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Murcko scaffold

2-(1,3-Dioxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide scaffold

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
10
With full pages
5
Scaffold SMILES

O=C(CN1C(=O)c2ccccc2C1=O)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(1,3-Dioxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide page
Murcko scaffold O=C(CN1C(=O)c2ccccc2C1=O)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

N-(5-Acetyl-4-methylthiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide chemical structure, C16H13N3O4S, CAS 392290-20-9
N-(5-Acetyl-4-methylthiazol-2-yl)-2-(1,3-dioxoisoindolin-2-yl)acetamide
CAS 392290-20-9C16H13N3O4S
Ethyl (2-{[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]amino}-1,3-thiazol-4-yl)acetate chemical structure, C17H15N3O5S, CAS 301226-79-9
Ethyl (2-{[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]amino}-1,3-thiazol-4-yl)acetate
CAS 301226-79-9C17H15N3O5S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C14H11N3O3S, CAS 832120-35-1
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(5-methyl-1,3-thiazol-2-yl)acetamide
CAS 832120-35-1C14H11N3O3S
2-(1,3-Dioxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide chemical structure, C13H9N3O3S, CAS 65919-36-0
2-(1,3-Dioxoisoindolin-2-yl)-N-(thiazol-2-yl)acetamide
CAS 65919-36-0C13H9N3O3S
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-N-thiazol-2-yl-butyramide chemical structure, C16H15N3O3S, CAS 305377-28-0
2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-N-thiazol-2-yl-butyramide
CAS 305377-28-0C16H15N3O3S
Ethyl 2-(2-(1,3-dioxoisoindolin-2-yl)-4-methylpentanamido)-4-methylthiazole-5-carboxylate chemical structure, C21H23N3O5S, CAS 292161-47-8
Ethyl 2-(2-(1,3-dioxoisoindolin-2-yl)-4-methylpentanamido)-4-methylthiazole-5-carboxylate
CAS 292161-47-8C21H23N3O5S
2-(1,3-Dioxoisoindolin-2-yl)-4-methyl-N-(thiazol-2-yl)pentanamide chemical structure, C17H17N3O3S, CAS 294647-30-6
2-(1,3-Dioxoisoindolin-2-yl)-4-methyl-N-(thiazol-2-yl)pentanamide
CAS 294647-30-6C17H17N3O3S
2-(1,3-Dioxoisoindol-2-yl)-N-(5-nitro-1,3-thiazol-2-yl)acetamide chemical structure, C13H8N4O5S, CAS 126281-12-7
2-(1,3-Dioxoisoindol-2-yl)-N-(5-nitro-1,3-thiazol-2-yl)acetamide
CAS 126281-12-7C13H8N4O5S
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)propanamide chemical structure, C14H11N3O3S, CAS 301196-19-0
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)propanamide
CAS 301196-19-0C14H11N3O3S
Ethyl 2-[2-(1,3-dioxoisoindol-2-yl)acetyl]imino-3,4-dimethyl-1,3-thiazole-5-carboxylate chemical structure, C18H17N3O5S, CAS 393838-96-5
Ethyl 2-[2-(1,3-dioxoisoindol-2-yl)acetyl]imino-3,4-dimethyl-1,3-thiazole-5-carboxylate
CAS 393838-96-5C18H17N3O5S