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Murcko scaffold

Ring system with 4 rings and 27 atoms

21 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 27
Chemicals: 21
With full pages: 1

Scaffold SMILES

O=C(C=Cc1ccccc1)c1c(-c2ccccc2)c2ccccc2[nH]c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)c1c(-c2ccccc2)c2ccccc2[nH]c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

Ceranib 1 chemical structure, C26H21NO3

C₂₆H₂₁NO₃

6-Bromo-3-[(E)-3-(3-nitrophenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one chemical structure, C24H15BrN2O4, CAS 5509-44-4

6-Bromo-3-[(E)-3-(3-nitrophenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one

CAS 5509-44-4C₂₄H₁₅BrN₂O₄

6-Chloro-4-phenyl-3-[3-(3,4,5-trimethoxy-phenyl)-acryloyl]-1H-quinolin-2-one chemical structure, C27H22ClNO5, CAS 1564281-08-8

6-Chloro-4-phenyl-3-[3-(3,4,5-trimethoxy-phenyl)-acryloyl]-1H-quinolin-2-one

CAS 1564281-08-8C₂₇H₂₂ClNO₅

(E)-6-Bromo-3-(3-(2-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one chemical structure, C25H18BrNO3, CAS 1321862-87-6

(E)-6-Bromo-3-(3-(2-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one

CAS 1321862-87-6C₂₅H₁₈BrNO₃

3-[(Z)-3-(2,4-Dimethoxyphenyl)prop-2-enoyl]-6-methyl-4-phenyl-1H-quinolin-2-one chemical structure, C27H23NO4, CAS 333767-02-5

3-[(Z)-3-(2,4-Dimethoxyphenyl)prop-2-enoyl]-6-methyl-4-phenyl-1H-quinolin-2-one

CAS 333767-02-5C₂₇H₂₃NO₄

(E)-3-(3-(2-Fluorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one chemical structure, C24H16FNO2, CAS 5967-14-6

(E)-3-(3-(2-Fluorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one

CAS 5967-14-6C₂₄H₁₆FNO₂

(E)-6-Chloro-3-(3-(2-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one chemical structure, C25H18ClNO3, CAS 139781-19-4

(E)-6-Chloro-3-(3-(2-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one

CAS 139781-19-4C₂₅H₁₈ClNO₃

(E)-6-Bromo-3-(3-(2-fluorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one chemical structure, C24H15BrFNO2, CAS 392327-09-2

(E)-6-Bromo-3-(3-(2-fluorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one

CAS 392327-09-2C₂₄H₁₅BrFNO₂

(E)-3-(3-(3-Bromo-4,5-dimethoxyphenyl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one chemical structure, C26H19BrClNO4, CAS 392252-64-1

(E)-3-(3-(3-Bromo-4,5-dimethoxyphenyl)acryloyl)-6-chloro-4-phenylquinolin-2(1H)-one

CAS 392252-64-1C₂₆H₁₉BrClNO₄

(E)-6-Bromo-3-(3-(2,5-dimethoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one chemical structure, C26H20BrNO4, CAS 392252-55-0

(E)-6-Bromo-3-(3-(2,5-dimethoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one

CAS 392252-55-0C₂₆H₂₀BrNO₄

(E)-6-Chloro-3-(3-(2-chlorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one chemical structure, C24H15Cl2NO2, CAS 379716-80-0

(E)-6-Chloro-3-(3-(2-chlorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one

CAS 379716-80-0C₂₄H₁₅Cl₂NO₂

(2E)-1-[6-Bromo-4-(2-chlorophenyl)-2-hydroxyquinolin-3-yl]-3-(2-methoxyphenyl)prop-2-en-1-one chemical structure, C25H17BrClNO3, CAS 139781-21-8

(2E)-1-[6-Bromo-4-(2-chlorophenyl)-2-hydroxyquinolin-3-yl]-3-(2-methoxyphenyl)prop-2-en-1-one

CAS 139781-21-8C₂₅H₁₇BrClNO₃

(Z)-6-Methyl-4-phenyl-3-(3-phenylacryloyl)quinolin-2(1H)-one chemical structure, C25H19NO2, CAS 6049-42-9

(Z)-6-Methyl-4-phenyl-3-(3-phenylacryloyl)quinolin-2(1H)-one

CAS 6049-42-9C₂₅H₁₉NO₂

(E)-3-(3-(2-Fluorophenyl)acryloyl)-6-methyl-4-phenylquinolin-2(1H)-one chemical structure, C25H18FNO2, CAS 332898-61-0

(E)-3-(3-(2-Fluorophenyl)acryloyl)-6-methyl-4-phenylquinolin-2(1H)-one

CAS 332898-61-0C₂₅H₁₈FNO₂

6-Chloro-3-[3-(3-nitro-phenyl)-acryloyl]-4-phenyl-1H-quinolin-2-one chemical structure, C24H15ClN2O4, CAS 299418-99-8

6-Chloro-3-[3-(3-nitro-phenyl)-acryloyl]-4-phenyl-1H-quinolin-2-one

CAS 299418-99-8C₂₄H₁₅ClN₂O₄

(E)-6-Bromo-4-(2-chlorophenyl)-3-(3-(4-methoxyphenyl)acryloyl)quinolin-2(1H)-one chemical structure, C25H17BrClNO3, CAS 1321831-10-0

(E)-6-Bromo-4-(2-chlorophenyl)-3-(3-(4-methoxyphenyl)acryloyl)quinolin-2(1H)-one

CAS 1321831-10-0C₂₅H₁₇BrClNO₃

Ceranib1 chemical structure, C26H21NO3, CAS 328076-61-5

CAS 328076-61-5C₂₆H₂₁NO₃

6-Chloro-3-[3-(2,3-dimethoxy-phenyl)-acryloyl]-4-phenyl-1H-quinolin-2-one chemical structure, C26H20ClNO4, CAS 1564281-07-7

6-Chloro-3-[3-(2,3-dimethoxy-phenyl)-acryloyl]-4-phenyl-1H-quinolin-2-one

CAS 1564281-07-7C₂₆H₂₀ClNO₄

(E)-6-Chloro-3-(3-(2,4-dichlorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one chemical structure, C24H14Cl3NO2, CAS 392238-70-9

(E)-6-Chloro-3-(3-(2,4-dichlorophenyl)acryloyl)-4-phenylquinolin-2(1H)-one

CAS 392238-70-9C₂₄H₁₄Cl₃NO₂

1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one chemical structure, C26H20ClNO4, CAS 329786-68-7

1-(6-Chloro-2-hydroxy-4-phenylquinolin-3-yl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one

CAS 329786-68-7C₂₆H₂₀ClNO₄

Ceranib-2 chemical structure, C25H19NO3, CAS 1402830-75-4

CAS 1402830-75-4C₂₅H₁₉NO₃