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Murcko scaffold

Ring system with 3 rings and 28 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
28
Chemicals
14
With full pages
13
Scaffold SMILES

O=C(NCCCn1ccnc1)C(=Cc1ccccc1)NC(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCCn1ccnc1)C(=Cc1ccccc1)NC(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

N-[(Z)-3-(3-Imidazol-1-ylpropylamino)-3-oxo-1-phenylprop-1-en-2-yl]benzamide chemical structure, C22H22N4O2, CAS 324542-94-1
N-[(Z)-3-(3-Imidazol-1-ylpropylamino)-3-oxo-1-phenylprop-1-en-2-yl]benzamide
CAS 324542-94-1C22H22N4O2
N-[2-(4-Chlorophenyl)-1-({[3-(1H-imidazol-1-yl)propyl]amino}carbonyl)vinyl]-4-methylbenzamide chemical structure, C23H23ClN4O2, CAS 312936-17-7
N-[2-(4-Chlorophenyl)-1-({[3-(1H-imidazol-1-yl)propyl]amino}carbonyl)vinyl]-4-methylbenzamide
CAS 312936-17-7C23H23ClN4O2
N-((Z)-1-(((3-(1H-Imidazol-1-yl)propyl)amino)carbonyl)-2-(4-methoxyphenyl)ethenyl)-4-methylbenzamide chemical structure, C24H26N4O3, CAS 324564-94-5
N-((Z)-1-(((3-(1H-Imidazol-1-yl)propyl)amino)carbonyl)-2-(4-methoxyphenyl)ethenyl)-4-methylbenzamide
CAS 324564-94-5C24H26N4O3
N-[(Z)-3-(3-Imidazol-1-ylpropylamino)-1-(4-methoxyphenyl)-3-oxoprop-1-en-2-yl]-4-nitrobenzamide chemical structure, C23H23N5O5, CAS 374091-08-4
N-[(Z)-3-(3-Imidazol-1-ylpropylamino)-1-(4-methoxyphenyl)-3-oxoprop-1-en-2-yl]-4-nitrobenzamide
CAS 374091-08-4C23H23N5O5
N-[2-(4-Fluoro-phenyl)-1-(3-imidazol-1-yl-propylcarbamoyl)-vinyl]-benzamide chemical structure, C22H21FN4O2, CAS 331454-74-1
N-[2-(4-Fluoro-phenyl)-1-(3-imidazol-1-yl-propylcarbamoyl)-vinyl]-benzamide
CAS 331454-74-1C22H21FN4O2
N-[(Z)-3-(3-Imidazol-1-ylpropylamino)-3-oxo-1-(4-propan-2-ylphenyl)prop-1-en-2-yl]benzamide chemical structure, C25H28N4O2, CAS 372508-22-0
N-[(Z)-3-(3-Imidazol-1-ylpropylamino)-3-oxo-1-(4-propan-2-ylphenyl)prop-1-en-2-yl]benzamide
CAS 372508-22-0C25H28N4O2
N-[(E)-3-(3-Imidazol-1-ylpropylamino)-1-(4-methylsulfanylphenyl)-3-oxoprop-1-en-2-yl]benzamide chemical structure, C23H24N4O2S, CAS 381709-18-8
N-[(E)-3-(3-Imidazol-1-ylpropylamino)-1-(4-methylsulfanylphenyl)-3-oxoprop-1-en-2-yl]benzamide
CAS 381709-18-8C23H24N4O2S
N-[(E)-1-(4-Bromophenyl)-3-(3-imidazol-1-ylpropylamino)-3-oxoprop-1-en-2-yl]-2-fluorobenzamide chemical structure, C22H20BrFN4O2, CAS 378768-26-4
N-[(E)-1-(4-Bromophenyl)-3-(3-imidazol-1-ylpropylamino)-3-oxoprop-1-en-2-yl]-2-fluorobenzamide
CAS 378768-26-4C22H20BrFN4O2
N-[1-(3-Imidazol-1-yl-propylcarbamoyl)-2-phenyl-vinyl]-4-methoxy-benzamide chemical structure, C23H24N4O3, CAS 333345-26-9
N-[1-(3-Imidazol-1-yl-propylcarbamoyl)-2-phenyl-vinyl]-4-methoxy-benzamide
CAS 333345-26-9C23H24N4O3
N-(1-(((3-(1H-Imidazol-1-yl)PR)amino)carbonyl)-2-(4-meo-phenyl)vinyl)benzamide chemical structure, C23H24N4O3, CAS 324561-94-6
N-(1-(((3-(1H-Imidazol-1-yl)PR)amino)carbonyl)-2-(4-meo-phenyl)vinyl)benzamide
CAS 324561-94-6C23H24N4O3
N-(2-(4-Chlorophenyl)-1-(((3-(1H-imidazol-1-yl)PR)amino)carbonyl)vinyl)benzamide chemical structure, C22H21ClN4O2, CAS 324561-97-9
N-(2-(4-Chlorophenyl)-1-(((3-(1H-imidazol-1-yl)PR)amino)carbonyl)vinyl)benzamide
CAS 324561-97-9C22H21ClN4O2
N-(2-(4-F-PH)-1-(((3-(1H-Imidazol-1-yl)PR)amino)carbonyl)ethenyl)-4-ME-benzamide chemical structure, C23H23FN4O2, CAS 324562-08-5
N-(2-(4-F-PH)-1-(((3-(1H-Imidazol-1-yl)PR)amino)carbonyl)ethenyl)-4-ME-benzamide
CAS 324562-08-5C23H23FN4O2
N-(2-(4-CL-PH)-1-(((3-(1H-Imidazol-1-yl)PR)amino)carbonyl)vinyl)-4-meo-benzamide chemical structure, C23H23ClN4O3, CAS 307953-19-1
N-(2-(4-CL-PH)-1-(((3-(1H-Imidazol-1-yl)PR)amino)carbonyl)vinyl)-4-meo-benzamide
CAS 307953-19-1C23H23ClN4O3
4-Chloro-N-((Z)-2-(3,4-dimethoxyphenyl)-1-(((3-(1H-imidazol-1-yl)propyl)amino)carbonyl)ethenyl)benzamide chemical structure, C24H25ClN4O4, CAS 624726-78-9
4-Chloro-N-((Z)-2-(3,4-dimethoxyphenyl)-1-(((3-(1H-imidazol-1-yl)propyl)amino)carbonyl)ethenyl)benzamide
CAS 624726-78-9C24H25ClN4O4