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Murcko scaffold

Ring system with 3 rings and 21 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
12
With full pages
4
Scaffold SMILES

O=C(Nc1ccccc1)C1=CNC(=S)NC1c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1=CNC(=S)NC1c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

6-Methyl-N-phenyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C16H15N3OS2, CAS 313230-09-0
6-Methyl-N-phenyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 313230-09-0C16H15N3OS2
N-(4-Bromophenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C16H14BrN3OS2, CAS 331272-57-2
N-(4-Bromophenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 331272-57-2C16H14BrN3OS2
6-Methyl-N-(2-methylphenyl)-4-(2-thienyl)-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C17H17N3OS2, CAS 312735-07-2
6-Methyl-N-(2-methylphenyl)-4-(2-thienyl)-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 312735-07-2C17H17N3OS2
N-(4-Chlorophenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C16H14ClN3OS2, CAS 5769-16-4
N-(4-Chlorophenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 5769-16-4C16H14ClN3OS2
N-(3-Chlorophenyl)-6-methyl-4-(thiophen-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C16H14ClN3OS2, CAS 438479-88-0
N-(3-Chlorophenyl)-6-methyl-4-(thiophen-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 438479-88-0C16H14ClN3OS2
N-(2-Chlorophenyl)-6-methyl-4-(thiophen-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C16H14ClN3OS2, CAS 438485-61-1
N-(2-Chlorophenyl)-6-methyl-4-(thiophen-2-yl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 438485-61-1C16H14ClN3OS2
N-(2-Methoxyphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C17H17N3O2S2, CAS 313702-30-6
N-(2-Methoxyphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 313702-30-6C17H17N3O2S2
N-(2,4-Dimethoxyphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H19N3O3S2, CAS 380434-39-9
N-(2,4-Dimethoxyphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 380434-39-9C18H19N3O3S2
N-(3,4-Difluorophenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C16H13F2N3OS2, CAS 440091-26-9
N-(3,4-Difluorophenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 440091-26-9C16H13F2N3OS2
N-(2,4-Dimethylphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H19N3OS2, CAS 379252-56-9
N-(2,4-Dimethylphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 379252-56-9C18H19N3OS2
N-(2,5-Dimethylphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H19N3OS2, CAS 537680-50-5
N-(2,5-Dimethylphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 537680-50-5C18H19N3OS2
N-(2,3-Dimethylphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H19N3OS2, CAS 374090-84-3
N-(2,3-Dimethylphenyl)-6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 374090-84-3C18H19N3OS2