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Murcko scaffold

Ring system with 4 rings and 24 atoms

32 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
32
With full pages
3
Scaffold SMILES

c1ccc(Nc2ncnc3ccc(OC4CCNCC4)cc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Nc2ncnc3ccc(OC4CCNCC4)cc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(2-methoxyethyl)piperidin-4-yl]oxy}quinazoline chemical structure, C23H26ClFN4O3, CAS 612500-83-1
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-{[1-(2-methoxyethyl)piperidin-4-yl]oxy}quinazoline
CAS 612500-83-1C23H26ClFN4O3
4-(3-Chloro-2-fluoroanilino)-6-{[1-(methylsulfonyl)piperidin-4-yl]oxy}-7-methoxyquinazoline chemical structure, C21H22ClFN4O4S, CAS 612500-85-3
4-(3-Chloro-2-fluoroanilino)-6-{[1-(methylsulfonyl)piperidin-4-yl]oxy}-7-methoxyquinazoline
CAS 612500-85-3C21H22ClFN4O4S
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[(1-methylpiperidin-4-yl)oxy]quinazoline chemical structure, C21H22ClFN4O2, CAS 612500-80-8
4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[(1-methylpiperidin-4-yl)oxy]quinazoline
CAS 612500-80-8C21H22ClFN4O2
4-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidine-1-carbonitrile chemical structure, C21H19ClFN5O2, CAS 609767-58-0
4-[4-(3-Chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidine-1-carbonitrile
CAS 609767-58-0C21H19ClFN5O2
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[[1-(methylsulfonyl)-4-piperidinyl]oxy]-4-quinazolinamine chemical structure, C21H22ClFN4O4S, CAS 609767-51-3
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[[1-(methylsulfonyl)-4-piperidinyl]oxy]-4-quinazolinamine
CAS 609767-51-3C21H22ClFN4O4S
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(1-methylpiperidin-4-yl)oxyquinazolin-4-amine chemical structure, C21H22ClFN4O2, CAS 609767-45-5
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(1-methylpiperidin-4-yl)oxyquinazolin-4-amine
CAS 609767-45-5C21H22ClFN4O2
4-[(3-Chloro-4-fluoro-phenyl)amino]-6-(piperidin-4-yloxy)-7-methoxy-quinazoline chemical structure, C20H20ClFN4O2, CAS 609767-48-8
4-[(3-Chloro-4-fluoro-phenyl)amino]-6-(piperidin-4-yloxy)-7-methoxy-quinazoline
CAS 609767-48-8C20H20ClFN4O2
N-(3-Chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine chemical structure, C20H20ClFN4O2, CAS 612500-78-4
N-(3-Chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine
CAS 612500-78-4C20H20ClFN4O2
6-{[1-(Carbamoylmethyl)piperidin-4-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline chemical structure, C22H23ClFN5O3, CAS 612500-87-5
6-{[1-(Carbamoylmethyl)piperidin-4-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline
CAS 612500-87-5C22H23ClFN5O3
N-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)-6-[(1-methyl-4-piperidinyl)oxy]-4-quinazolinamine chemical structure, C23H26ClFN4O3, CAS 610303-39-4
N-(3-Chloro-4-fluorophenyl)-7-(2-methoxyethoxy)-6-[(1-methyl-4-piperidinyl)oxy]-4-quinazolinamine
CAS 610303-39-4C23H26ClFN4O3
N-(3-Chloro-4-fluorophenyl)-7-ethoxy-6-[[1-(methylsulfonyl)-4-piperidinyl]oxy]-4-quinazolinamine chemical structure, C22H24ClFN4O4S, CAS 610302-76-6
N-(3-Chloro-4-fluorophenyl)-7-ethoxy-6-[[1-(methylsulfonyl)-4-piperidinyl]oxy]-4-quinazolinamine
CAS 610302-76-6C22H24ClFN4O4S
tert-Butyl 4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidine-1-carboxylate chemical structure, C25H28ClFN4O4, CAS 609767-43-3
tert-Butyl 4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidine-1-carboxylate
CAS 609767-43-3C25H28ClFN4O4
4-(3-Chloro-2-fluoroanilino)-6-[1-(hydroxyacetyl)piperidin-4-yloxy]-7-methoxyquinazoline chemical structure, C22H22ClFN4O4, CAS 842121-97-5
4-(3-Chloro-2-fluoroanilino)-6-[1-(hydroxyacetyl)piperidin-4-yloxy]-7-methoxyquinazoline
CAS 842121-97-5C22H22ClFN4O4
N-(3-Ethynylphenyl)-7-methoxy-6-[[1-(methylsulfonyl)-4-piperidinyl]oxy]-4-quinazolinamine chemical structure, C23H24N4O4S, CAS 610302-93-7
N-(3-Ethynylphenyl)-7-methoxy-6-[[1-(methylsulfonyl)-4-piperidinyl]oxy]-4-quinazolinamine
CAS 610302-93-7C23H24N4O4S
N-(3-Ethynylphenyl)-7-methoxy-6-(1-methylpiperidin-4-yl)oxyquinazolin-4-amine chemical structure, C23H24N4O2, CAS 774180-32-4
N-(3-Ethynylphenyl)-7-methoxy-6-(1-methylpiperidin-4-yl)oxyquinazolin-4-amine
CAS 774180-32-4C23H24N4O2
1-[4-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-methoxyethanone chemical structure, C25H26N4O4, CAS 610302-92-6
1-[4-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-methoxyethanone
CAS 610302-92-6C25H26N4O4
tert-Butyl 4-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxypiperidine-1-carboxylate chemical structure, C27H30N4O4, CAS 610303-42-9
tert-Butyl 4-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxypiperidine-1-carboxylate
CAS 610303-42-9C27H30N4O4
1-[4-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]ethanone chemical structure, C24H24N4O3, CAS 610302-91-5
1-[4-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]ethanone
CAS 610302-91-5C24H24N4O3
4-[[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidineacetamide chemical structure, C22H23ClFN5O3, CAS 850795-59-4
4-[[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidineacetamide
CAS 850795-59-4C22H23ClFN5O3
Sapitinib chemical structure, C23H25ClFN5O3, CAS 848942-61-0
Sapitinib
CAS 848942-61-0C23H25ClFN5O3
Poziotinib chemical structure, C23H21Cl2FN4O3, CAS 1092364-38-9
Poziotinib
CAS 1092364-38-9C23H21Cl2FN4O3
1-(4-{[4-(3-Ethynylanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)prop-2-en-1-one chemical structure, C25H24N4O3, CAS 1092364-39-0
1-(4-{[4-(3-Ethynylanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)prop-2-en-1-one
CAS 1092364-39-0C25H24N4O3
Sapitinib difumurate chemical structure, C31H33ClFN5O11, CAS 1196531-39-1
Sapitinib difumurate
CAS 1196531-39-1C31H33ClFN5O11
Poziotinib hydrochloride chemical structure, C23H22Cl3FN4O3, CAS 1429757-68-5
Poziotinib hydrochloride
CAS 1429757-68-5C23H22Cl3FN4O3