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Murcko scaffold

Ring system with 2 rings and 16 atoms

66 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
66
With full pages
8
Scaffold SMILES

O=C(Nc1cnc[nH]c1=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cnc[nH]c1=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 66 of 66 chemicals

N-(4-Amino-2-((2-((2-methoxyethyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-ethoxybenzamide chemical structure, C18H23N5O5S, CAS 888440-52-6
N-(4-Amino-2-((2-((2-methoxyethyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-ethoxybenzamide
CAS 888440-52-6C18H23N5O5S
Ethyl 2-(2-((4-amino-5-(4-ethoxybenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamido)acetate chemical structure, C19H23N5O6S, CAS 888418-34-6
Ethyl 2-(2-((4-amino-5-(4-ethoxybenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamido)acetate
CAS 888418-34-6C19H23N5O6S
Methyl 2-((4-amino-5-(4-ethoxybenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)butanoate chemical structure, C18H22N4O5S, CAS 888420-15-3
Methyl 2-((4-amino-5-(4-ethoxybenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)butanoate
CAS 888420-15-3C18H22N4O5S
2-((4-Amino-5-(4-ethoxybenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)propanoic acid chemical structure, C16H18N4O5S, CAS 888420-50-6
2-((4-Amino-5-(4-ethoxybenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)propanoic acid
CAS 888420-50-6C16H18N4O5S
N-(4-Acetamido-2-((2-((2-methoxyethyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide chemical structure, C18H21N5O5S, CAS 872608-63-4
N-(4-Acetamido-2-((2-((2-methoxyethyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide
CAS 872608-63-4C18H21N5O5S
N-(4-Amino-2-((2-(methylamino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide chemical structure, C14H15N5O3S, CAS 888428-18-0
N-(4-Amino-2-((2-(methylamino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide
CAS 888428-18-0C14H15N5O3S
N-(4-Amino-2-((2-hydroxyethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide chemical structure, C13H14N4O3S, CAS 888429-39-8
N-(4-Amino-2-((2-hydroxyethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide
CAS 888429-39-8C13H14N4O3S
N-(4-Amino-2-((2-(isopropylamino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-fluorobenzamide chemical structure, C16H18FN5O3S, CAS 888415-73-4
N-(4-Amino-2-((2-(isopropylamino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-fluorobenzamide
CAS 888415-73-4C16H18FN5O3S
N-(4-Amino-2-((2-(diethylamino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-fluorobenzamide chemical structure, C17H20FN5O3S, CAS 888418-43-7
N-(4-Amino-2-((2-(diethylamino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-fluorobenzamide
CAS 888418-43-7C17H20FN5O3S
2,6-Dimethyl-4-hydroxy-5-benzamidopyrimidine chemical structure, C13H13N3O2, CAS 237435-09-5
2,6-Dimethyl-4-hydroxy-5-benzamidopyrimidine
CAS 237435-09-5C13H13N3O2
N-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)benzamide chemical structure, C11H11N5O2, CAS 14091-60-2
N-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)benzamide
CAS 14091-60-2C11H11N5O2
N-(4-Amino-2-((2-((2-methoxyethyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide chemical structure, C16H19N5O4S, CAS 872596-66-2
N-(4-Amino-2-((2-((2-methoxyethyl)amino)-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)benzamide
CAS 872596-66-2C16H19N5O4S
N-(4-Amino-2-((2-ethoxyethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-methoxybenzamide chemical structure, C16H20N4O4S, CAS 872597-34-7
N-(4-Amino-2-((2-ethoxyethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-methoxybenzamide
CAS 872597-34-7C16H20N4O4S
N-(4-Amino-2-(methylthio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-ethoxybenzamide chemical structure, C14H16N4O3S, CAS 872597-68-7
N-(4-Amino-2-(methylthio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-ethoxybenzamide
CAS 872597-68-7C14H16N4O3S
N-(4-Amino-2-((2-methoxyethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-ethoxybenzamide chemical structure, C16H20N4O4S, CAS 872597-69-8
N-(4-Amino-2-((2-methoxyethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-ethoxybenzamide
CAS 872597-69-8C16H20N4O4S
2-((4-Amino-5-(3,4-difluorobenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetic acid chemical structure, C13H10F2N4O4S, CAS 872608-50-9
2-((4-Amino-5-(3,4-difluorobenzamido)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetic acid
CAS 872608-50-9C13H10F2N4O4S
N-(4-Acetamido-2-((2-amino-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-fluorobenzamide chemical structure, C15H14FN5O4S, CAS 872608-78-1
N-(4-Acetamido-2-((2-amino-2-oxoethyl)thio)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-fluorobenzamide
CAS 872608-78-1C15H14FN5O4S
N-(4-Amino-6-oxo-1,6-dihydropyrimidin-5-yl)-5-iodo-2-methylbenzamide chemical structure, C12H11IN4O2, CAS 2561455-18-1
N-(4-Amino-6-oxo-1,6-dihydropyrimidin-5-yl)-5-iodo-2-methylbenzamide
CAS 2561455-18-1C12H11IN4O2