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Murcko scaffold

8-Benzoyl-4-(benzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane scaffold

71 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
71
With full pages
3
Scaffold SMILES

O=C(c1ccccc1)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 8-Benzoyl-4-(benzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane page
Murcko scaffold O=C(c1ccccc1)N1CCC2(CC1)OCCN2S(=O)(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 71 chemicals

o-Tolyl(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C22H26N2O4S, CAS 896377-99-4
o-Tolyl(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 896377-99-4C22H26N2O4S
(2-Fluorophenyl)(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C21H23FN2O4S, CAS 896378-51-1
(2-Fluorophenyl)(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 896378-51-1C21H23FN2O4S
(3-Fluorophenyl)(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C21H23FN2O4S, CAS 896378-61-3
(3-Fluorophenyl)(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 896378-61-3C21H23FN2O4S
(4-Fluorophenyl)(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C21H23FN2O4S, CAS 896378-66-8
(4-Fluorophenyl)(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 896378-66-8C21H23FN2O4S
Phenyl(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C21H24N2O4S, CAS 896379-11-6
Phenyl(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 896379-11-6C21H24N2O4S
m-Tolyl(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C22H26N2O4S, CAS 896379-56-9
m-Tolyl(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 896379-56-9C22H26N2O4S
8-Benzoyl-4-(4-methoxybenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C21H24N2O5S, CAS 903254-82-0
8-Benzoyl-4-(4-methoxybenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 903254-82-0C21H24N2O5S
4-(Benzenesulfonyl)-8-(2-methoxybenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C21H24N2O5S, CAS 903256-25-7
4-(Benzenesulfonyl)-8-(2-methoxybenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 903256-25-7C21H24N2O5S
4-(Benzenesulfonyl)-8-(3-methoxybenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C21H24N2O5S, CAS 896363-06-7
4-(Benzenesulfonyl)-8-(3-methoxybenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 896363-06-7C21H24N2O5S
8-Benzoyl-4-(benzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C20H22N2O4S, CAS 896363-35-2
8-Benzoyl-4-(benzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 896363-35-2C20H22N2O4S
8-(4-Chlorobenzoyl)-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C20H21ClN2O4S, CAS 896363-40-9
8-(4-Chlorobenzoyl)-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 896363-40-9C20H21ClN2O4S
8-(2-Chlorobenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C21H22ClFN2O4S, CAS 923156-16-5
8-(2-Chlorobenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 923156-16-5C21H22ClFN2O4S
(2-Chloro-6-fluorophenyl)(4-((4-fluoro-3-methylphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C21H21ClF2N2O4S, CAS 923157-36-2
(2-Chloro-6-fluorophenyl)(4-((4-fluoro-3-methylphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 923157-36-2C21H21ClF2N2O4S
(2,6-Difluorophenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C21H22F2N2O5S, CAS 903254-46-6
(2,6-Difluorophenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 903254-46-6C21H22F2N2O5S
(2-Methoxyphenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C22H26N2O6S, CAS 898408-12-3
(2-Methoxyphenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 898408-12-3C22H26N2O6S
(4-Ethoxyphenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C23H28N2O6S, CAS 903254-75-1
(4-Ethoxyphenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 903254-75-1C23H28N2O6S
(4-Bromophenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone chemical structure, C21H23BrN2O5S, CAS 903255-21-0
(4-Bromophenyl)(4-((4-methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)methanone
CAS 903255-21-0C21H23BrN2O5S
(4-((4-Chlorophenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)(2-methyl-3-nitrophenyl)methanone chemical structure, C21H22ClN3O6S, CAS 941899-71-4
(4-((4-Chlorophenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)(2-methyl-3-nitrophenyl)methanone
CAS 941899-71-4C21H22ClN3O6S
(4-((4-Chlorophenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)(3-methyl-4-nitrophenyl)methanone chemical structure, C21H22ClN3O6S, CAS 897620-04-1
(4-((4-Chlorophenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)(3-methyl-4-nitrophenyl)methanone
CAS 897620-04-1C21H22ClN3O6S
4-(4-Chlorobenzenesulfonyl)-8-(2,4-dimethoxybenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C22H25ClN2O6S, CAS 923211-86-3
4-(4-Chlorobenzenesulfonyl)-8-(2,4-dimethoxybenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 923211-86-3C22H25ClN2O6S
8-(3,5-Dimethoxybenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C23H27FN2O6S, CAS 923691-20-7
8-(3,5-Dimethoxybenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 923691-20-7C23H27FN2O6S
8-(5-Chloro-2-methoxybenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C22H24ClFN2O5S, CAS 923212-27-5
8-(5-Chloro-2-methoxybenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 923212-27-5C22H24ClFN2O5S
4-(4-Fluoro-3-methylbenzenesulfonyl)-8-[2-(trifluoromethyl)benzoyl]-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C22H22F4N2O4S, CAS 923257-10-7
4-(4-Fluoro-3-methylbenzenesulfonyl)-8-[2-(trifluoromethyl)benzoyl]-1-oxa-4,8-diazaspiro[4.5]decane
CAS 923257-10-7C22H22F4N2O4S
8-(2-Bromobenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C21H22BrFN2O4S, CAS 923157-82-8
8-(2-Bromobenzoyl)-4-(4-fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 923157-82-8C21H22BrFN2O4S