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Murcko scaffold

Ring system with 4 rings and 24 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
14
With full pages
2
Scaffold SMILES

O=C(Nc1ccccc1)c1cnc2c(-c3ccccc3)cnn2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cnc2c(-c3ccccc3)cnn2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

2,7-Dimethyl-N,3-diphenylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C21H18N4O, CAS 578002-58-1
2,7-Dimethyl-N,3-diphenylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 578002-58-1C21H18N4O
2,5-Dimethyl-N,3-diphenylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C21H18N4O, CAS 774561-16-9
2,5-Dimethyl-N,3-diphenylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 774561-16-9C21H18N4O
3-(4-Chlorophenyl)-2,5-dimethyl-N-(2-methylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C22H19ClN4O, CAS 774561-15-8
3-(4-Chlorophenyl)-2,5-dimethyl-N-(2-methylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 774561-15-8C22H19ClN4O
N-(4-Ethoxyphenyl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C23H22N4O2, CAS 876667-99-1
N-(4-Ethoxyphenyl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 876667-99-1C23H22N4O2
3-(4-Chlorophenyl)-N-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C22H19ClN4O2, CAS 882575-19-1
3-(4-Chlorophenyl)-N-(2-methoxyphenyl)-2,5-dimethylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 882575-19-1C22H19ClN4O2
3-(4-Fluorophenyl)-7-methyl-N-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C21H14F4N4O, CAS 1144431-33-3
3-(4-Fluorophenyl)-7-methyl-N-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1144431-33-3C21H14F4N4O
2-(Methoxymethyl)-7-methyl-3-phenyl-N-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C23H19F3N4O2, CAS 1158760-26-9
2-(Methoxymethyl)-7-methyl-3-phenyl-N-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158760-26-9C23H19F3N4O2
3-(4-Fluorophenyl)-2-(methoxymethyl)-7-methyl-N-phenylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C22H19FN4O2, CAS 1158195-68-6
3-(4-Fluorophenyl)-2-(methoxymethyl)-7-methyl-N-phenylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158195-68-6C22H19FN4O2
3-(4-Fluorophenyl)-2-(methoxymethyl)-N-(4-methoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C23H21FN4O3, CAS 1158334-07-6
3-(4-Fluorophenyl)-2-(methoxymethyl)-N-(4-methoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158334-07-6C23H21FN4O3
N-(3-Chlorophenyl)-3-(4-fluorophenyl)-2-(methoxymethyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C22H18ClFN4O2, CAS 1158588-38-5
N-(3-Chlorophenyl)-3-(4-fluorophenyl)-2-(methoxymethyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158588-38-5C22H18ClFN4O2
N-(2-Chlorophenyl)-3-(4-fluorophenyl)-2-(methoxymethyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C22H18ClFN4O2, CAS 1158274-39-5
N-(2-Chlorophenyl)-3-(4-fluorophenyl)-2-(methoxymethyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158274-39-5C22H18ClFN4O2
3-(4-Fluorophenyl)-2-(methoxymethyl)-N-(2-methoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C23H21FN4O3, CAS 1158227-52-1
3-(4-Fluorophenyl)-2-(methoxymethyl)-N-(2-methoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158227-52-1C23H21FN4O3
N-(5-Chloro-2-methoxyphenyl)-3-(4-fluorophenyl)-2-(methoxymethyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C23H20ClFN4O3, CAS 1158189-44-6
N-(5-Chloro-2-methoxyphenyl)-3-(4-fluorophenyl)-2-(methoxymethyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158189-44-6C23H20ClFN4O3
N-(3-Chloro-4-fluorophenyl)-2-(methoxymethyl)-3-(4-methoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C23H20ClFN4O3, CAS 1158235-71-2
N-(3-Chloro-4-fluorophenyl)-2-(methoxymethyl)-3-(4-methoxyphenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS 1158235-71-2C23H20ClFN4O3