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Murcko scaffold

Ring system with 3 rings and 18 atoms

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
15
With full pages
4
Scaffold SMILES

O=C1CC(c2ccccc2)c2c([nH]cnc2=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)c2c([nH]cnc2=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

5-(4-Chlorophenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione chemical structure, C15H14ClN3O2S, CAS 878433-65-9
5-(4-Chlorophenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione
CAS 878433-65-9C15H14ClN3O2S
5-(2,3-Dimethoxyphenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione chemical structure, C17H19N3O4S, CAS 878434-07-2
5-(2,3-Dimethoxyphenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione
CAS 878434-07-2C17H19N3O4S
5-(3-Methoxyphenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione chemical structure, C16H17N3O3S, CAS 878433-99-9
5-(3-Methoxyphenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione
CAS 878433-99-9C16H17N3O3S
5-(4-Hydroxyphenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione chemical structure, C15H15N3O3S, CAS 878434-34-5
5-(4-Hydroxyphenyl)-1-methyl-2-methylsulfanyl-6,8-dihydro-5H-pyrido[2,3-d]pyrimidine-4,7-dione
CAS 878434-34-5C15H15N3O3S
2-Amino-4-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one chemical structure, C14H14N4O4, CAS 878437-06-0
2-Amino-4-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
CAS 878437-06-0C14H14N4O4
2-Methylsulfanyl-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-dione chemical structure, C17H19N3O5S, CAS 878432-16-7
2-Methylsulfanyl-5-(2,3,4-trimethoxyphenyl)-1,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-dione
CAS 878432-16-7C17H19N3O5S
5-(3-Chlorophenyl)-2-(methylsulfanyl)-5,8-dihydropyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione chemical structure, C14H12ClN3O2S, CAS 727668-14-6
5-(3-Chlorophenyl)-2-(methylsulfanyl)-5,8-dihydropyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
CAS 727668-14-6C14H12ClN3O2S
2-Amino-5-(3-bromophenyl)-5,8-dihydropyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione chemical structure, C13H11BrN4O2, CAS 878436-17-0
2-Amino-5-(3-bromophenyl)-5,8-dihydropyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
CAS 878436-17-0C13H11BrN4O2
2-Amino-5-(2-fluorophenyl)-4-hydroxy-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one chemical structure, C13H11FN4O2, CAS 878436-01-2
2-Amino-5-(2-fluorophenyl)-4-hydroxy-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
CAS 878436-01-2C13H11FN4O2
2-Amino-5-(4-ethoxyphenyl)-4-hydroxy-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one chemical structure, C15H16N4O3, CAS 878436-90-9
2-Amino-5-(4-ethoxyphenyl)-4-hydroxy-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
CAS 878436-90-9C15H16N4O3
2-Amino-5-(4-ethylphenyl)-5,8-dihydropyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione chemical structure, C15H16N4O2, CAS 878437-09-3
2-Amino-5-(4-ethylphenyl)-5,8-dihydropyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione
CAS 878437-09-3C15H16N4O2
2-Amino-5-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidine-4,7-dione chemical structure, C17H18N4O4, CAS 878437-15-1
2-Amino-5-[3-methoxy-4-(prop-2-en-1-yloxy)phenyl]-3H,4H,5H,6H,7H,8H-pyrido[2,3-d]pyrimidine-4,7-dione
CAS 878437-15-1C17H18N4O4
2-Amino-5-(3-(trifluoromethoxy)phenyl)-3H,4H,5H,6H,7H,8H-pyrido(2,3-d)pyrimidine-4,7-dione chemical structure, C14H11F3N4O3, CAS 2305204-04-8
2-Amino-5-(3-(trifluoromethoxy)phenyl)-3H,4H,5H,6H,7H,8H-pyrido(2,3-d)pyrimidine-4,7-dione
CAS 2305204-04-8C14H11F3N4O3
2-Amino-5-(3-ethoxyphenyl)-3H,4H,5H,6H,7H,8H-pyrido(2,3-d)pyrimidine-4,7-dione chemical structure, C15H16N4O3, CAS 2305203-90-9
2-Amino-5-(3-ethoxyphenyl)-3H,4H,5H,6H,7H,8H-pyrido(2,3-d)pyrimidine-4,7-dione
CAS 2305203-90-9C15H16N4O3
5-(4-Methoxy-2-nitrophenyl)-2-propylsulfanyl-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-dione chemical structure, C17H18N4O5S, CAS 2549199-96-2
5-(4-Methoxy-2-nitrophenyl)-2-propylsulfanyl-3,5,6,8-tetrahydropyrido[2,3-d]pyrimidine-4,7-dione
CAS 2549199-96-2C17H18N4O5S