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Murcko scaffold

Ring system with 4 rings and 25 atoms

65 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
65
With full pages
13
Scaffold SMILES

C(=NN1CCN(Cc2cccc3ccccc23)CC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=NN1CCN(Cc2cccc3ccccc23)CC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

N-(1-(2,4-Dichlorophenyl)ethylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C23H23Cl2N3, CAS 315224-65-8
N-(1-(2,4-Dichlorophenyl)ethylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 315224-65-8C23H23Cl2N3
N-(4-Ethylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C24H27N3, CAS 306951-65-5
N-(4-Ethylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306951-65-5C24H27N3
N-(2,3-Dimethoxybenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C24H27N3O2, CAS 306951-80-4
N-(2,3-Dimethoxybenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306951-80-4C24H27N3O2
N-(2,4-Dichlorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C22H21Cl2N3, CAS 306952-15-8
N-(2,4-Dichlorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306952-15-8C22H21Cl2N3
N-[(E)-(2-Methoxyphenyl)methylidene]-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C23H25N3O, CAS 306952-23-8
N-[(E)-(2-Methoxyphenyl)methylidene]-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306952-23-8C23H25N3O
N-(2-Chlorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C22H22ClN3, CAS 306952-10-3
N-(2-Chlorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306952-10-3C22H22ClN3
N-(2,3-Dichlorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C22H21Cl2N3, CAS 306951-79-1
N-(2,3-Dichlorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306951-79-1C22H21Cl2N3
N-(2,4-Dimethoxybenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C24H27N3O2, CAS 306952-02-3
N-(2,4-Dimethoxybenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306952-02-3C24H27N3O2
N-(4-Methylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C23H25N3, CAS 306952-19-2
N-(4-Methylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306952-19-2C23H25N3
N-(4-Ethoxybenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C24H27N3O, CAS 306951-86-0
N-(4-Ethoxybenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306951-86-0C24H27N3O
N-(4-(Dimethylamino)benzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C24H28N4, CAS 5812-16-8
N-(4-(Dimethylamino)benzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 5812-16-8C24H28N4
N,N-Diethyl-4-[(E)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]iminomethyl]aniline chemical structure, C26H32N4, CAS 306952-21-6
N,N-Diethyl-4-[(E)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]iminomethyl]aniline
CAS 306952-21-6C26H32N4
4-(Naphthalen-1-ylmethyl)-N-[(E)-(4-nitrophenyl)methylidene]piperazin-1-amine chemical structure, C22H22N4O2, CAS 306952-25-0
4-(Naphthalen-1-ylmethyl)-N-[(E)-(4-nitrophenyl)methylidene]piperazin-1-amine
CAS 306952-25-0C22H22N4O2
[2,6-Dimethoxy-4-[(E)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]iminomethyl]phenyl] acetate chemical structure, C26H29N3O4, CAS 306951-96-2
[2,6-Dimethoxy-4-[(E)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]iminomethyl]phenyl] acetate
CAS 306951-96-2C26H29N3O4
N-(3-Bromobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C22H22BrN3, CAS 306951-62-2
N-(3-Bromobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306951-62-2C22H22BrN3
N-(4-Fluorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C22H22FN3, CAS 306951-85-9
N-(4-Fluorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 306951-85-9C22H22FN3
N-(2-Methylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C23H25N3, CAS 303102-35-4
N-(2-Methylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 303102-35-4C23H25N3
N-(2-Chloro-5-nitrobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C22H21ClN4O2, CAS 303102-36-5
N-(2-Chloro-5-nitrobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 303102-36-5C22H21ClN4O2
N-(3-Methylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C23H25N3, CAS 303102-38-7
N-(3-Methylbenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 303102-38-7C23H25N3
N-[(E)-(3-Methoxyphenyl)methylidene]-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C23H25N3O, CAS 315224-83-0
N-[(E)-(3-Methoxyphenyl)methylidene]-4-(1-naphthylmethyl)-1-piperazinamine
CAS 315224-83-0C23H25N3O
N-(3-Fluorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine chemical structure, C22H22FN3, CAS 303102-33-2
N-(3-Fluorobenzylidene)-4-(1-naphthylmethyl)-1-piperazinamine
CAS 303102-33-2C22H22FN3
4-(Naphthalen-1-ylmethyl)-N-[(E)-(4-propoxyphenyl)methylidene]piperazin-1-amine chemical structure, C25H29N3O, CAS 315224-85-2
4-(Naphthalen-1-ylmethyl)-N-[(E)-(4-propoxyphenyl)methylidene]piperazin-1-amine
CAS 315224-85-2C25H29N3O
4-[(E)-[4-(Naphthalen-1-ylmethyl)piperazin-1-yl]iminomethyl]benzoic acid chemical structure, C23H23N3O2, CAS 315224-81-8
4-[(E)-[4-(Naphthalen-1-ylmethyl)piperazin-1-yl]iminomethyl]benzoic acid
CAS 315224-81-8C23H23N3O2
N-[(E)-(3-Bromo-4-methoxyphenyl)methylidene]-4-(naphthalen-1-ylmethyl)piperazin-1-amine chemical structure, C23H24BrN3O, CAS 315225-01-5
N-[(E)-(3-Bromo-4-methoxyphenyl)methylidene]-4-(naphthalen-1-ylmethyl)piperazin-1-amine
CAS 315225-01-5C23H24BrN3O