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Murcko scaffold

Ring system with 4 rings and 25 atoms

17 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
17
With full pages
1
Scaffold SMILES

c1ccc(COc2ccc(Nc3ncnc4ccccc34)cc2)nc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(COc2ccc(Nc3ncnc4ccccc34)cc2)nc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

N-{2-[(4-{3-Chloro-4-(pyridin-2-ylmethoxy)anilino}quinazolin-5-yl)oxy]ethyl}acetamide chemical structure, C24H22ClN5O3, CAS 853000-33-6
N-{2-[(4-{3-Chloro-4-(pyridin-2-ylmethoxy)anilino}quinazolin-5-yl)oxy]ethyl}acetamide
CAS 853000-33-6C24H22ClN5O3
N-(2-(4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-5-yloxy)ethyl)-2-hydroxy-N-methylacetamide chemical structure, C25H24ClN5O4, CAS 853000-40-5
N-(2-(4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-5-yloxy)ethyl)-2-hydroxy-N-methylacetamide
CAS 853000-40-5C25H24ClN5O4
2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]acetamide chemical structure, C22H18ClN5O3, CAS 871018-52-9
2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]acetamide
CAS 871018-52-9C22H18ClN5O3
6,7-Dimethoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline chemical structure, C23H22N4O3, CAS 179688-83-6
6,7-Dimethoxy-4-[3-methyl-4-(pyridin-2-ylmethoxy)anilino]quinazoline
CAS 179688-83-6C23H22N4O3
6-Amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]quinazoline chemical structure, C20H16ClN5O, CAS 179688-74-5
6-Amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]quinazoline
CAS 179688-74-5C20H16ClN5O
N-[3-Chloro-4-(2-pyridylmethoxy)phenyl]-6-nitro-quinazolin-4-amine chemical structure, C20H14ClN5O3, CAS 179688-70-1
N-[3-Chloro-4-(2-pyridylmethoxy)phenyl]-6-nitro-quinazolin-4-amine
CAS 179688-70-1C20H14ClN5O3
N-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-fluoro-6-nitroquinazolin-4-amine chemical structure, C20H13ClFN5O3, CAS 897441-42-8
N-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-fluoro-6-nitroquinazolin-4-amine
CAS 897441-42-8C20H13ClFN5O3
N-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-methoxy-6-nitroquinazolin-4-amine chemical structure, C21H16ClN5O4, CAS 897384-03-1
N-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-methoxy-6-nitroquinazolin-4-amine
CAS 897384-03-1C21H16ClN5O4
4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-6-ol chemical structure, C20H15ClN4O2, CAS 848438-84-6
4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-6-ol
CAS 848438-84-6C20H15ClN4O2
N-[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-fluoroquinazolin-4-amine chemical structure, C20H14ClFN4O, CAS 524955-33-7
N-[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]-5-fluoroquinazolin-4-amine
CAS 524955-33-7C20H14ClFN4O
n4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-ethoxyquinazoline-4,6-diamine chemical structure, C22H20ClN5O2, CAS 897384-10-0
n4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-ethoxyquinazoline-4,6-diamine
CAS 897384-10-0C22H20ClN5O2
n4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-methoxyquinazoline-4,6-diamine chemical structure, C21H18ClN5O2, CAS 897025-65-9
n4-(3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)-7-methoxyquinazoline-4,6-diamine
CAS 897025-65-9C21H18ClN5O2
[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]acetic acid chemical structure, C22H17ClN4O4, CAS 871084-80-9
[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]acetic acid
CAS 871084-80-9C22H17ClN4O4
Ethyl [(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]acetate chemical structure, C24H21ClN4O4, CAS 871018-55-2
Ethyl [(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]acetate
CAS 871018-55-2C24H21ClN4O4
N-[3-Chloro-4-(2-pyridinylmethoxy)phenyl]-7-ethoxy-6-nitro-4-quinazolinamine chemical structure, C22H18ClN5O4, CAS 1637255-10-7
N-[3-Chloro-4-(2-pyridinylmethoxy)phenyl]-7-ethoxy-6-nitro-4-quinazolinamine
CAS 1637255-10-7C22H18ClN5O4
Egfr/her2-IN-5 chemical structure, C30H33ClN6O4, CAS 1879071-97-2
Egfr/her2-IN-5
CAS 1879071-97-2C30H33ClN6O4
4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-ol chemical structure, C20H15ClN4O2, CAS 786689-27-8
4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-ol
CAS 786689-27-8C20H15ClN4O2