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Murcko scaffold

Thalidomide scaffold

1,722 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
1,722
With full pages
72
Scaffold SMILES

O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Thalidomide page
Murcko scaffold O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 1,722 chemicals

Thalidomide chemical structure, C13H10N2O4, CAS 50-35-1
Thalidomide
CAS 50-35-1C13H10N2O4
(R)-Thalidomide chemical structure, C13H10N2O4, CAS 2614-06-4
(R)-Thalidomide
CAS 2614-06-4C13H10N2O4
(S)-Thalidomide chemical structure, C13H10N2O4, CAS 841-67-8
(S)-Thalidomide
CAS 841-67-8C13H10N2O4
N-Methylthalidomide chemical structure, C14H12N2O4, CAS 42472-93-5
N-Methylthalidomide
CAS 42472-93-5C14H12N2O4
N-Hydroxythalidomide chemical structure, C13H10N2O5, CAS 126663-38-5
N-Hydroxythalidomide
CAS 126663-38-5C13H10N2O5
4-Nitrothalidomide chemical structure, C13H9N3O6, CAS 19171-18-7
4-Nitrothalidomide
CAS 19171-18-7C13H9N3O6
Pomalidomide chemical structure, C13H11N3O4, CAS 19171-19-8
Pomalidomide
CAS 19171-19-8C13H11N3O4
1H-Isoindole-1,3(2H)-dione, 2-(3-methyl-2,6-dioxo-3-piperidinyl)-, (R)- chemical structure, C14H12N2O4, CAS 108816-41-7
1H-Isoindole-1,3(2H)-dione, 2-(3-methyl-2,6-dioxo-3-piperidinyl)-, (R)-
CAS 108816-41-7C14H12N2O4
2-(3-Methyl-2,6-dioxo-piperidin-3-yl)-isoindole-1,3-dione chemical structure, C14H12N2O4, CAS 162662-87-5
2-(3-Methyl-2,6-dioxo-piperidin-3-yl)-isoindole-1,3-dione
CAS 162662-87-5C14H12N2O4
2-(2,6-Dioxopiperidin-3-yl)-4,5,6,7-tetrafluoro-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C13H6F4N2O4, CAS 179033-21-7
2-(2,6-Dioxopiperidin-3-yl)-4,5,6,7-tetrafluoro-2,3-dihydro-1H-isoindole-1,3-dione
CAS 179033-21-7C13H6F4N2O4
5-Hydroxythalidomide chemical structure, C13H10N2O5, CAS 64567-60-8
5-Hydroxythalidomide
CAS 64567-60-8C13H10N2O5
1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-5-aminoisoindoline chemical structure, C13H11N3O4, CAS 191732-76-0
1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-5-aminoisoindoline
CAS 191732-76-0C13H11N3O4
4-Methoxy-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione chemical structure, C14H12N2O5, CAS 244057-34-9
4-Methoxy-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione
CAS 244057-34-9C14H12N2O5
2-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide chemical structure, C15H14N4O5, CAS 444289-11-6
2-Amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)acetamide
CAS 444289-11-6C15H14N4O5
2-(2,6-Dioxopiperidin-3-yl)-4-methylisoindoline-1,3-dione chemical structure, C14H12N2O4, CAS 244057-31-6
2-(2,6-Dioxopiperidin-3-yl)-4-methylisoindoline-1,3-dione
CAS 244057-31-6C14H12N2O4
1H-Isoindole-1,3(2H)-dione, 2-(5-hydroxy-2,6-dioxo-3-piperidinyl)- chemical structure, C13H10N2O5, CAS 222991-42-6
1H-Isoindole-1,3(2H)-dione, 2-(5-hydroxy-2,6-dioxo-3-piperidinyl)-
CAS 222991-42-6C13H10N2O5
1,3-Dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindoline chemical structure, C13H9FN2O4, CAS 220460-55-9
1,3-Dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindoline
CAS 220460-55-9C13H9FN2O4
4-Amino-2-(3-fluoro-2,6-dioxo-3-piperidyl)isoindoline-1,3-dione chemical structure, C13H10FN3O4, CAS 220460-56-0
4-Amino-2-(3-fluoro-2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
CAS 220460-56-0C13H10FN3O4
4-Dimethylamino-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione chemical structure, C15H15N3O4, CAS 244057-35-0
4-Dimethylamino-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione
CAS 244057-35-0C15H15N3O4
Cps-11 chemical structure, C14H12N2O5, CAS 145945-21-7
Cps-11
CAS 145945-21-7C14H12N2O5
N-[2-(2,6-Dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl]propanamide chemical structure, C16H15N3O5, CAS 444287-80-3
N-[2-(2,6-Dioxo(3-piperidyl))-1,3-dioxoisoindolin-4-yl]propanamide
CAS 444287-80-3C16H15N3O5
2-(2,6-Dioxo-3-piperidyl)-4-(pentylamino)isoindoline-1,3-dione chemical structure, C18H21N3O4, CAS 444287-97-2
2-(2,6-Dioxo-3-piperidyl)-4-(pentylamino)isoindoline-1,3-dione
CAS 444287-97-2C18H21N3O4
N-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]-2-methoxy-acetamide chemical structure, C16H15N3O6, CAS 444287-72-3
N-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]-2-methoxy-acetamide
CAS 444287-72-3C16H15N3O6
2-(2,6-Dioxopiperid-3-yl)-4,7-dimethylisoindoline-1,3-dione chemical structure, C15H14N2O4, CAS 244057-32-7
2-(2,6-Dioxopiperid-3-yl)-4,7-dimethylisoindoline-1,3-dione
CAS 244057-32-7C15H14N2O4