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Murcko scaffold

Ring system with 4 rings and 28 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
9
With full pages
1
Scaffold SMILES

O=C1C(=O)N(CCCn2ccnc2)C(c2cccnc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(CCCn2ccnc2)C(c2cccnc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

4-(Hydroxyphenylmethylene)-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-pyridinyl)-2,3-pyrrolidinedione chemical structure, C22H20N4O3, CAS 898796-78-6
4-(Hydroxyphenylmethylene)-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-pyridinyl)-2,3-pyrrolidinedione
CAS 898796-78-6C22H20N4O3
4-(3-Ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H24N4O4, CAS 609317-23-9
4-(3-Ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 609317-23-9C24H24N4O4
4-(4-Chlorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H19ClN4O3, CAS 380167-80-6
4-(4-Chlorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 380167-80-6C22H19ClN4O3
4-Benzoyl-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H20N4O3, CAS 378776-06-8
4-Benzoyl-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 378776-06-8C22H20N4O3
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H22N4O3, CAS 378218-38-3
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 378218-38-3C23H22N4O3
(4E)-4-{Hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)pyrrolidine-2,3-dione chemical structure, C25H26N4O4, CAS 385420-49-5
(4E)-4-{Hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-3-yl)pyrrolidine-2,3-dione
CAS 385420-49-5C25H26N4O4
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24N4O4, CAS 615271-05-1
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 615271-05-1C25H24N4O4
4-(2,5-Dimethyl-benzoyl)-3-hydroxy-1-(3-imidazol-1-yl-propyl)-5-pyridin-3-yl-1,5-dihydro-pyrrol-2-one chemical structure, C24H24N4O3, CAS 609332-60-7
4-(2,5-Dimethyl-benzoyl)-3-hydroxy-1-(3-imidazol-1-yl-propyl)-5-pyridin-3-yl-1,5-dihydro-pyrrol-2-one
CAS 609332-60-7C24H24N4O3
(4E)-4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C24H24N4O4
(4E)-4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
C24H24N4O4