SARS-CoV-2 Mpro-IN-12 chemical structure, C20H17NO3, CAS 370583-15-6
SARS-CoV-2 Mpro-IN-12
CAS 370583-15-6C20H17NO3