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Murcko scaffold

1-Phenyl-4-(3-phenyl-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one scaffold

158 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 158
With full pages: 5

Scaffold SMILES

O=C1CC(c2nc(-c3ccccc3)no2)CN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-Phenyl-4-(3-phenyl-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one page

Murcko scaffold O=C1CC(c2nc(-c3ccccc3)no2)CN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 158 chemicals

1-Phenyl-4-(3-phenyl-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one chemical structure, C18H15N3O2, CAS 892682-66-5

1-Phenyl-4-(3-phenyl-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one

CAS 892682-66-5C₁₈H₁₅N₃O₂

4-[3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-phenylpyrrolidin-2-one chemical structure, C20H19N3O4, CAS 941997-51-9

4-[3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-phenylpyrrolidin-2-one

CAS 941997-51-9C₂₀H₁₉N₃O₄

4-[3-(2,3-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-(4-fluorophenyl)pyrrolidin-2-one chemical structure, C20H18FN3O4, CAS 941962-50-1

4-[3-(2,3-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-(4-fluorophenyl)pyrrolidin-2-one

CAS 941962-50-1C₂₀H₁₈FN₃O₄

1-(3-Chloro-4-methoxyphenyl)-4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one chemical structure, C20H18ClN3O3, CAS 941997-95-1

1-(3-Chloro-4-methoxyphenyl)-4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

CAS 941997-95-1C₂₀H₁₈ClN₃O₃

1-(3-Chloro-4-methoxyphenyl)-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one chemical structure, C22H22ClN3O6, CAS 941919-54-6

1-(3-Chloro-4-methoxyphenyl)-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

CAS 941919-54-6C₂₂H₂₂ClN₃O₆

1-(3,5-Dimethylphenyl)-4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one chemical structure, C21H21N3O2, CAS 942034-56-2

1-(3,5-Dimethylphenyl)-4-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

CAS 942034-56-2C₂₁H₂₁N₃O₂

4-(3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(3,5-dimethylphenyl)pyrrolidin-2-one chemical structure, C20H18ClN3O2, CAS 941912-89-6

4-(3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(3,5-dimethylphenyl)pyrrolidin-2-one

CAS 941912-89-6C₂₀H₁₈ClN₃O₂

1-(4-Ethoxyphenyl)-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one chemical structure, C23H25N3O6, CAS 941962-65-8

1-(4-Ethoxyphenyl)-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

CAS 941962-65-8C₂₃H₂₅N₃O₆

1-(2,5-Dimethylphenyl)-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one chemical structure, C23H25N3O5, CAS 946267-83-0

1-(2,5-Dimethylphenyl)-4-[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

CAS 946267-83-0C₂₃H₂₅N₃O₅

4-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(3-fluoro-4-methylphenyl)pyrrolidin-2-one chemical structure, C19H15ClFN3O2, CAS 941961-61-1

4-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(3-fluoro-4-methylphenyl)pyrrolidin-2-one

CAS 941961-61-1C₁₉H₁₅ClFN₃O₂

4-[3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-(3-fluoro-4-methylphenyl)pyrrolidin-2-one chemical structure, C21H20FN3O4, CAS 941998-29-4

4-[3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-(3-fluoro-4-methylphenyl)pyrrolidin-2-one

CAS 941998-29-4C₂₁H₂₀FN₃O₄

1-(3-Chloro-4-methylphenyl)-4-{3-[4-(dimethylamino)phenyl]-1,2,4-oxadiazol-5-YL}pyrrolidin-2-one chemical structure, C21H21ClN4O2, CAS 941893-40-9

1-(3-Chloro-4-methylphenyl)-4-{3-[4-(dimethylamino)phenyl]-1,2,4-oxadiazol-5-YL}pyrrolidin-2-one

CAS 941893-40-9C₂₁H₂₁ClN₄O₂

4-{3-[4-(Dimethylamino)phenyl]-1,2,4-oxadiazol-5-yl}-1-(3-fluoro-4-methylphenyl)pyrrolidin-2-one chemical structure, C21H21FN4O2, CAS 941893-52-3

4-{3-[4-(Dimethylamino)phenyl]-1,2,4-oxadiazol-5-yl}-1-(3-fluoro-4-methylphenyl)pyrrolidin-2-one

CAS 941893-52-3C₂₁H₂₁FN₄O₂

1-(4-Ethoxyphenyl)-4-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}pyrrolidin-2-one chemical structure, C21H18F3N3O3, CAS 941998-05-6

1-(4-Ethoxyphenyl)-4-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}pyrrolidin-2-one

CAS 941998-05-6C₂₁H₁₈F₃N₃O₃

1-(4-Ethylphenyl)-4-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one chemical structure, C20H18FN3O2, CAS 941961-40-6

1-(4-Ethylphenyl)-4-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

CAS 941961-40-6C₂₀H₁₈FN₃O₂

4-(3-Phenyl-1,2,4-oxadiazol-5-yl)-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one chemical structure, C21H21N3O2, CAS 941892-29-1

4-(3-Phenyl-1,2,4-oxadiazol-5-yl)-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one

CAS 941892-29-1C₂₁H₂₁N₃O₂

4-[3-(3-Methylphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one chemical structure, C22H23N3O2, CAS 941961-46-2

4-[3-(3-Methylphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one

CAS 941961-46-2C₂₂H₂₃N₃O₂

4-(3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(4-isopropylphenyl)pyrrolidin-2-one chemical structure, C21H20ClN3O2, CAS 941998-17-0

4-(3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(4-isopropylphenyl)pyrrolidin-2-one

CAS 941998-17-0C₂₁H₂₀ClN₃O₂

4-(3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(4-isopropylphenyl)pyrrolidin-2-one chemical structure, C21H20ClN3O2, CAS 941892-32-6

4-(3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(4-isopropylphenyl)pyrrolidin-2-one

CAS 941892-32-6C₂₁H₂₀ClN₃O₂

4-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one chemical structure, C22H23N3O3, CAS 941961-52-0

4-[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one

CAS 941961-52-0C₂₂H₂₃N₃O₃

1-(4-Isopropylphenyl)-4-(3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one chemical structure, C24H27N3O5, CAS 941998-21-6

1-(4-Isopropylphenyl)-4-(3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one

CAS 941998-21-6C₂₄H₂₇N₃O₅

4-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one chemical structure, C23H25N3O4, CAS 941892-38-2

4-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(propan-2-yl)phenyl]pyrrolidin-2-one

CAS 941892-38-2C₂₃H₂₅N₃O₄

4-(3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)-1-(4-isopropylphenyl)pyrrolidin-2-one chemical structure, C23H25N3O4, CAS 941918-23-6

4-(3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)-1-(4-isopropylphenyl)pyrrolidin-2-one

CAS 941918-23-6C₂₃H₂₅N₃O₄

1-(4-Isopropylphenyl)-4-(3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one chemical structure, C22H20F3N3O2, CAS 941998-23-8

1-(4-Isopropylphenyl)-4-(3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidin-2-one

CAS 941998-23-8C₂₂H₂₀F₃N₃O₂