Murcko scaffold
Ring system with 4 rings and 28 atoms
133 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 133
- With full pages
- 15
Scaffold SMILES
O=C1C(=O)N(CCCn2ccnc2)C(c2ccccc2)C1=Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 133 chemicals
1-(3-(1H-Imidazol-1-yl)propyl)-4-benzoyl-5-(4-chlorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
C23H20ClN3O3
![4-[(4-Ethoxyphenyl)hydroxymethylene]-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(2-propen-1-yloxy)phenyl]-2,3-pyrrolidinedione chemical structure, C28H29N3O5, CAS 1104244-17-8](/s/UBNOHTNURPJPRQ-UHFFFAOYSA-N.svg)
4-[(4-Ethoxyphenyl)hydroxymethylene]-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(2-propen-1-yloxy)phenyl]-2,3-pyrrolidinedione
CAS 1104244-17-8C28H29N3O5
![4-[Hydroxy(phenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-phenylpyrrolidine-2,3-dione chemical structure, C23H21N3O3](/s/USXDVGXLSJKKBV-UHFFFAOYSA-N.svg)
4-[Hydroxy(phenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-phenylpyrrolidine-2,3-dione
C23H21N3O3
![4-[Hydroxy-(4-methoxyphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(4-methoxyphenyl)pyrrolidine-2,3-dione chemical structure, C25H25N3O5](/s/MSHWJKYIGYCOEE-UHFFFAOYSA-N.svg)
4-[Hydroxy-(4-methoxyphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(4-methoxyphenyl)pyrrolidine-2,3-dione
C25H25N3O5
![4-[Hydroxy-(4-methoxyphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(4-propan-2-ylphenyl)pyrrolidine-2,3-dione chemical structure, C27H29N3O4](/s/BOPPOMUFCAKOEJ-UHFFFAOYSA-N.svg)
4-[Hydroxy-(4-methoxyphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(4-propan-2-ylphenyl)pyrrolidine-2,3-dione
C27H29N3O4
![4-[(4-Bromophenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-phenylpyrrolidine-2,3-dione chemical structure, C23H20BrN3O3](/s/ARVZGCWTQPNWLS-UHFFFAOYSA-N.svg)
4-[(4-Bromophenyl)-hydroxymethylidene]-1-(3-imidazol-1-ylpropyl)-5-phenylpyrrolidine-2,3-dione
C23H20BrN3O3
![5-(2,5-Dimethoxyphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24FN3O5](/s/ATHMHWHCEUSLMS-UHFFFAOYSA-N.svg)
5-(2,5-Dimethoxyphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
C25H24FN3O5
![4-(4-Fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-methoxy-4-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H28FN3O5](/s/NIRFZILRJHQHKX-UHFFFAOYSA-N.svg)
4-(4-Fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(3-methoxy-4-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C27H28FN3O5
![4-(3-Chloro-4-ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H26ClN3O4](/s/XZBDBZHRPCMKAI-UHFFFAOYSA-N.svg)
4-(3-Chloro-4-ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one
C26H26ClN3O4
![5-(4-tert-Butylphenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)pyrrolidine-2,3-dione chemical structure, C28H31N3O4](/s/INWQAKNQWNUENH-UHFFFAOYSA-N.svg)
5-(4-tert-Butylphenyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)pyrrolidine-2,3-dione
C28H31N3O4
![5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H27N3O5](/s/LPIAMWJQEFXAIX-UHFFFAOYSA-N.svg)
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C26H27N3O5
![4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H22FN3O4](/s/YGYWJZYGRFZRRA-UHFFFAOYSA-N.svg)
4-(3-Fluoro-4-methylbenzoyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
C24H22FN3O4
![5-(4-Chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H22ClN3O4](/s/NBNYYMRBGMTPGD-UHFFFAOYSA-N.svg)
5-(4-Chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C24H22ClN3O4
![4-(3-Chloro-4-ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H26ClN3O5](/s/XYRIGSZKJJNAAG-UHFFFAOYSA-N.svg)
4-(3-Chloro-4-ethoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(2-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C26H26ClN3O5
![5-(3-Chlorophenyl)-4-(2,5-dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24ClN3O3](/s/UNZPVTCTODLVAC-UHFFFAOYSA-N.svg)
5-(3-Chlorophenyl)-4-(2,5-dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
C25H24ClN3O3
![4-Benzoyl-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H27N3O3](/s/QQEIPOQGYBWRJJ-UHFFFAOYSA-N.svg)
4-Benzoyl-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
C26H27N3O3
![4-(4-Fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H26FN3O4](/s/FRBBABAALYNJDP-UHFFFAOYSA-N.svg)
4-(4-Fluorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-[4-(propan-2-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one
C26H26FN3O4
![5-(3-Bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H22BrN3O3](/s/GMHPKQGUFZFABX-UHFFFAOYSA-N.svg)
