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Murcko scaffold

Ring system with 3 rings and 17 atoms

173 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
173
With full pages
20
Scaffold SMILES

O=c1c2ccccc2ccn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c2ccccc2ccn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 173 chemicals

8-Chloro-3-methyl-1-oxo-2-phenyl-1,2-dihydro-isoquinoline-4-carboxylic acid methyl ester chemical structure, C18H14ClNO3, CAS 1075715-05-7
8-Chloro-3-methyl-1-oxo-2-phenyl-1,2-dihydro-isoquinoline-4-carboxylic acid methyl ester
CAS 1075715-05-7C18H14ClNO3
8-Methyl-1-oxo-2-o-tolyl-1,2-dihydro-isoquinoline-3-carboxylic acid ethyl ester chemical structure, C20H19NO3, CAS 1172117-30-4
8-Methyl-1-oxo-2-o-tolyl-1,2-dihydro-isoquinoline-3-carboxylic acid ethyl ester
CAS 1172117-30-4C20H19NO3
3-(Bromomethyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one chemical structure, C18H16BrNO, CAS 1172117-32-6
3-(Bromomethyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one
CAS 1172117-32-6C18H16BrNO
3-(Hydroxymethyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one chemical structure, C18H17NO2, CAS 1172117-31-5
3-(Hydroxymethyl)-8-methyl-2-o-tolylisoquinolin-1(2H)-one
CAS 1172117-31-5C18H17NO2
2-(3-Bromo-phenyl)-6-dimethylamino-2H-isoquinolin-1-one chemical structure, C17H15BrN2O, CAS 1178884-36-0
2-(3-Bromo-phenyl)-6-dimethylamino-2H-isoquinolin-1-one
CAS 1178884-36-0C17H15BrN2O
2-Bromo-6-(6-tert-butyl-1-oxo-1H-isoquinolin-2-yl)-benzaldehyde chemical structure, C20H18BrNO2, CAS 1198765-02-4
2-Bromo-6-(6-tert-butyl-1-oxo-1H-isoquinolin-2-yl)-benzaldehyde
CAS 1198765-02-4C20H18BrNO2
2-(3-Bromo-2-methyl-phenyl)-6-dimethylamino-2H-isoquinolin-1-one chemical structure, C18H17BrN2O, CAS 1178884-40-6
2-(3-Bromo-2-methyl-phenyl)-6-dimethylamino-2H-isoquinolin-1-one
CAS 1178884-40-6C18H17BrN2O
N-(2-Methoxyethyl)-1-oxo-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinoline-4-carboxamide chemical structure, C22H24N2O6, CAS 1351696-25-7
N-(2-Methoxyethyl)-1-oxo-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinoline-4-carboxamide
CAS 1351696-25-7C22H24N2O6
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one chemical structure, C17H15ClN2O, CAS 1350643-72-9
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one
CAS 1350643-72-9C17H15ClN2O
3-(7-Hydroxy-1-oxo-1H-isoquinolin-2-yl)-4-methylbenzoic acid chemical structure, C17H13NO4, CAS 895569-32-1
3-(7-Hydroxy-1-oxo-1H-isoquinolin-2-yl)-4-methylbenzoic acid
CAS 895569-32-1C17H13NO4
8-Amino-3-methyl-1-oxo-2-phenyl-1,2-dihydro-isoquinoline-4-carboxylic acid methyl ester chemical structure, C18H16N2O3, CAS 1075715-17-1
8-Amino-3-methyl-1-oxo-2-phenyl-1,2-dihydro-isoquinoline-4-carboxylic acid methyl ester
CAS 1075715-17-1C18H16N2O3
Methyl 4-(6-methoxy-1-oxoisoquinolin-2(1H)-yl)benzoate chemical structure, C18H15NO4, CAS 1416018-26-2
Methyl 4-(6-methoxy-1-oxoisoquinolin-2(1H)-yl)benzoate
CAS 1416018-26-2C18H15NO4
Methyl 4-(6-methoxy-3-methyl-1-oxoisoquinolin-2(1H)-yl)benzoate chemical structure, C19H17NO4, CAS 1416018-35-3
Methyl 4-(6-methoxy-3-methyl-1-oxoisoquinolin-2(1H)-yl)benzoate
CAS 1416018-35-3C19H17NO4
3-(Aminomethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one chemical structure, C16H13ClN2O, CAS 1425045-12-0
3-(Aminomethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one
CAS 1425045-12-0C16H13ClN2O
2-(2,6-Dimethylphenyl)isoquinolin-1(2H)-one chemical structure, C17H15NO, CAS 137515-86-7
2-(2,6-Dimethylphenyl)isoquinolin-1(2H)-one
CAS 137515-86-7C17H15NO
Methyl 2-(bromomethyl)-4-(6-hydroxy-1-oxo-2(1H)-isoquinolinyl)benzoate chemical structure, C18H14BrNO4, CAS 1432661-61-4
Methyl 2-(bromomethyl)-4-(6-hydroxy-1-oxo-2(1H)-isoquinolinyl)benzoate
CAS 1432661-61-4C18H14BrNO4
1-Oxo-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinoline-4-carboxylic acid chemical structure, C19H17NO6, CAS 1352517-20-4
1-Oxo-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinoline-4-carboxylic acid
CAS 1352517-20-4C19H17NO6
Methyl N-{[2-(2,5-dimethoxyphenyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate chemical structure, C22H22N2O6, CAS 1401586-88-6
Methyl N-{[2-(2,5-dimethoxyphenyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate
CAS 1401586-88-6C22H22N2O6
Methyl N-{[2-(2-methoxyphenyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate chemical structure, C21H20N2O5, CAS 1401601-76-0
Methyl N-{[2-(2-methoxyphenyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate
CAS 1401601-76-0C21H20N2O5
N~4~-isopropyl-2-(2-methoxyphenyl)-1-oxo-1,2-dihydro-4-isoquinolinecarboxamide chemical structure, C20H20N2O3, CAS 1401597-26-9
N~4~-isopropyl-2-(2-methoxyphenyl)-1-oxo-1,2-dihydro-4-isoquinolinecarboxamide
CAS 1401597-26-9C20H20N2O3
Methyl N-{[1-oxo-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate chemical structure, C23H24N2O7, CAS 1401585-48-5
Methyl N-{[1-oxo-2-(3,4,5-trimethoxyphenyl)-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate
CAS 1401585-48-5C23H24N2O7
N-(2-Methoxyethyl)-1-oxo-2-(3,4,5-trifluorophenyl)-1,2-dihydroisoquinoline-4-carboxamide chemical structure, C19H15F3N2O3, CAS 1436005-86-5
N-(2-Methoxyethyl)-1-oxo-2-(3,4,5-trifluorophenyl)-1,2-dihydroisoquinoline-4-carboxamide
CAS 1436005-86-5C19H15F3N2O3
Methyl N-{[1-oxo-2-(3,4,5-trifluorophenyl)-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate chemical structure, C20H15F3N2O4, CAS 1435980-99-6
Methyl N-{[1-oxo-2-(3,4,5-trifluorophenyl)-1,2-dihydroisoquinolin-4-yl]carbonyl}-beta-alaninate
CAS 1435980-99-6C20H15F3N2O4
Methyl N-{[2-(4-methoxyphenyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]carbonyl}glycinate chemical structure, C20H18N2O5, CAS 1442079-58-4
Methyl N-{[2-(4-methoxyphenyl)-1-oxo-1,2-dihydroisoquinolin-4-yl]carbonyl}glycinate
CAS 1442079-58-4C20H18N2O5