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Murcko scaffold

Ring system with 2 rings and 11 atoms

36 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
36
With full pages
5
Scaffold SMILES

c1cnc(-c2nccs2)nc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1cnc(-c2nccs2)nc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

(2-(Pyrimidin-2-yl)thiazol-4-yl)methanamine chemical structure, C8H8N4S, CAS 1123169-55-0
(2-(Pyrimidin-2-yl)thiazol-4-yl)methanamine
CAS 1123169-55-0C8H8N4S
2-(Pyrimidin-2-yl)-1,3-thiazole-4-carboxylic acid chemical structure, C8H5N3O2S, CAS 1014631-26-5
2-(Pyrimidin-2-yl)-1,3-thiazole-4-carboxylic acid
CAS 1014631-26-5C8H5N3O2S
2-[4-(Chloromethyl)-1,3-thiazol-2-yl]pyrimidine chemical structure, C8H6ClN3S, CAS 1154009-17-2
2-[4-(Chloromethyl)-1,3-thiazol-2-yl]pyrimidine
CAS 1154009-17-2C8H6ClN3S
2-[2-(Pyrimidin-2-yl)-1,3-thiazol-4-yl]acetic acid chemical structure, C9H7N3O2S, CAS 1154009-60-5
2-[2-(Pyrimidin-2-yl)-1,3-thiazol-4-yl]acetic acid
CAS 1154009-60-5C9H7N3O2S
4-Methyl-2-(2-pyrimidinyl)-5-thiazolecarboxylic acid chemical structure, C9H7N3O2S, CAS 1104276-29-0
4-Methyl-2-(2-pyrimidinyl)-5-thiazolecarboxylic acid
CAS 1104276-29-0C9H7N3O2S
2-(Pyrimidin-2-yl)-1,3-thiazole-5-carboxylic acid chemical structure, C8H5N3O2S, CAS 1014630-98-8
2-(Pyrimidin-2-yl)-1,3-thiazole-5-carboxylic acid
CAS 1014630-98-8C8H5N3O2S
2-(2-(Pyrimidin-2-yl)thiazol-4-yl)ethanamine chemical structure, C9H10N4S, CAS 1209170-85-3
2-(2-(Pyrimidin-2-yl)thiazol-4-yl)ethanamine
CAS 1209170-85-3C9H10N4S
2-(Pyrimidin-2-yl)-1,3-thiazole-4-carbaldehyde chemical structure, C8H5N3OS, CAS 1178019-16-3
2-(Pyrimidin-2-yl)-1,3-thiazole-4-carbaldehyde
CAS 1178019-16-3C8H5N3OS
4-Ethyl-2-pyrimidin-2-YL-1,3-thiazole-5-carboxylic acid chemical structure, C10H9N3O2S, CAS 1104276-25-6
4-Ethyl-2-pyrimidin-2-YL-1,3-thiazole-5-carboxylic acid
CAS 1104276-25-6C10H9N3O2S
Methyl 2-pyrimidin-2-yl-1,3-thiazole-4-carboxylate chemical structure, C9H7N3O2S, CAS 1014631-25-4
Methyl 2-pyrimidin-2-yl-1,3-thiazole-4-carboxylate
CAS 1014631-25-4C9H7N3O2S
{2-[2-(2-Pyrimidinyl)-1,3-thiazol-4-yl]ethyl}amine dihydrochloride chemical structure, C9H12Cl2N4S, CAS 1426444-82-7
{2-[2-(2-Pyrimidinyl)-1,3-thiazol-4-yl]ethyl}amine dihydrochloride
CAS 1426444-82-7C9H12Cl2N4S
Methyl 2-(2-pyrimidinyl)-5-thiazolecarboxylate chemical structure, C9H7N3O2S, CAS 1014630-97-7
Methyl 2-(2-pyrimidinyl)-5-thiazolecarboxylate
CAS 1014630-97-7C9H7N3O2S
2-(Pyrimidin-2-yl)-1,3-thiazole-5-carbaldehyde chemical structure, C8H5N3OS, CAS 1235474-02-8
2-(Pyrimidin-2-yl)-1,3-thiazole-5-carbaldehyde
CAS 1235474-02-8C8H5N3OS
2-Pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid chemical structure, C9H4F3N3O2S, CAS 1104276-21-2
2-Pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid
CAS 1104276-21-2C9H4F3N3O2S
4-Methyl-2-(2-thiazolyl)-5-pyrimidinecarboxylic acid chemical structure, C9H7N3O2S, CAS 1068975-61-0
4-Methyl-2-(2-thiazolyl)-5-pyrimidinecarboxylic acid
CAS 1068975-61-0C9H7N3O2S
2-(Thiazol-2-yl)pyrimidine-5-carboxylic acid chemical structure, C8H5N3O2S, CAS 1068975-58-5
2-(Thiazol-2-yl)pyrimidine-5-carboxylic acid
CAS 1068975-58-5C8H5N3O2S
Ethyl 2-(thiazol-2-yl)pyrimidine-5-carboxylate chemical structure, C10H9N3O2S, CAS 1068975-56-3
Ethyl 2-(thiazol-2-yl)pyrimidine-5-carboxylate
CAS 1068975-56-3C10H9N3O2S
N-(1-Cyano-1-propylbutyl)-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxamide chemical structure, C16H19N5OS, CAS 1424593-65-6
N-(1-Cyano-1-propylbutyl)-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxamide
CAS 1424593-65-6C16H19N5OS
N-(1-Cyano-2,2-dimethylpropyl)-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxamide chemical structure, C14H15N5OS, CAS 1427583-18-3
N-(1-Cyano-2,2-dimethylpropyl)-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxamide
CAS 1427583-18-3C14H15N5OS
2-(5-Methylpyrimidin-2-yl)-1,3-thiazole-5-carboxylic acid chemical structure, C9H7N3O2S, CAS 1554055-56-9
2-(5-Methylpyrimidin-2-yl)-1,3-thiazole-5-carboxylic acid
CAS 1554055-56-9C9H7N3O2S
2-(4,6-Dichloropyrimidin-2-yl)thiazole chemical structure, C7H3Cl2N3S, CAS 1564983-53-4
2-(4,6-Dichloropyrimidin-2-yl)thiazole
CAS 1564983-53-4C7H3Cl2N3S
2-(4-Chloro-6-methylpyrimidin-2-yl)-1,3-thiazole chemical structure, C8H6ClN3S, CAS 1566466-91-8
2-(4-Chloro-6-methylpyrimidin-2-yl)-1,3-thiazole
CAS 1566466-91-8C8H6ClN3S
5-Amino-2-(thiazol-2-yl)pyrimidine chemical structure, C7H6N4S, CAS 1564628-23-4
5-Amino-2-(thiazol-2-yl)pyrimidine
CAS 1564628-23-4C7H6N4S
2-(5-Bromo-4-chloropyrimidin-2-yl)thiazole chemical structure, C7H3BrClN3S, CAS 1565960-27-1
2-(5-Bromo-4-chloropyrimidin-2-yl)thiazole
CAS 1565960-27-1C7H3BrClN3S