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Murcko scaffold

3-Oxotetrahydrofuran scaffold

154 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
6
Chemicals
154
With full pages
6
Scaffold SMILES

O=C1CCOC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the 3-Oxotetrahydrofuran page
Murcko scaffold O=C1CCOC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 154 chemicals

Dihydro-2-methyl-3(2H)-furanone chemical structure, C5H8O2, CAS 3188-00-9
Dihydro-2-methyl-3(2H)-furanone
CAS 3188-00-9C5H8O2
3(2H)-Furanone, dihydro-2,5-diethyl-2,5-dimethyl- chemical structure, C10H18O2, CAS 18063-89-3
3(2H)-Furanone, dihydro-2,5-diethyl-2,5-dimethyl-
CAS 18063-89-3C10H18O2
3(2H)-Furanone, dihydro-5,5-bis(trifluoromethyl)-2-hydroxy-2-methyl- chemical structure, C7H6F6O3, CAS 101833-11-8
3(2H)-Furanone, dihydro-5,5-bis(trifluoromethyl)-2-hydroxy-2-methyl-
CAS 101833-11-8C7H6F6O3
Methyl tetrahydro-5-methyl-4-oxo-3-furoate chemical structure, C7H10O4, CAS 3210-57-9
Methyl tetrahydro-5-methyl-4-oxo-3-furoate
CAS 3210-57-9C7H10O4
Dihydro-2,5-dimethylfuran-3(2H)-one chemical structure, C6H10O2, CAS 64026-45-5
Dihydro-2,5-dimethylfuran-3(2H)-one
CAS 64026-45-5C6H10O2
3(2H)-Furanone, 5-acetyldihydro-2-hydroxy-2,5-dimethyl- chemical structure, C8H12O4, CAS 29549-78-8
3(2H)-Furanone, 5-acetyldihydro-2-hydroxy-2,5-dimethyl-
CAS 29549-78-8C8H12O4
2,2,5,5-Tetramethyltetrahydro-3-ketofuran chemical structure, C8H14O2, CAS 5455-94-7
2,2,5,5-Tetramethyltetrahydro-3-ketofuran
CAS 5455-94-7C8H14O2
2,5-Anhydro-1,4,6-trideoxy-6-(trimethylazaniumyl)hex-3-ulose iodide chemical structure, C9H18INO2, CAS 7524-73-4
2,5-Anhydro-1,4,6-trideoxy-6-(trimethylazaniumyl)hex-3-ulose iodide
CAS 7524-73-4C9H18INO2
Muscarone chemical structure, C9H18NO2+, CAS 13552-60-8
Muscarone
CAS 13552-60-8C9H18NO2+
Methyl 2-methyl-4-oxotetrahydrofuran-3-carboxylate chemical structure, C7H10O4, CAS 89898-49-7
Methyl 2-methyl-4-oxotetrahydrofuran-3-carboxylate
CAS 89898-49-7C7H10O4
5-Methyloxolan-3-one chemical structure, C5H8O2, CAS 34003-72-0
5-Methyloxolan-3-one
CAS 34003-72-0C5H8O2
3-Oxotetrahydrofuran chemical structure, C4H6O2, CAS 22929-52-8
3-Oxotetrahydrofuran
CAS 22929-52-8C4H6O2
3(2H)-Furanone, dihydro-5-isopropyl- chemical structure, C7H12O2, CAS 34004-69-8
3(2H)-Furanone, dihydro-5-isopropyl-
CAS 34004-69-8C7H12O2
2-tert-Butyl-5-hydroxy-2-methyl-5-(1,1,2,2-tetrafluoroethyl)oxolan-3-one chemical structure, C11H16F4O3, CAS 6002-58-0
2-tert-Butyl-5-hydroxy-2-methyl-5-(1,1,2,2-tetrafluoroethyl)oxolan-3-one
CAS 6002-58-0C11H16F4O3
2-tert-Butyl-5-hydroxy-2-methyl-5-(trifluoromethyl)oxolan-3-one chemical structure, C10H15F3O3, CAS 328285-40-1
2-tert-Butyl-5-hydroxy-2-methyl-5-(trifluoromethyl)oxolan-3-one
CAS 328285-40-1C10H15F3O3
Altenin chemical structure, C9H14O6, CAS 13912-19-1
Altenin
CAS 13912-19-1C9H14O6
4,5-Dihydro-2-methyl-3(2H)-furanone chemical structure, C6H10O2, CAS 90238-77-0
4,5-Dihydro-2-methyl-3(2H)-furanone
CAS 90238-77-0C6H10O2
(2S)-2-Methyloxolan-3-one chemical structure, C5H8O2, CAS 159651-26-0
(2S)-2-Methyloxolan-3-one
CAS 159651-26-0C5H8O2
(2S,4S)-2-Methyl-2,4-dihydroxydihydrofuran-3-one chemical structure, C5H8O4, CAS 406681-75-2
(2S,4S)-2-Methyl-2,4-dihydroxydihydrofuran-3-one
CAS 406681-75-2C5H8O4
4-Bromo-dihydro-furan-3-one chemical structure, C4H5BrO2, CAS 204926-50-1
4-Bromo-dihydro-furan-3-one
CAS 204926-50-1C4H5BrO2
4,4-Dimethyloxolan-3-one chemical structure, C6H10O2, CAS 15833-84-8
4,4-Dimethyloxolan-3-one
CAS 15833-84-8C6H10O2
tert-Butyl 4-oxooxolane-3-carboxylate chemical structure, C9H14O4, CAS 797038-32-5
tert-Butyl 4-oxooxolane-3-carboxylate
CAS 797038-32-5C9H14O4
Methyl 3-oxotetrahydrofuran-2-carboxylate chemical structure, C6H8O4, CAS 99017-83-1
Methyl 3-oxotetrahydrofuran-2-carboxylate
CAS 99017-83-1C6H8O4
2,2,5-Trimethyldihydro-3(2H)-furanone chemical structure, C7H12O2, CAS 34003-73-1
2,2,5-Trimethyldihydro-3(2H)-furanone
CAS 34003-73-1C7H12O2