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Murcko scaffold

Ring system with 4 rings and 23 atoms

89 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 89
With full pages: 3

Scaffold SMILES

N=C1C(c2nc(-c3ccccc3)cs2)=CCN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold N=C1C(c2nc(-c3ccccc3)cs2)=CCN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 89 chemicals

5-Amino-4-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C20H16ClN3O2S, CAS 380387-05-3

5-Amino-4-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 380387-05-3C₂₀H₁₆ClN₃O₂S

5-Amino-4-(4-(4-chlorophenyl)thiazol-2-yl)-1-(4-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C19H13ClFN3OS, CAS 885458-09-3

5-Amino-4-(4-(4-chlorophenyl)thiazol-2-yl)-1-(4-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 885458-09-3C₁₉H₁₃ClFN₃OS

5-Amino-4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-1-(4-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C21H18FN3O3S, CAS 885458-12-8

5-Amino-4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-1-(4-fluorophenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 885458-12-8C₂₁H₁₈FN₃O₃S

5-Amino-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-1-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C20H16FN3O2S, CAS 380470-04-2

5-Amino-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-1-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 380470-04-2C₂₀H₁₆FN₃O₂S

5-Amino-1-(4-chlorophenyl)-4-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1H-pyrrol-3-one chemical structure, C21H18ClN3O3S, CAS 885458-14-0

5-Amino-1-(4-chlorophenyl)-4-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1H-pyrrol-3-one

CAS 885458-14-0C₂₁H₁₈ClN₃O₃S

4-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-5-imino-1-phenyl-2,5-dihydro-1H-pyrrol-3-ol chemical structure, C19H14ClN3OS, CAS 380386-92-5

4-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-5-imino-1-phenyl-2,5-dihydro-1H-pyrrol-3-ol

CAS 380386-92-5C₁₉H₁₄ClN₃OS

5-Amino-1-(4-methoxyphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C20H17N3O2S, CAS 380387-80-4

5-Amino-1-(4-methoxyphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one

CAS 380387-80-4C₂₀H₁₇N₃O₂S

5-Amino-1-(4-chlorophenyl)-4-(4-(4-fluorophenyl)thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C19H13ClFN3OS, CAS 885458-18-4

5-Amino-1-(4-chlorophenyl)-4-(4-(4-fluorophenyl)thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one

CAS 885458-18-4C₁₉H₁₃ClFN₃OS

5-Amino-4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-1-(4-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C22H21N3O4S, CAS 885458-16-2

5-Amino-4-(4-(3,4-dimethoxyphenyl)thiazol-2-yl)-1-(4-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one

CAS 885458-16-2C₂₂H₂₁N₃O₄S

5-Amino-1-(4-chlorophenyl)-4-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1H-pyrrol-3-one chemical structure, C19H13Cl2N3OS, CAS 380387-91-7

5-Amino-1-(4-chlorophenyl)-4-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1H-pyrrol-3-one

CAS 380387-91-7C₁₉H₁₃Cl₂N₃OS

5-Amino-4-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]-1-phenyl-1,2-dihydro-3H-pyrrol-3-one chemical structure, C21H19N3O3S, CAS 885460-77-5

5-Amino-4-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]-1-phenyl-1,2-dihydro-3H-pyrrol-3-one

CAS 885460-77-5C₂₁H₁₉N₃O₃S

5-Amino-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-1-phenyl-2,3-dihydro-1H-pyrrol-3-one chemical structure, C19H14FN3OS, CAS 885460-78-6

5-Amino-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-1-phenyl-2,3-dihydro-1H-pyrrol-3-one

CAS 885460-78-6C₁₉H₁₄FN₃OS

5-Amino-1-(4-fluorophenyl)-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1H-pyrrol-3-one chemical structure, C19H13F2N3OS, CAS 885460-79-7

5-Amino-1-(4-fluorophenyl)-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-2,3-dihydro-1H-pyrrol-3-one

CAS 885460-79-7C₁₉H₁₃F₂N₃OS

5-Amino-1-(4-isopropylphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C22H21N3OS, CAS 380387-81-5

5-Amino-1-(4-isopropylphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one

CAS 380387-81-5C₂₂H₂₁N₃OS

5-Amino-4-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-1-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one chemical structure, C20H16ClN3O2S, CAS 380387-07-5

5-Amino-4-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-1-(4-methoxyphenyl)-2,3-dihydro-1H-pyrrol-3-one

CAS 380387-07-5C₂₀H₁₆ClN₃O₂S

5-Amino-1-(3-methoxyphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C20H17N3O2S, CAS 380386-88-9

5-Amino-1-(3-methoxyphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one

CAS 380386-88-9C₂₀H₁₇N₃O₂S

5-Amino-1-(3-chlorophenyl)-4-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]-1,2-dihydro-3H-pyrrol-3-one chemical structure, C21H18ClN3O3S, CAS 380446-30-0

5-Amino-1-(3-chlorophenyl)-4-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]-1,2-dihydro-3H-pyrrol-3-one

CAS 380446-30-0C₂₁H₁₈ClN₃O₃S

5-Imino-4-(4-phenyl-1,3-thiazol-2-yl)-1-(3,4,5-trifluorophenyl)-2,5-dihydro-1H-pyrrol-3-ol chemical structure, C19H12F3N3OS, CAS 1676087-06-1

5-Imino-4-(4-phenyl-1,3-thiazol-2-yl)-1-(3,4,5-trifluorophenyl)-2,5-dihydro-1H-pyrrol-3-ol

CAS 1676087-06-1C₁₉H₁₂F₃N₃OS

3-[4-Hydroxy-2-imino-3-(4-phenyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]-N-methylbenzamide chemical structure, C21H18N4O2S, CAS 1676074-43-3

3-[4-Hydroxy-2-imino-3-(4-phenyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]-N-methylbenzamide

CAS 1676074-43-3C₂₁H₁₈N₄O₂S

5-Imino-4-(4-phenyl-1,3-thiazol-2-yl)-1-[3-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-3-ol chemical structure, C20H14F3N3O2S, CAS 1676069-71-8

5-Imino-4-(4-phenyl-1,3-thiazol-2-yl)-1-[3-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-3-ol

CAS 1676069-71-8C₂₀H₁₄F₃N₃O₂S

3-[4-Hydroxy-2-imino-3-(4-phenyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methoxy-N-methylbenzamide chemical structure, C22H20N4O3S, CAS 1676068-37-3

3-[4-Hydroxy-2-imino-3-(4-phenyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]-4-methoxy-N-methylbenzamide

CAS 1676068-37-3C₂₂H₂₀N₄O₃S

Ethyl 3-[5-amino-3-oxo-4-(4-phenyl-1,3-thiazol-2-yl)-2,3-dihydro-1H-pyrrol-1-yl]benzoate chemical structure, C22H19N3O3S, CAS 951938-11-7

Ethyl 3-[5-amino-3-oxo-4-(4-phenyl-1,3-thiazol-2-yl)-2,3-dihydro-1H-pyrrol-1-yl]benzoate

CAS 951938-11-7C₂₂H₁₉N₃O₃S

5-Amino-1-(3,5-dimethoxyphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C21H19N3O3S, CAS 951993-67-2

5-Amino-1-(3,5-dimethoxyphenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one

CAS 951993-67-2C₂₁H₁₉N₃O₃S

5-Amino-1-(3-bromophenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C19H14BrN3OS, CAS 459127-60-7

5-Amino-1-(3-bromophenyl)-4-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one

CAS 459127-60-7C₁₉H₁₄BrN₃OS