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Murcko scaffold

Ring system with 5 rings and 27 atoms

19 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
27
Chemicals
19
With full pages
3
Scaffold SMILES

O=c1c(=Cc2cccc3ccccc23)sc2n1C(c1ccccc1)C=CN=2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(=Cc2cccc3ccccc23)sc2n1C(c1ccccc1)C=CN=2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

Ethyl 7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-5-(4-prop-2-enoxyphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H26N2O4S, CAS 6163-03-7
Ethyl 7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-5-(4-prop-2-enoxyphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 6163-03-7C30H26N2O4S
(Z)-Ethyl 5-(4-(dimethylamino)phenyl)-2-((2-methoxynaphthalen-1-yl)methylene)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H29N3O4S, CAS 327055-92-5
(Z)-Ethyl 5-(4-(dimethylamino)phenyl)-2-((2-methoxynaphthalen-1-yl)methylene)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 327055-92-5C30H29N3O4S
Ethyl (2Z)-2-[(2-methoxynaphthalen-1-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H26N2O5S, CAS 327055-52-7
Ethyl (2Z)-2-[(2-methoxynaphthalen-1-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 327055-52-7C29H26N2O5S
(2Z)-6-Acetyl-2-[(2-ethoxynaphthalen-1-yl)methylidene]-5-(2-methoxyphenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-one chemical structure, C29H26N2O4S, CAS 292877-44-2
(2Z)-6-Acetyl-2-[(2-ethoxynaphthalen-1-yl)methylidene]-5-(2-methoxyphenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-one
CAS 292877-44-2C29H26N2O4S
(2Z)-6-Acetyl-2-[(2,7-dimethoxynaphthalen-1-yl)methylidene]-5-(2-methoxyphenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-one chemical structure, C29H26N2O5S, CAS 292876-50-7
(2Z)-6-Acetyl-2-[(2,7-dimethoxynaphthalen-1-yl)methylidene]-5-(2-methoxyphenyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-3-one
CAS 292876-50-7C29H26N2O5S
Ethyl (2Z)-2-[(2-ethoxynaphthalen-1-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H28N2O5S, CAS 313068-37-0
Ethyl (2Z)-2-[(2-ethoxynaphthalen-1-yl)methylidene]-5-(4-methoxyphenyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 313068-37-0C30H28N2O5S
Ethyl (2Z)-5-(2-chlorophenyl)-2-[(2-methoxynaphthalen-1-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H23ClN2O4S, CAS 354556-96-0
Ethyl (2Z)-5-(2-chlorophenyl)-2-[(2-methoxynaphthalen-1-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 354556-96-0C28H23ClN2O4S
Ethyl (2Z)-2-[(2-ethoxynaphthalen-1-yl)methylidene]-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C30H28N2O4S, CAS 354561-90-3
Ethyl (2Z)-2-[(2-ethoxynaphthalen-1-yl)methylidene]-7-methyl-5-(4-methylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 354561-90-3C30H28N2O4S
Ethyl (2Z)-5-(4-chlorophenyl)-2-[(2-ethoxynaphthalen-1-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H25ClN2O4S, CAS 313068-72-3
Ethyl (2Z)-5-(4-chlorophenyl)-2-[(2-ethoxynaphthalen-1-yl)methylidene]-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 313068-72-3C29H25ClN2O4S
Ethyl (2Z)-2-[(2-methoxynaphthalen-1-yl)methylidene]-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H26N2O4S2, CAS 5816-75-1
Ethyl (2Z)-2-[(2-methoxynaphthalen-1-yl)methylidene]-7-methyl-5-(4-methylsulfanylphenyl)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 5816-75-1C29H26N2O4S2
Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H24N2O4S, CAS 324568-74-3
Ethyl (2Z)-5-(4-methoxyphenyl)-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324568-74-3C28H24N2O4S
Ethyl (2Z)-5-(3,4-dimethoxyphenyl)-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H26N2O5S, CAS 324567-68-2
Ethyl (2Z)-5-(3,4-dimethoxyphenyl)-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324567-68-2C29H26N2O5S
Ethyl (2Z)-2-[(2-methoxynaphthalen-1-yl)methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C28H24N2O4S, CAS 327055-16-3
Ethyl (2Z)-2-[(2-methoxynaphthalen-1-yl)methylidene]-7-methyl-3-oxo-5-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 327055-16-3C28H24N2O4S
(Z)-Ethyl 5-(2-chlorophenyl)-2-((2-ethoxynaphthalen-1-yl)methylene)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H25ClN2O4S, CAS 381185-37-1
(Z)-Ethyl 5-(2-chlorophenyl)-2-((2-ethoxynaphthalen-1-yl)methylene)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 381185-37-1C29H25ClN2O4S
Methyl (2Z)-5-(2-chlorophenyl)-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C26H19ClN2O3S, CAS 324567-58-0
Methyl (2Z)-5-(2-chlorophenyl)-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324567-58-0C26H19ClN2O3S
Methyl (2Z)-5-(4-(methoxycarbonyl)phenyl)-7-methyl-2-(1-naphthylmethylene)-3-OX O-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate chemical structure, C28H22N2O5S, CAS 609795-01-9
Methyl (2Z)-5-(4-(methoxycarbonyl)phenyl)-7-methyl-2-(1-naphthylmethylene)-3-OX O-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate
CAS 609795-01-9C28H22N2O5S
Ethyl (2Z)-5-[4-(acetyloxy)phenyl]-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C29H24N2O5S, CAS 324568-23-2
Ethyl (2Z)-5-[4-(acetyloxy)phenyl]-7-methyl-2-(naphthalen-1-ylmethylidene)-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324568-23-2C29H24N2O5S
Ethyl (2E)-7-methyl-2-(1-naphthylmethylene)-3-oxo-5-phenyl-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate chemical structure, C27H22N2O3S, CAS 324568-33-4
Ethyl (2E)-7-methyl-2-(1-naphthylmethylene)-3-oxo-5-phenyl-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate
CAS 324568-33-4C27H22N2O3S
Ethyl (2E)-7-methyl-5-[4-(methylsulfanyl)phenyl]-2-(1-naphthylmethylene)-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-A]pyrimidine-6-carboxylate chemical structure, C28H24N2O3S2, CAS 357438-61-0
Ethyl (2E)-7-methyl-5-[4-(methylsulfanyl)phenyl]-2-(1-naphthylmethylene)-3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-A]pyrimidine-6-carboxylate
CAS 357438-61-0C28H24N2O3S2