Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

Ring system with 4 rings and 28 atoms

13 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 28
Chemicals: 13
With full pages: 2

Scaffold SMILES

O=C1C(=O)N(CCCn2ccnc2)C(c2ccncc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C(=O)N(CCCn2ccnc2)C(c2ccncc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

4-[(2,5-Dimethylphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione chemical structure, C24H24N4O3

4-[(2,5-Dimethylphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione

C₂₄H₂₄N₄O₃

4-(3-Ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H24N4O4, CAS 609317-21-7

4-(3-Ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 609317-21-7C₂₄H₂₄N₄O₄

4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H21FN4O3

4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₃H₂₁FN₄O₃

4-(3-Chloro-4-ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H23ClN4O4

4-(3-Chloro-4-ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

C₂₄H₂₃ClN₄O₄

1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H22N4O3, CAS 378210-65-2

1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 378210-65-2C₂₃H₂₂N₄O₃

4-(4-Chlorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H19ClN4O3, CAS 378761-03-6

4-(4-Chlorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 378761-03-6C₂₂H₁₉ClN₄O₃

4-(4-Fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H19FN4O3, CAS 380592-69-8

4-(4-Fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 380592-69-8C₂₂H₁₉FN₄O₃

(4E)-4-{Hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)pyrrolidine-2,3-dione chemical structure, C25H26N4O4, CAS 384375-94-4

(4E)-4-{Hydroxy[4-(propan-2-yloxy)phenyl]methylidene}-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)pyrrolidine-2,3-dione

CAS 384375-94-4C₂₅H₂₆N₄O₄

(4E)-4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione chemical structure, C24H24N4O4

(4E)-4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione

C₂₄H₂₄N₄O₄

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H24N4O3, CAS 609332-58-3

4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(pyridin-4-yl)-2,5-dihydro-1H-pyrrol-2-one

CAS 609332-58-3C₂₄H₂₄N₄O₃

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-1-(3-(1H-imidazol-1-yl)propyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H21FN4O4, CAS 618075-09-5

4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-1-(3-(1H-imidazol-1-yl)propyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one

CAS 618075-09-5C₂₃H₂₁FN₄O₄

(4E)-4-[(3-Fluoro-4-methylphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione chemical structure, C23H21FN4O3, CAS 879195-85-4

(4E)-4-[(3-Fluoro-4-methylphenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione

CAS 879195-85-4C₂₃H₂₁FN₄O₃

1-(3-(1H-Imidazol-1-yl)propyl)-4-(3-chloro-4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H23ClN4O4, CAS 853753-26-1

1-(3-(1H-Imidazol-1-yl)propyl)-4-(3-chloro-4-ethoxybenzoyl)-3-hydroxy-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one

CAS 853753-26-1C₂₄H₂₃ClN₄O₄