5-(3-Bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one
C24H22BrN3O3
![5-(3-Chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H24ClN3O4](/s/VFNHVTUZGUHSHM-UHFFFAOYSA-N.svg)
5-(3-Chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H24ClN3O4
![4-(3-Chloro-4-methoxybenzoyl)-5-(4-chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H21Cl2N3O4](/s/UEKHLSYICLUMBV-UHFFFAOYSA-N.svg)
4-(3-Chloro-4-methoxybenzoyl)-5-(4-chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one
C24H21Cl2N3O4
![3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(3-methoxybenzoyl)-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H29N3O4](/s/IVSQCNDTPMWTQE-UHFFFAOYSA-N.svg)
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(3-methoxybenzoyl)-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
C27H29N3O4
![3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(3-methoxybenzoyl)-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25N3O5](/s/FBVWHDNWDWUEBX-UHFFFAOYSA-N.svg)
3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(3-methoxybenzoyl)-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C25H25N3O5
![5-(3-Fluorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H24FN3O4](/s/NTCIPKQXGKDDIF-UHFFFAOYSA-N.svg)
5-(3-Fluorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H24FN3O4
![4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-phenyl-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25N3O3](/s/VQKULEMYVXJTHF-UHFFFAOYSA-N.svg)
4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-phenyl-2,5-dihydro-1H-pyrrol-2-one
C25H25N3O3
- 5-(2-Fluorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-oneC24H22FN3O4
- 3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methoxybenzoyl)-5-[4-(propan-2-yloxy)phenyl]-2,5-dihydro-1H-pyrrol-2-oneC27H29N3O5
- 5-(4-Chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-oneC26H24ClN3O4
- 4-(3-Chloro-4-ethoxybenzoyl)-5-(4-ethylphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-oneC27H28ClN3O4
- 5-(4-Chlorophenyl)-4-(2,5-dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-oneC25H24ClN3O3
- 4-(2,5-Dimethylbenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-oneC26H27N3O3
- 5-(4-Ethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-oneC26H27N3O4
- 4-[Hydroxy-(3-methoxyphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(3-nitrophenyl)pyrrolidine-2,3-dione4831-91-8C24H22N4O6
- 4-[Hydroxy(phenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-(4-prop-2-enoxyphenyl)pyrrolidine-2,3-dione4855-12-3C26H25N3O4
- 1-(3-(1H-Imidazol-1-yl)propyl)-3-hydroxy-4-(4-methylbenzoyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one337493-18-2C24H22N4O5
- 5-(4-Fluorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-2,5-dihydro-1H-pyrrol-2-one350700-12-8C24H22FN3O3
- (4Z)-4-[Hydroxy-(4-methylphenyl)methylidene]-1-(3-imidazol-1-ylpropyl)-5-phenylpyrrolidine-2,3-dione5955-27-1C24H23N3O3
- 1-(3-(1H-Imidazol-1-yl)propyl)-4-(4-chlorobenzoyl)-3-hydroxy-5-(p-tolyl)-1H-pyrrol-2(5H)-one381199-49-1C24H22ClN3O3
- 1-(3-(1H-Imidazol-1-yl)propyl)-4-(4-chlorobenzoyl)-3-hydroxy-5-(4-methoxyphenyl)-1H-pyrrol-2(5H)-one378222-54-9C24H22ClN3O4
- 4-(4-Chlorobenzoyl)-5-(4-chlorophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one381703-55-5C23H19Cl2N3O3
- 4-(4-Chlorobenzoyl)-5-(2,5-dimethoxyphenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one425395-25-1C25H24ClN3O5
- 1-(3-(1H-Imidazol-1-yl)propyl)-4-(4-chlorobenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1H-pyrrol-2(5H)-one380590-11-4C23H19ClFN3O3
- 1-(3-(1H-Imidazol-1-yl)propyl)-4-(4-chlorobenzoyl)-5-(2,4-dimethoxyphenyl)-3-hydroxy-1H-pyrrol-2(5H)-one381202-05-7C25H24ClN3O5
- 4-(4-Chlorobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-phenyl-2,5-dihydro-1H-pyrrol-2-one381171-54-6C23H20ClN3O3
- 3-Hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(4-methylbenzoyl)-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one380548-10-7C25H25N3O3
- 5-(3-Bromophenyl)-4-[(4-fluorophenyl)carbonyl]-3-hydroxy-1-(3-imidazolylpropyl)-3-pyrrolin-2-one381180-44-5C23H19BrFN3O3
- 4-(4-Bromobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methylphenyl)-2,5-dihydro-1H-pyrrol-2-one378771-69-8C24H22BrN3O3
- 4-(4-Bromobenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one380904-57-4C24H22BrN3O4
- 4-Benzoyl-5-(3-bromophenyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-2,5-dihydro-1H-pyrrol-2-one381700-06-7C23H20BrN3O3
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc(Cc2cc(=O)[nH]c(=O)[nH]2)n1-c1ccccc1)N1CCCC1](/scaffold/AGJPVMBKOQXJQY-UHFFFAOYSA-N/structure.svg)
