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Murcko scaffold

Ring system with 2 rings and 13 atoms

10 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
10
With full pages
5
Scaffold SMILES

O=c1ccnc(-n2[nH]ccc2=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccnc(-n2[nH]ccc2=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

Ethyl 2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate chemical structure, C13H16N4O5, CAS 210417-17-7
Ethyl 2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate
CAS 210417-17-7C13H16N4O5
Ethyl 2-(3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate chemical structure, C11H12N4O4, CAS 866133-57-5
Ethyl 2-(3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylate
CAS 866133-57-5C11H12N4O4
Ethyl 6-oxo-2-[5-oxo-3-(trifluoromethyl)-2,5-dihydro-1H-pyrazol-1-yl]-1,6-dihydro-5-pyrimidinecarboxylate chemical structure, C11H9F3N4O4, CAS 866145-60-0
Ethyl 6-oxo-2-[5-oxo-3-(trifluoromethyl)-2,5-dihydro-1H-pyrazol-1-yl]-1,6-dihydro-5-pyrimidinecarboxylate
CAS 866145-60-0C11H9F3N4O4
6-Hydroxy-2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-5-octyl-4(3H)-pyrimidinone chemical structure, C18H28N4O4, CAS 866145-44-0
6-Hydroxy-2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-5-octyl-4(3H)-pyrimidinone
CAS 866145-44-0C18H28N4O4
5-Hexyl-2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-methyl-4(3H)-pyrimidinone chemical structure, C17H26N4O3, CAS 866138-06-9
5-Hexyl-2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-methyl-4(3H)-pyrimidinone
CAS 866138-06-9C17H26N4O3
2-[4-(2-Hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-methyl-4(3H)-pyrimidinone chemical structure, C11H14N4O3, CAS 210417-20-2
2-[4-(2-Hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-methyl-4(3H)-pyrimidinone
CAS 210417-20-2C11H14N4O3
Ethyl 3-{2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-4-methyl-6-oxo-1,6-dihydro-5-pyrimidinyl}propanoate chemical structure, C16H22N4O5, CAS 860611-64-9
Ethyl 3-{2-[4-(2-hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-4-methyl-6-oxo-1,6-dihydro-5-pyrimidinyl}propanoate
CAS 860611-64-9C16H22N4O5
6-Methyl-2-(3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-4(3H)-pyrimidinone chemical structure, C9H10N4O2, CAS 53068-50-1
6-Methyl-2-(3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)-4(3H)-pyrimidinone
CAS 53068-50-1C9H10N4O2
2-[4-(2-Hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-(trifluoromethyl)-4(3H)-pyrimidinone chemical structure, C11H11F3N4O3, CAS 866138-03-6
2-[4-(2-Hydroxyethyl)-3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl]-6-(trifluoromethyl)-4(3H)-pyrimidinone
CAS 866138-03-6C11H11F3N4O3
2-(2,5-Dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)-5,6-dimethyl-4(3H)-pyrimidinone chemical structure, C10H12N4O2, CAS 97209-10-4
2-(2,5-Dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)-5,6-dimethyl-4(3H)-pyrimidinone
CAS 97209-10-4C10H12N4O2