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Murcko scaffold

3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione scaffold

1,269 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
1,269
With full pages
47
Scaffold SMILES

O=C1CCC(N2Cc3ccccc3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione page
Murcko scaffold O=C1CCC(N2Cc3ccccc3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 1,269 chemicals

3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione chemical structure, C13H12N2O3, CAS 26581-81-7
3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
CAS 26581-81-7C13H12N2O3
2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, (S)- chemical structure, C13H12N2O3, CAS 107657-57-8
2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, (S)-
CAS 107657-57-8C13H12N2O3
(R)-3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione chemical structure, C13H12N2O3, CAS 107740-48-7
(R)-3-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
CAS 107740-48-7C13H12N2O3
Lenalidomide chemical structure, C13H13N3O3, CAS 191732-72-6
Lenalidomide
CAS 191732-72-6C13H13N3O3
3-(4-Methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione chemical structure, C14H14N2O3, CAS 886360-12-9
3-(4-Methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS 886360-12-9C14H14N2O3
3-(5-Amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione chemical structure, C13H13N3O3, CAS 191732-70-4
3-(5-Amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
CAS 191732-70-4C13H13N3O3
3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-fluoro-2,6-piperidinedione chemical structure, C13H12FN3O3, CAS 220460-64-0
3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-fluoro-2,6-piperidinedione
CAS 220460-64-0C13H12FN3O3
2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-fluoro- chemical structure, C13H11FN2O3, CAS 220460-63-9
2,6-Piperidinedione, 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-3-fluoro-
CAS 220460-63-9C13H11FN2O3
3-[1-Oxo-4-(pentylamino)isoindolin-2-yl]piperidine-2,6-dione chemical structure, C18H23N3O3, CAS 444287-91-6
3-[1-Oxo-4-(pentylamino)isoindolin-2-yl]piperidine-2,6-dione
CAS 444287-91-6C18H23N3O3
2-Amino-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]acetamide chemical structure, C15H16N4O4, CAS 444289-12-7
2-Amino-N-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]acetamide
CAS 444289-12-7C15H16N4O4
2-Chloro-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]acetamide chemical structure, C15H14ClN3O4, CAS 444287-87-0
2-Chloro-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]acetamide
CAS 444287-87-0C15H14ClN3O4
3-(5-Amino-1-oxo-isoindolin-2-yl)-3-fluoro-piperidine-2,6-dione chemical structure, C13H12FN3O3, CAS 220460-62-8
3-(5-Amino-1-oxo-isoindolin-2-yl)-3-fluoro-piperidine-2,6-dione
CAS 220460-62-8C13H12FN3O3
3-(6-Amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione chemical structure, C13H13N3O3, CAS 191732-74-8
3-(6-Amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
CAS 191732-74-8C13H13N3O3
2-Azido-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl)acetamide chemical structure, C15H14N6O4, CAS 444287-88-1
2-Azido-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl)acetamide
CAS 444287-88-1C15H14N6O4
3-Hydroxy-2-(2,6-dioxopiperidine-3-yl)isoindoline-1-one chemical structure, C13H12N2O4, CAS 58585-25-4
3-Hydroxy-2-(2,6-dioxopiperidine-3-yl)isoindoline-1-one
CAS 58585-25-4C13H12N2O4
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione chemical structure, C13H11N3O5, CAS 827026-45-9
3-(4-Nitro-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
CAS 827026-45-9C13H11N3O5
Lenalidomide, (S)- chemical structure, C13H13N3O3, CAS 202271-91-8
Lenalidomide, (S)-
CAS 202271-91-8C13H13N3O3
1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline chemical structure, C13H8F4N2O3, CAS 202271-86-1
1-Oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline
CAS 202271-86-1C13H8F4N2O3
tert-Butyl ((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)carbamate chemical structure, C19H23N3O5, CAS 927670-62-0
tert-Butyl ((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)carbamate
CAS 927670-62-0C19H23N3O5
N-[2-(2,6-Dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]pentanamide chemical structure, C18H21N3O4, CAS 444289-18-3
N-[2-(2,6-Dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]pentanamide
CAS 444289-18-3C18H21N3O4
tert-Butyl 3-(4-methyl-1-oxoisoindolin-2-yl)-2,6-dioxopiperidine-1-carboxylate chemical structure, C19H22N2O5, CAS 1245355-94-5
tert-Butyl 3-(4-methyl-1-oxoisoindolin-2-yl)-2,6-dioxopiperidine-1-carboxylate
CAS 1245355-94-5C19H22N2O5
3-(5-Methyl-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione chemical structure, C14H14N2O3, CAS 1416990-03-8
3-(5-Methyl-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
CAS 1416990-03-8C14H14N2O3
3-(1,3-Dihydro-4,5,6,7-tetramethyl-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione chemical structure, C17H20N2O3, CAS 1198787-20-0
3-(1,3-Dihydro-4,5,6,7-tetramethyl-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
CAS 1198787-20-0C17H20N2O3
3-(7-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione chemical structure, C13H13N3O3, CAS 191732-75-9
3-(7-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
CAS 191732-75-9C13H13N3O3