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Murcko scaffold

EM-255 scaffold

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
15
With full pages
0
Scaffold SMILES

O=C1NCCCC1N1Cc2ccccc2C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the EM-255 page
Murcko scaffold O=C1NCCCC1N1Cc2ccccc2C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

EM-255 chemical structure, C13H14N2O2, CAS 79458-80-3
EM-255
CAS 79458-80-3C13H14N2O2
5-Bromo-2-(2-oxo-3-piperidyl)isoindolin-1-one chemical structure, C13H13BrN2O2, CAS 2845126-11-4
5-Bromo-2-(2-oxo-3-piperidyl)isoindolin-1-one
CAS 2845126-11-4C13H13BrN2O2
4-Amino-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one chemical structure, C14H14F3N3O2, CAS 2408961-94-2
4-Amino-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one
CAS 2408961-94-2C14H14F3N3O2
rac-4-Amino-2-[(3R,6R)-2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one chemical structure, C14H14F3N3O2, CAS 2408938-46-3
rac-4-Amino-2-[(3R,6R)-2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one
CAS 2408938-46-3C14H14F3N3O2
(S)-5-Fluoro-2-(2-oxopiperidin-3-yl)isoindolin-1-one chemical structure, C13H13FN2O2, CAS 2845095-68-1
(S)-5-Fluoro-2-(2-oxopiperidin-3-yl)isoindolin-1-one
CAS 2845095-68-1C13H13FN2O2
5-Amino-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one chemical structure, C14H14F3N3O2, CAS 2870642-14-9
5-Amino-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one
CAS 2870642-14-9C14H14F3N3O2
3-Oxo-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindole-5-carboxylic acid chemical structure, C15H13F3N2O4, CAS 2870644-65-6
3-Oxo-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindole-5-carboxylic acid
CAS 2870644-65-6C15H13F3N2O4
5-(Aminomethyl)-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one chemical structure, C15H16F3N3O2, CAS 2870643-25-5
5-(Aminomethyl)-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one
CAS 2870643-25-5C15H16F3N3O2
1-Oxo-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindole-4-carboxylic acid chemical structure, C15H13F3N2O4, CAS 2870643-51-7
1-Oxo-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindole-4-carboxylic acid
CAS 2870643-51-7C15H13F3N2O4
6-(Aminomethyl)-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one chemical structure, C15H16F3N3O2, CAS 2870642-71-8
6-(Aminomethyl)-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one
CAS 2870642-71-8C15H16F3N3O2
6-Amino-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one chemical structure, C14H14F3N3O2, CAS 2870643-58-4
6-Amino-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one
CAS 2870643-58-4C14H14F3N3O2
1-Oxo-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindole-5-carboxylic acid chemical structure, C15H13F3N2O4, CAS 2870642-77-4
1-Oxo-2-[2-oxo-6-(trifluoromethyl)piperidin-3-yl]-2,3-dihydro-1H-isoindole-5-carboxylic acid
CAS 2870642-77-4C15H13F3N2O4
4-Amino-2-[(3S,5R)-5-fluoro-2-oxopiperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one chemical structure, C13H14FN3O2, CAS 2947380-55-2
4-Amino-2-[(3S,5R)-5-fluoro-2-oxopiperidin-3-yl]-2,3-dihydro-1H-isoindol-1-one
CAS 2947380-55-2C13H14FN3O2
4-Amino-2-[(3S,5S)-5-fluoro-2-oxopiperidin-3-yl]-3H-isoindol-1-one chemical structure, C13H14FN3O2, CAS 2947380-27-8
4-Amino-2-[(3S,5S)-5-fluoro-2-oxopiperidin-3-yl]-3H-isoindol-1-one
CAS 2947380-27-8C13H14FN3O2
5-Amino-2-((3S,5S)-5-fluoro-2-oxopiperidin-3-yl)isoindolin-1-one chemical structure, C13H14FN3O2, CAS 2924073-95-8
5-Amino-2-((3S,5S)-5-fluoro-2-oxopiperidin-3-yl)isoindolin-1-one
CAS 2924073-95-8C13H14FN3O2