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Murcko scaffold

Ring system with 4 rings and 22 atoms

27 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 27
With full pages: 5

Scaffold SMILES

S=c1sc(C=C2N=c3ccccc3=N2)cn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold S=c1sc(C=C2N=c3ccccc3=N2)cn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-fluorophenyl)-2-sulfanylidene-4-thiazolidinone chemical structure, C17H10FN3OS2, CAS 304861-03-8

5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-fluorophenyl)-2-sulfanylidene-4-thiazolidinone

CAS 304861-03-8C₁₇H₁₀FN₃OS₂

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one chemical structure, C18H10F3N3OS2, CAS 301308-47-4

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-4-one

CAS 301308-47-4C₁₈H₁₀F₃N₃OS₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one chemical structure, C18H13N3OS2, CAS 854002-66-7

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-2-thioxo-3-(o-tolyl)thiazolidin-4-one

CAS 854002-66-7C₁₈H₁₃N₃OS₂

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(2-bromophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H10BrN3OS2, CAS 881562-70-5

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(2-bromophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 881562-70-5C₁₇H₁₀BrN₃OS₂

4-[(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C18H11N3O3S2, CAS 854002-68-9

4-[(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzoic acid

CAS 854002-68-9C₁₈H₁₁N₃O₃S₂

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H10ClN3OS2, CAS 881562-42-1

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 881562-42-1C₁₇H₁₀ClN₃OS₂

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3,4-dichlorophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H9Cl2N3OS2, CAS 881562-56-7

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3,4-dichlorophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 881562-56-7C₁₇H₉Cl₂N₃OS₂

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-bromophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H10BrN3OS2, CAS 881562-84-1

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-bromophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 881562-84-1C₁₇H₁₀BrN₃OS₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(3-hydroxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C17H11N3O2S2, CAS 881561-93-9

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(3-hydroxyphenyl)-2-thioxothiazolidin-4-one

CAS 881561-93-9C₁₇H₁₁N₃O₂S₂

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H11N3OS2, CAS 1164565-82-5

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one

CAS 1164565-82-5C₁₇H₁₁N₃OS₂

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3-bromophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H10BrN3OS2, CAS 881562-77-2

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3-bromophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 881562-77-2C₁₇H₁₀BrN₃OS₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2-methoxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C18H13N3O2S2, CAS 881562-07-8

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2-methoxyphenyl)-2-thioxothiazolidin-4-one

CAS 881562-07-8C₁₈H₁₃N₃O₂S₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2-ethoxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C19H15N3O2S2, CAS 881562-21-6

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2-ethoxyphenyl)-2-thioxothiazolidin-4-one

CAS 881562-21-6C₁₉H₁₅N₃O₂S₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2-fluorophenyl)-2-thioxothiazolidin-4-one chemical structure, C17H10FN3OS2, CAS 854002-70-3

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2-fluorophenyl)-2-thioxothiazolidin-4-one

CAS 854002-70-3C₁₇H₁₀FN₃OS₂

3-[(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid chemical structure, C18H11N3O3S2, CAS 881562-35-2

3-[(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]benzoic acid

CAS 881562-35-2C₁₈H₁₁N₃O₃S₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(4-ethoxyphenyl)-2-thioxothiazolidin-4-one chemical structure, C19H15N3O2S2, CAS 881562-28-3

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(4-ethoxyphenyl)-2-thioxothiazolidin-4-one

CAS 881562-28-3C₁₉H₁₅N₃O₂S₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2,3-dimethylphenyl)-2-thioxothiazolidin-4-one chemical structure, C19H15N3OS2, CAS 461714-20-5

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(2,3-dimethylphenyl)-2-thioxothiazolidin-4-one

CAS 461714-20-5C₁₉H₁₅N₃OS₂

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(2-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H10ClN3OS2, CAS 854002-72-5

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(2-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 854002-72-5C₁₇H₁₀ClN₃OS₂

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H13N3O2S2, CAS 625816-98-0

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 625816-98-0C₁₈H₁₃N₃O₂S₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(3,4-dimethylphenyl)-2-thioxothiazolidin-4-one chemical structure, C19H15N3OS2, CAS 854002-67-8

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-3-(3,4-dimethylphenyl)-2-thioxothiazolidin-4-one

CAS 854002-67-8C₁₉H₁₅N₃OS₂

(5E)-5-(1H-Benzimidazol-2-ylmethylene)-3-[4-(diethylamino)phenyl]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H20N4OS2, CAS 1164453-13-7

(5E)-5-(1H-Benzimidazol-2-ylmethylene)-3-[4-(diethylamino)phenyl]-2-thioxo-1,3-thiazolidin-4-one

CAS 1164453-13-7C₂₁H₂₀N₄OS₂

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H10ClN3OS2, CAS 881562-49-8

(5E)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(4-chlorophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 881562-49-8C₁₇H₁₀ClN₃OS₂

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-2-thioxo-3-(m-tolyl)thiazolidin-4-one chemical structure, C18H13N3OS2, CAS 881561-79-1

(Z)-5-((1H-Benzo[d]imidazol-2-yl)methylene)-2-thioxo-3-(m-tolyl)thiazolidin-4-one

CAS 881561-79-1C₁₈H₁₃N₃OS₂

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3-chloro-4-fluorophenyl)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C17H9ClFN3OS2, CAS 881562-63-6

(5Z)-5-(1H-Benzimidazol-2-ylmethylidene)-3-(3-chloro-4-fluorophenyl)-2-thioxo-1,3-thiazolidin-4-one

CAS 881562-63-6C₁₇H₉ClFN₃OS₂